1TFQ

NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP

Summary for 1TFQ

• Entry DOI: 10.2210/pdb1tfq/pdb
• Related: 1TFT
• Descriptor: Baculoviral IAP repeat-containing protein 4, ZINC ION, N-METHYLALANYL-3-METHYLVALYL-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE (3 entities in total)
• Functional Keywords: complex, ligand-protein, apoptosis, bir, xiap
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P98170
• Total number of polymer chains: 1
• Total formula weight: 13932.95

Authors

Oost, T.K.,Sun, C.,Armstrong, R.C.,Al-Assaad, A.S.,Betz, S.F.,Deckwerth, T.L.,Elmore, S.W.,Meadows, R.P.,Olejniczak, E.T.,Oleksijew, A.,Oltersdorf, T.,Rosenberg, S.H.,Shoemaker, A.R.,Zou, H.,Fesik, S.W. (deposition date: 2004-05-27, release date: 2004-09-07, Last modification date: 2022-03-02)

• Primary citation: Oost, T.K.,Sun, C.,Armstrong, R.C.,Al-Assaad, A.S.,Betz, S.F.,Deckwerth, T.L.,Ding, H.,Elmore, S.W.,Meadows, R.P.,Olejniczak, E.T.,Oleksijew, A.,Oltersdorf, T.,Rosenberg, S.H.,Shoemaker, A.R.,Tomaselli, K.J.,Zou, H.,Fesik, S.W.; Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer.; J.Med.Chem., 47:4417-4426, 2004; PubMed: 15317454; DOI: 10.1021/jm040037k

Experimental method

SOLUTION NMR