7TVA

Stat5a Core in complex with AK2292

Summary for 7TVA

Entry DOI	10.2210/pdb7tva/pdb
Descriptor	Signal transducer and activator of transcription 5A, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N-(5-{2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}pent-4-yn-1-yl)-N-methyl-N~3~-[4-(1,3-thiazol-2-yl)phenyl]-beta-alaninamide, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywords	stat5a, activator, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	134112.01
Authors	Meagher, J.L.,Stuckey, J.A. (deposition date: 2022-02-04, release date: 2023-02-15, Last modification date: 2024-04-03)
Primary citation	Kaneshige, A.,Bai, L.,Wang, M.,McEachern, D.,Meagher, J.L.,Xu, R.,Wang, Y.,Jiang, W.,Metwally, H.,Kirchhoff, P.D.,Zhao, L.,Jiang, H.,Wang, M.,Wen, B.,Sun, D.,Stuckey, J.A.,Wang, S. A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo. Nat.Chem.Biol., 19:703-711, 2023 Cited by PubMed: 36732620 DOI: 10.1038/s41589-022-01248-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.835 Å)

Structure validation