7TVA
Stat5a Core in complex with AK2292
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Signal transducer and activator of transcription 5A | polymer | 573 | 65828.7 | 2 | UniProt (P42229) Pfam (PF01017) Pfam (PF02864) Pfam (PF21354) Pfam (PF00017) | Homo sapiens (human) | |
| 2 | C, E (A, B) | N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N-(5-{2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}pent-4-yn-1-yl)-N-methyl-N~3~-[4-(1,3-thiazol-2-yl)phenyl]-beta-alaninamide | non-polymer | 1070.1 | 2 | Chemie (KOO) | |||
| 3 | D, G (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 4 | F (B) | MALONATE ION | non-polymer | 102.0 | 1 | Chemie (MLI) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
A, B: 136 - 705 (UniProt: P42229)
| PDB | External Database | Details |
|---|---|---|
| Ser 133 | - | expression tag |
| Asn 134 | - | expression tag |
| Ala 135 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 131657.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2454.5 | |
| All* | Total formula weight | 134112.0 |
