7UC6
Stat5a Core in complex with Compound 12
Summary for 7UC6
Entry DOI | 10.2210/pdb7uc6/pdb |
Descriptor | Signal transducer and activator of transcription 5A, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(4-bromophenyl)-N,N-dimethyl-beta-alaninamide (3 entities in total) |
Functional Keywords | stat5a, activator, transcription, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 66600.34 |
Authors | Meagher, J.L.,Stuckey, J.A. (deposition date: 2022-03-16, release date: 2023-02-15, Last modification date: 2024-05-22) |
Primary citation | Kaneshige, A.,Bai, L.,Wang, M.,McEachern, D.,Meagher, J.L.,Xu, R.,Kirchhoff, P.D.,Wen, B.,Sun, D.,Stuckey, J.A.,Wang, S. Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. J.Med.Chem., 66:2717-2743, 2023 Cited by PubMed: 36735833DOI: 10.1021/acs.jmedchem.2c01665 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.101 Å) |
Structure validation
Download full validation report