7UC7
Stat5a Core in complex with Compound 17
Summary for 7UC7
Entry DOI | 10.2210/pdb7uc7/pdb |
Descriptor | Signal transducer and activator of transcription 5A, GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(1-benzofuran-5-yl)-N,N-dimethyl-beta-alaninamide, ... (4 entities in total) |
Functional Keywords | stat5a, activator, transcription, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 66653.56 |
Authors | Meagher, J.L.,Stuckey, J.A. (deposition date: 2022-03-16, release date: 2023-02-15, Last modification date: 2024-04-03) |
Primary citation | Kaneshige, A.,Bai, L.,Wang, M.,McEachern, D.,Meagher, J.L.,Xu, R.,Kirchhoff, P.D.,Wen, B.,Sun, D.,Stuckey, J.A.,Wang, S. Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. J.Med.Chem., 66:2717-2743, 2023 Cited by PubMed: 36735833DOI: 10.1021/acs.jmedchem.2c01665 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.102 Å) |
Structure validation
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