7UC7

Stat5a Core in complex with Compound 17

Summary for 7UC7

Entry DOI	10.2210/pdb7uc7/pdb
Descriptor	Signal transducer and activator of transcription 5A, GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(1-benzofuran-5-yl)-N,N-dimethyl-beta-alaninamide, ... (4 entities in total)
Functional Keywords	stat5a, activator, transcription, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	66653.56
Authors	Meagher, J.L.,Stuckey, J.A. (deposition date: 2022-03-16, release date: 2023-02-15, Last modification date: 2024-04-03)
Primary citation	Kaneshige, A.,Bai, L.,Wang, M.,McEachern, D.,Meagher, J.L.,Xu, R.,Kirchhoff, P.D.,Wen, B.,Sun, D.,Stuckey, J.A.,Wang, S. Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. J.Med.Chem., 66:2717-2743, 2023 Cited by PubMed: 36735833 DOI: 10.1021/acs.jmedchem.2c01665 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.102 Å)

Structure validation