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PDB: 182 results
5EA8
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Crystal Structure of Prefusion RSV F Glycoprotein Fusion Inhibitor Resistance Mutant D489Y
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, D(-)-TARTARIC ACID, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P.
Deposit date:2015-10-15
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
5FHC
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BU of 5fhc by Molmil
Crystal Structure of Protective Human Antibodies 100 and 114 in Complex with Ebola Virus Fusion Glycoprotein (GP)
Descriptor: Antibody 100 Fab heavy chain, Antibody 100 Fab light chain, Antibody 114 Fab heavy chain, ...
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2015-12-21
Release date:2016-03-16
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (6.704 Å)
Cite:Structural and molecular basis for Ebola virus neutralization by protective human antibodies.
Science, 351, 2016
5EA4
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BU of 5ea4 by Molmil
Crystal Structure of Inhibitor JNJ-49153390 in Complex with Prefusion RSV F Glycoprotein
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 3-[[5-bromanyl-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-1-cyclopropyl-imidazo[4,5-c]pyridin-2-one, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P.
Deposit date:2015-10-15
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
5EA3
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BU of 5ea3 by Molmil
Crystal Structure of Inhibitor JNJ-2408068 in Complex with Prefusion RSV F Glycoprotein
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[2-[[1-(2-azanylethyl)piperidin-4-yl]amino]-4-methyl-benzimidazol-1-yl]methyl]-6-methyl-pyridin-3-ol, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S, Arnoult, E, Langedijk, J.P, Roymans, D.
Deposit date:2015-10-15
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
5FHA
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BU of 5fha by Molmil
Crystal Structure of Protective Ebola Virus Antibody 114
Descriptor: Antibody 114 Fab heavy chain, Antibody 114 Fab light chain
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2015-12-21
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.973 Å)
Cite:Structural and molecular basis for Ebola virus neutralization by protective human antibodies.
Science, 351, 2016
5FHB
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BU of 5fhb by Molmil
Crystal Structure of Protective Ebola Virus Antibody 100
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Antibody 100 Fab heavy chain, ...
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2015-12-21
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.973 Å)
Cite:Structural and molecular basis for Ebola virus neutralization by protective human antibodies.
Science, 351, 2016
8TCO
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BU of 8tco by Molmil
HCMV Trimer in complex with CS2it1p2_F7K Fab and CS4tt1p1_E3K Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CS2it1p2_F7K Fab heavy chain, ...
Authors:Goldsmith, J.G, McLellan, J.S.
Deposit date:2023-07-02
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:HCMV neutralization by broad antibody targeting
To Be Published
8TEA
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BU of 8tea by Molmil
HCMV Pentamer in complex with CS2pt1p2_A10L Fab and CS3pt1p4_C1L Fab
Descriptor: CS2pt1p2_A10L Fab heavy chain, CS2pt1p2_A10L Fab light chain, CS3pt1p4_C1L Fab heavy chain, ...
Authors:Goldsmith, J.G, McLellan, J.S.
Deposit date:2023-07-05
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:HCMV neutralization by broad antibody targeting
To Be Published
6UOE
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BU of 6uoe by Molmil
3-25 Fab germline-reversion variant bound to an HCMV gB-derived peptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-25 Fab heavy chain, 3-25 Fab light chain, ...
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2019-10-14
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step.
Plos Pathog., 16, 2020
6VKF
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BU of 6vkf by Molmil
CCHFV GP38 (IbAr10200)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GP38
Authors:Mishra, A.K, McLellan, J.S.
Deposit date:2020-01-20
Release date:2020-02-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.524 Å)
Cite:Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38.
J.Virol., 94, 2020
6WAQ
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BU of 6waq by Molmil
Crystal structure of the SARS-CoV-1 RBD bound by the cross-reactive single-domain antibody SARS VHH-72
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, nanobody SARS VHH-72
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2020-03-25
Release date:2020-04-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.
Cell, 181, 2020
6WAR
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BU of 6war by Molmil
Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein, nanobody MERS VHH-55
Authors:Wrapp, D, Torres, G.M, McLellan, J.S.
Deposit date:2020-03-25
Release date:2020-04-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.
Cell, 181, 2020
6VKM
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BU of 6vkm by Molmil
Crystal Structure of Stabilized GP from Makona Variant of Ebola Virus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Virion spike glycoprotein
Authors:Gilman, M.S.A, Rutten, L, Langedijk, J.P.M, McLellan, J.S.
Deposit date:2020-01-21
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers.
Cell Rep, 30, 2020
6VSB
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BU of 6vsb by Molmil
Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Wrapp, D, Wang, N, Corbett, K.S, Goldsmith, J.A, Hsieh, C, Abiona, O, Graham, B.S, McLellan, J.S.
Deposit date:2020-02-10
Release date:2020-02-26
Last modified:2021-01-27
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Science, 367, 2020
5TOJ
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BU of 5toj by Molmil
Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, Fibritin chimera, ...
Authors:Gilman, M.S.A, Kabeche, S.C, McLellan, J.S.
Deposit date:2016-10-17
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.
Nat Commun, 8, 2017
5TOK
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BU of 5tok by Molmil
Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, Fibritin chimera, ...
Authors:Gilman, M.S.A, Kabeche, S.C, McLellan, J.S.
Deposit date:2016-10-17
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.
Nat Commun, 8, 2017
5TP3
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BU of 5tp3 by Molmil
Crystal structure of the RSV-neutralizing single-domain antibody F-VHH-4
Descriptor: F-VHH-4
Authors:Wrapp, D, Gilman, M.S.A, McLellan, J.S.
Deposit date:2016-10-19
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.874 Å)
Cite:Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.
Nat Commun, 8, 2017
5VZR
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BU of 5vzr by Molmil
Crystal Structure of MERS-CoV neutralizing antibody G4 Fab
Descriptor: G4 antibody heavy chain, G4 antibody light chain, GLYCEROL
Authors:Wang, N, Wrapp, D, McLellan, J.S.
Deposit date:2017-05-29
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W23
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BU of 5w23 by Molmil
Crystal Structure of RSV F in complex with 5C4 Fab
Descriptor: 5C4 Fab heavy chain, 5C4 Fab light chain, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2017-06-05
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.
Nat Commun, 8, 2017
7SJ0
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BU of 7sj0 by Molmil
Antibody A7V3 bound to N-terminal domain of the spike
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, A7V3 Fab heavy chain, A7V3 Fab light chain, ...
Authors:Hsieh, C.-L, McLellan, J.S.
Deposit date:2021-10-15
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Antibody A7V3 bound to N-terminal domain of the spike
To Be Published
7T01
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BU of 7t01 by Molmil
SARS-CoV-2 S-RBD + Fab 54042-4
Descriptor: 54042-4 Fab - Heavy Chain, 54042-4 Fab - Light Chain, Spike protein S1
Authors:Johnson, N.V, Mclellan, J.S.
Deposit date:2021-11-29
Release date:2022-04-13
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition.
Cell Rep, 37, 2021
7T67
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BU of 7t67 by Molmil
SARS-CoV-2 S (Spike Glycoprotein) D614G with One(1) RBD Up
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Byrne, P.O, McLellan, J.S.
Deposit date:2021-12-13
Release date:2022-08-24
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3 Å)
Cite:IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern.
Nat Commun, 13, 2022
7T3M
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BU of 7t3m by Molmil
SARS-CoV-2 S (Spike Glycoprotein) D614G with Three (3) RBDs Up, Bound to Antibody 2-7 scFv, composite map
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 2-7 scFv, ...
Authors:Byrne, P.O, McLellan, J.S.
Deposit date:2021-12-08
Release date:2022-08-24
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern.
Nat Commun, 13, 2022
7UR4
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BU of 7ur4 by Molmil
Cryo-EM Structure of the Neutralizing Antibody MPV467 in Complex with Prefusion Human Metapneumovirus F Glycoprotein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, MPV467 Fab Heavy chain, ...
Authors:Rush, S.A, McLellan, J.S.
Deposit date:2022-04-21
Release date:2022-06-08
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SSC
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BU of 7ssc by Molmil
TRL345 lineage ancestor I8 Fab bound to an HCMV gB-derived peptide
Descriptor: Envelope glycoprotein B peptide, GLYCEROL, TRL345-I8 Fab heavy chain, ...
Authors:Sponholtz, M.R, McLellan, J.S.
Deposit date:2021-11-10
Release date:2022-10-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus.
Plos Pathog., 19, 2023

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