7T3M

SARS-CoV-2 S (Spike Glycoprotein) D614G with Three (3) RBDs Up, Bound to Antibody 2-7 scFv, composite map

Summary for 7T3M

• Entry DOI: 10.2210/pdb7t3m/pdb
• EMDB information: 25663
• Descriptor: Spike glycoprotein, Antibody 2-7 scFv, variable heavy chain VH, Antibody 2-7 scFv, variable light chain VL, ... (5 entities in total)
• Functional Keywords: virus, coronavirus, sars cov-2, sars-cov-2, spike, 2-7, d614g, rbd, 3 rbds up, three rbds up, scfv, complex, phage display, viral protein, local refinement, focused refinement, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 9
• Total formula weight: 468328.75

Authors

Byrne, P.O.,McLellan, J.S. (deposition date: 2021-12-08, release date: 2022-08-24, Last modification date: 2023-03-08)

• Primary citation: Chang, M.R.,Tomasovic, L.,Kuzmina, N.A.,Ronk, A.J.,Byrne, P.O.,Johnson, R.,Storm, N.,Olmedillas, E.,Hou, Y.J.,Schafer, A.,Leist, S.R.,Tse, L.V.,Ke, H.,Coherd, C.,Nguyen, K.,Kamkaew, M.,Honko, A.,Zhu, Q.,Alter, G.,Saphire, E.O.,McLellan, J.S.,Griffiths, A.,Baric, R.S.,Bukreyev, A.,Marasco, W.A.; IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern.; Nat Commun, 13:5814-5814, 2022; PubMed: 36192374; DOI: 10.1038/s41467-022-33030-4

Experimental method

ELECTRON MICROSCOPY (3 Å)