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PDB: 138 件
8ED8
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BU of 8ed8 by Molmil
cryo-EM structure of TRPM3 ion channel in the presence of PIP2 and PregS, state 1
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ...
著者Zhao, C, MacKinnon, R.
登録日2022-09-03
公開日2022-11-02
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
8ED9
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BU of 8ed9 by Molmil
cryo-EM structure of TRPM3 ion channel in the presence with PIP2 and PregS, state 2
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ...
著者Zhao, C, MacKinnon, R.
登録日2022-09-03
公開日2022-11-09
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
8GHF
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BU of 8ghf by Molmil
cryo-EM structure of hSlo1 in plasma membrane vesicles
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ...
著者Tao, X, Zhao, C, MacKinnon, R.
登録日2023-03-10
公開日2023-05-10
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Membrane protein isolation and structure determination in cell-derived membrane vesicles.
Proc.Natl.Acad.Sci.USA, 120, 2023
4KFM
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BU of 4kfm by Molmil
Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits
分子名称: DODECYL-BETA-D-MALTOSIDE, G protein-activated inward rectifier potassium channel 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Whorton, M.R, MacKinnon, R.
登録日2013-04-27
公開日2013-06-12
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献X-ray structure of the mammalian GIRK2-beta gamma G-protein complex.
Nature, 498, 2013
7S5Y
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BU of 7s5y by Molmil
Human KATP channel in open conformation, focused on Kir and one SUR, position 2
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
著者Zhao, C, MacKinnon, R.
登録日2021-09-12
公開日2021-12-01
最終更新日2021-12-08
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7S5Z
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BU of 7s5z by Molmil
Human KATP channel in open conformation, focused on Kir and one SUR, position 3
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
著者Zhao, C, MacKinnon, R.
登録日2021-09-12
公開日2021-12-01
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
4I9W
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BU of 4i9w by Molmil
Human two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure
分子名称: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Brohawn, S.G, Mackinnon, R.
登録日2012-12-05
公開日2013-01-23
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel.
Proc.Natl.Acad.Sci.USA, 110, 2013
1OTS
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BU of 1ots by Molmil
Structure of the Escherichia coli ClC Chloride channel and Fab Complex
分子名称: CHLORIDE ION, Fab fragment (heavy chain), Fab fragment (light chain), ...
著者Dutzler, R, Campbell, E.B, MacKinnon, R.
登録日2003-03-22
公開日2003-04-15
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
1OTU
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BU of 1otu by Molmil
Structure of the Escherichia coli ClC Chloride channel E148Q mutant and Fab Complex
分子名称: CHLORIDE ION, Fab fragment (Heavy chain), Fab fragment (Light chain), ...
著者Dutzler, R, Campbell, E.B, MacKinnon, R.
登録日2003-03-23
公開日2003-04-15
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
8ED7
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BU of 8ed7 by Molmil
cryo-EM structure of TRPM3 ion channel in apo state
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, Transient receptor potential cation channel, subfamily M, ...
著者Zhao, C, MacKinnon, R.
登録日2022-09-03
公開日2022-11-02
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
8EMX
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BU of 8emx by Molmil
Phospholipase C beta 3 (PLCb3) in complex with Gbg on lipid nanodiscs
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Falzone, M.E, MacKinnon, R.
登録日2022-09-28
公開日2023-05-24
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EMV
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BU of 8emv by Molmil
Phospholipase C beta 3 (PLCb3) in solution
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION
著者Falzone, M.E, MacKinnon, R.
登録日2022-09-28
公開日2023-05-24
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EMW
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BU of 8emw by Molmil
Phospholipase C beta 3 (PLCb3) in complex with Gbg on liposomes
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Falzone, M.E, MacKinnon, R.
登録日2022-09-28
公開日2023-05-24
最終更新日2024-09-25
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DDU
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BU of 8ddu by Molmil
cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state3
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ...
著者Zhao, C, MacKinnon, R.
登録日2022-06-19
公開日2022-11-02
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
8DDS
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BU of 8dds by Molmil
cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state1
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ...
著者Zhao, C, MacKinnon, R.
登録日2022-06-18
公開日2022-11-02
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
8DDQ
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BU of 8ddq by Molmil
cryo-EM structure of TRPM3 ion channel in the presence of soluble Gbg, focused on channel
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ...
著者Zhao, C, MacKinnon, R.
登録日2022-06-18
公開日2022-11-02
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
8DDT
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BU of 8ddt by Molmil
cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state2
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ...
著者Zhao, C, MacKinnon, R.
登録日2022-06-18
公開日2022-11-02
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
8DDR
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BU of 8ddr by Molmil
cryo-EM structure of TRPM3 ion channel in the absence of PIP2
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ...
著者Zhao, C, MacKinnon, R.
登録日2022-06-18
公開日2022-11-02
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
8DDX
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BU of 8ddx by Molmil
cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhao, C, MacKinnon, R.
登録日2022-06-19
公開日2022-11-02
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
8DDV
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BU of 8ddv by Molmil
Cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state4
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ...
著者Zhao, C, MacKinnon, R.
登録日2022-06-19
公開日2022-11-02
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron, 111, 2023
6PBY
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BU of 6pby by Molmil
Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 1)
分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily H member 1
著者Whicher, J.R, MacKinnon, R.
登録日2019-06-14
公開日2019-09-18
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.67 Å)
主引用文献Regulation of Eag1 gating by its intracellular domains.
Elife, 8, 2019
6PBX
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BU of 6pbx by Molmil
Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 2)
分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily H member 1
著者Whicher, J.R, MacKinnon, R.
登録日2019-06-14
公開日2019-09-18
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Regulation of Eag1 gating by its intracellular domains.
Elife, 8, 2019
8GHG
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BU of 8ghg by Molmil
Cryo-EM structure of hSlo1 in digitonin, Ca2+-free and EDTA-free
分子名称: Calcium-activated potassium channel subunit alpha-1
著者Tao, X, Zhao, C, MacKinnon, R.
登録日2023-03-10
公開日2023-05-10
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Membrane protein isolation and structure determination in cell-derived membrane vesicles.
Proc.Natl.Acad.Sci.USA, 120, 2023
8GH9
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BU of 8gh9 by Molmil
Cryo-EM structure of hSlo1 in total membrane vesicles
分子名称: Calcium-activated potassium channel subunit alpha-1
著者Tao, X, Zhao, C, MacKinnon, R.
登録日2023-03-09
公開日2023-05-10
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Membrane protein isolation and structure determination in cell-derived membrane vesicles.
Proc.Natl.Acad.Sci.USA, 120, 2023
1ORQ
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BU of 1orq by Molmil
X-ray structure of a voltage-dependent potassium channel in complex with an Fab
分子名称: 6E1 Fab heavy chain, 6E1 Fab light chain, CADMIUM ION, ...
著者Jiang, Y, Lee, A, Chen, J, Ruta, V, Cadene, M, Chait, B.T, MacKinnon, R.
登録日2003-03-14
公開日2003-05-06
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003

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件を2024-11-06に公開中

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