2POD
| Crystal structure of a member of enolase superfamily from Burkholderia pseudomallei K96243 | Descriptor: | Mandelate racemase / muconate lactonizing enzyme, SODIUM ION | Authors: | Patskovsky, Y, Bonanno, J, Sauder, J.M, Gilmore, J.M, Iizuka, M, Ozyurt, S, Wasserman, S.R, Smith, D, Gerlt, J, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-04-26 | Release date: | 2007-06-05 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Crystal Structure of a Member of Enolase Superfamily from Burkholderia Pseudomallei. To be Published
|
|
3BJU
| Crystal Structure of tetrameric form of human lysyl-tRNA synthetase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, LYSINE, ... | Authors: | Guo, M, Yang, X.L, Schimmel, P. | Deposit date: | 2007-12-04 | Release date: | 2008-02-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
5CCG
| Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) | Descriptor: | CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | Authors: | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T. | Deposit date: | 2015-07-02 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. Nature, 525, 2015
|
|
3B47
| Periplasmic sensor domain of chemotaxis protein GSU0582 | Descriptor: | Methyl-accepting chemotaxis protein, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Pokkuluri, P.R, Schiffer, M. | Deposit date: | 2007-10-23 | Release date: | 2008-04-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures and solution properties of two novel periplasmic sensor domains with c-type heme from chemotaxis proteins of Geobacter sulfurreducens: implications for signal transduction. J.Mol.Biol., 377, 2008
|
|
3K8Q
| Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H | Descriptor: | 7-({[2-hydroxy-1-(hydroxymethyl)ethyl]amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase | Authors: | Ho, M, Almo, S.C, Scharmm, V.L. | Deposit date: | 2009-10-14 | Release date: | 2010-03-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human nucleoside phosphorylase in complex with SerMe-ImmH Proc.Natl.Acad.Sci.USA, 2010
|
|
8QDZ
| |
8QE1
| Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 15 | Descriptor: | 4-[4-[bis(fluoranyl)methoxy]phenyl]-3-cyclopropyl-6-(4-methoxyphenyl)-2~{H}-pyrazolo[4,3-b]pyridin-5-one, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 | Authors: | Schimpl, M. | Deposit date: | 2023-08-30 | Release date: | 2024-03-20 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.095 Å) | Cite: | Development of a Series of Pyrrolopyridone MAT2A Inhibitors. J.Med.Chem., 67, 2024
|
|
5CFH
| |
8QE3
| Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 31 | Descriptor: | 3-cyclopropyl-6-(2-methylindazol-5-yl)-4-(6-methylpyridin-3-yl)-2~{H}-pyrazolo[4,3-b]pyridin-5-one, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 | Authors: | Schimpl, M. | Deposit date: | 2023-08-30 | Release date: | 2024-03-20 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.089 Å) | Cite: | Development of a Series of Pyrrolopyridone MAT2A Inhibitors. J.Med.Chem., 67, 2024
|
|
3KA7
| Crystal Structure of an oxidoreductase from Methanosarcina mazei. Northeast Structural Genomics Consortium target id MaR208 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Oxidoreductase | Authors: | Seetharaman, J, Su, M, Wang, D, Janjua, H, Cunningham, K, Owens, L, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-10-18 | Release date: | 2009-11-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of an oxidoreductase from Methanosarcina mazei To be Published
|
|
1UNC
| Solution structure of the human villin C-terminal headpiece subdomain | Descriptor: | VILLIN 1 | Authors: | Vermeulen, W, Van Troys, M, Vanhaesebrouck, P, Verschueren, M, Fant, F, Ampe, C, Martins, J, Borremans, F. | Deposit date: | 2003-09-09 | Release date: | 2004-07-15 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | Solution Structures of the C-Terminal Headpiece Subdomains of Human Villin and Advillin, Evaluation of Headpiece F-Actin-Binding Requirements Protein Sci., 13, 2004
|
|
1UJP
| Crystal Structure of Tryptophan Synthase A-Subunit From Thermus thermophilus HB8 | Descriptor: | CITRIC ACID, Tryptophan synthase alpha chain | Authors: | Asada, Y, Yokoyama, S, Kuramitsu, S, Miyano, M, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-08-08 | Release date: | 2003-08-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Stabilization mechanism of the tryptophan synthase alpha-subunit from Thermus thermophilus HB8: X-ray crystallographic analysis and calorimetry. J.Biochem.(Tokyo), 138, 2005
|
|
3J67
| Structural mechanism of the dynein powerstroke (post-powerstroke state) | Descriptor: | Dynein motor domain | Authors: | Lin, J, Okada, K, Raytchev, M, Smith, M.C, Nicastro, D. | Deposit date: | 2013-12-22 | Release date: | 2014-04-23 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (34 Å) | Cite: | Structural mechanism of the dynein power stroke. Nat.Cell Biol., 16, 2014
|
|
8QDY
| |
3J70
| Model of gp120, including variable regions, in complex with CD4 and 17b | Descriptor: | Envelope glycoprotein gp120, T-cell surface glycoprotein CD4, envelope glycoprotein gp41, ... | Authors: | Rasheed, M, Bettadapura, R, Bajaj, C. | Deposit date: | 2014-04-22 | Release date: | 2015-08-26 | Method: | ELECTRON MICROSCOPY (20 Å) | Cite: | Computational Refinement and Validation Protocol for Proteins with Large Variable Regions Applied to Model HIV Env Spike in CD4 and 17b Bound State. Structure, 23, 2015
|
|
3J79
| Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Wong, W, Bai, X.C, Brown, A, Fernandez, I.S, Hanssen, E, Condron, M, Tan, Y.H, Baum, J, Scheres, S.H.W. | Deposit date: | 2014-06-02 | Release date: | 2014-07-16 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine. Elife, 3, 2014
|
|
3J94
| Structure of ATP-bound N-ethylmaleimide sensitive factor determined by single particle cryoelectron microscopy | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Vesicle-fusing ATPase | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | Deposit date: | 2014-12-05 | Release date: | 2015-01-28 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Mechanistic insights into the recycling machine of the SNARE complex. Nature, 518, 2015
|
|
3K62
| Crystal structure of FBF-2/gld-1 FBEb complex | Descriptor: | 5'-R(*UP*GP*UP*GP*UP*UP*AP*UP*C)-3', Fem-3 mRNA-binding factor 2 | Authors: | Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T. | Deposit date: | 2009-10-08 | Release date: | 2009-11-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein. Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
6ZUG
| Crystal Structure of Thrombin in complex with compound10 | Descriptor: | 2-[(3-chlorophenyl)methylamino]-7-methoxy-~{N}-[[(3~{S})-oxolan-3-yl]methyl]-~{N}-propyl-1,3-benzoxazole-5-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hirudin-2, ... | Authors: | Schafer, M. | Deposit date: | 2020-07-22 | Release date: | 2020-08-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics. J.Med.Chem., 63, 2020
|
|
6ZUU
| Crystal structure of Thrombin in complex with compound30 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hirudin-2, Prothrombin, ... | Authors: | Schafer, M. | Deposit date: | 2020-07-23 | Release date: | 2020-10-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics. J.Med.Chem., 63, 2020
|
|
6ZV7
| Crystal Structure of Thrombin in complex with compound42b | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hirudin-2, Prothrombin, ... | Authors: | Schafer, M. | Deposit date: | 2020-07-24 | Release date: | 2020-08-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics. J.Med.Chem., 63, 2020
|
|
4DGM
| Crystal Structure of maize CK2 in complex with the inhibitor apigenin | Descriptor: | 1,2-ETHANEDIOL, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Casein kinase II subunit alpha, ... | Authors: | Lolli, G, Mazzorana, M, Battistutta, R. | Deposit date: | 2012-01-26 | Release date: | 2012-08-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. Biochemistry, 51, 2012
|
|
3JBF
| Complex of poliovirus with VHH PVSP19B | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | Authors: | Strauss, M, Schotte, L, Thys, B, Filman, D.J, Hogle, J.M. | Deposit date: | 2015-08-26 | Release date: | 2016-01-27 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site. J.Virol., 90, 2016
|
|
7QX3
| Structure of the transaminase TR2E2 with EOS | Descriptor: | 2-azanylethyl hydrogen sulfate, Aminotransferase TR2 | Authors: | Roda, S, Fernandez-Lopez, L, Benedens, M, Bollinger, A, Thies, S, Schumacher, J, Coscolin, C, Kazemi, M, Santiago, G, Gertzen, C.G, Gonzalez-Alfonso, J, Plou, F.J, Jaeger, K.E, Smits, S.H, Ferrer, M, Guallar, V. | Deposit date: | 2022-01-26 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | A Plurizyme with Transaminase and Hydrolase Activity Catalyzes Cascade Reactions. Angew.Chem.Int.Ed.Engl., 61, 2022
|
|
7QX0
| Transaminase Structure of Plurienzyme (Tr2E2) in complex with PLP | Descriptor: | Aminotransferase TR2, PYRIDOXAL-5'-PHOSPHATE | Authors: | Roda, S, Fernandez-Lopez, L, Benedens, M, Bollinger, A, Thies, S, Schumacher, J, Coscolin, C, Kazemi, M, Santiago, G, Gertzen, C.G, Gonzalez-Alfonso, J, Plou, F.J, Jaeger, K.E, Smits, S.H, Ferrer, M, Guallar, V. | Deposit date: | 2022-01-26 | Release date: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | A Plurizyme with Transaminase and Hydrolase Activity Catalyzes Cascade Reactions. Angew Chem Int Ed Engl, 61, 2022
|
|