4N7D
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![BU of 4n7d by Molmil](/molmil-images/mine/4n7d) | Selenomethionine incorporated Bla g 4 | Descriptor: | Bla g 4 allergen variant 1, CITRIC ACID, GLYCEROL | Authors: | Offermann, L.R, Chan, S.L, Osinski, T, Tan, Y.W, Chew, F.T, Sivaraman, J, Mok, Y.K, Minor, W, Chruszcz, M. | Deposit date: | 2013-10-15 | Release date: | 2014-05-21 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The major cockroach allergen Bla g 4 binds tyramine and octopamine. Mol.Immunol., 60, 2014
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6JY6
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![BU of 6jy6 by Molmil](/molmil-images/mine/6jy6) | Structure of dark-state marine bacterial chloride importer, NM-R3, with Pulse laser (ND-1%) at 95K. | Descriptor: | CHLORIDE ION, Chloride pumping rhodopsin, OLEIC ACID, ... | Authors: | Yun, J.H, Ohki, M, Park, S.Y, Lee, W. | Deposit date: | 2019-04-26 | Release date: | 2020-03-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Pumping mechanism of NM-R3, a light-driven bacterial chloride importer in the rhodopsin family. Sci Adv, 6, 2020
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4N7J
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6FT1
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![BU of 6ft1 by Molmil](/molmil-images/mine/6ft1) | Crystal structure of oxidised Flavodoxin 1 from Bacillus cereus (1.4 A resolution) | Descriptor: | FLAVIN MONONUCLEOTIDE, Flavodoxin, SULFATE ION, ... | Authors: | Gudim, I, Lofstad, M, Hersleth, H.-P. | Deposit date: | 2018-02-20 | Release date: | 2018-07-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | High-resolution crystal structures reveal a mixture of conformers of the Gly61-Asp62 peptide bond in an oxidized flavodoxin from Bacillus cereus. Protein Sci., 27, 2018
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6JYC
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![BU of 6jyc by Molmil](/molmil-images/mine/6jyc) | Structure of dark-state marine bacterial chloride importer, NM-R3, with CW laser (ND-30%) at 95K. | Descriptor: | CHLORIDE ION, Chloride pumping rhodopsin, OLEIC ACID, ... | Authors: | Yun, J.H, Ohki, M, Park, S.Y, Lee, W. | Deposit date: | 2019-04-26 | Release date: | 2020-03-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | Pumping mechanism of NM-R3, a light-driven bacterial chloride importer in the rhodopsin family. Sci Adv, 6, 2020
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5B0H
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![BU of 5b0h by Molmil](/molmil-images/mine/5b0h) | CRYSTAL STRUCTURE OF HUMAN LEUKOCYTE CELL-DERIVED CHEMOTAXIN 2 | Descriptor: | Leukocyte cell-derived chemotaxin-2, SULFATE ION, ZINC ION | Authors: | Zheng, H, Miyakawa, T, Sawano, Y, Tanokura, M. | Deposit date: | 2015-10-29 | Release date: | 2016-07-06 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold J.Biol.Chem., 291, 2016
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4N9D
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![BU of 4n9d by Molmil](/molmil-images/mine/4n9d) | Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1,2-ETHANEDIOL, 4-({[(4-tert-butylphenyl)sulfonyl]amino}methyl)-N-(pyridin-3-yl)benzamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X. | Deposit date: | 2013-10-20 | Release date: | 2014-02-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24, 2014
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3MY6
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![BU of 3my6 by Molmil](/molmil-images/mine/3my6) | Crystal Structure of the complex of type 1 ribosome inactivating protein with 7-methylguanine at 2.65 A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one, Ribosome-inactivating protein momordin I | Authors: | Kushwaha, G.S, Singh, N, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2010-05-10 | Release date: | 2010-08-04 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal Structure of the complex of type 1 ribosome inactivating protein with 7-methylguanine at 2.65 A resolution To be Published
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4N9W
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![BU of 4n9w by Molmil](/molmil-images/mine/4n9w) | Crystal structure of phosphatidyl mannosyltransferase PimA | Descriptor: | 1,2-ETHANEDIOL, GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase, GUANOSINE-5'-DIPHOSPHATE | Authors: | Giganti, D, Albesa-Jove, D, Bellinzoni, M, Guerin, M.E, Alzari, P.M. | Deposit date: | 2013-10-21 | Release date: | 2014-11-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Secondary structure reshuffling modulates glycosyltransferase function at the membrane. Nat.Chem.Biol., 11, 2015
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8AFV
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![BU of 8afv by Molmil](/molmil-images/mine/8afv) | DaArgC3 - Engineered Formyl Phosphate Reductase with 3 substitutions (S178V, G182V, L233I) | Descriptor: | N-acetyl-gamma-glutamyl-phosphate reductase, SODIUM ION | Authors: | Pfister, P, Nattermann, M, Zarzycki, J, Erb, T.J. | Deposit date: | 2022-07-18 | Release date: | 2023-04-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | N-acetyl-gamma-glutamyl-phosphate reductase of Denitrovibrio acetiphilus To Be Published
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8AE7
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![BU of 8ae7 by Molmil](/molmil-images/mine/8ae7) | The strucuture of Compound 15 bound to CK2alpha | Descriptor: | 2-[5,6-bis(bromanyl)-1H-indazol-3-yl]ethanenitrile, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Brear, P, De Fusco, C, Atkinson, E, Frances, N, Iegre, J, Venkitaraman, A, Hyvonen, M, Spring, D. | Deposit date: | 2022-07-12 | Release date: | 2023-03-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | A fragment-based approach leading to the discovery of inhibitors of CK2 alpha with a novel mechanism of action. Rsc Med Chem, 13, 2022
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1LNT
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![BU of 1lnt by Molmil](/molmil-images/mine/1lnt) | Crystal Structure of the Highly Conserved RNA Internal Loop of SRP | Descriptor: | 5'-R(*CP*GP*GP*AP*AP*GP*CP*AP*GP*(CBV)P*GP*C)-3', 5'-R(*GP*CP*GP*UP*CP*AP*GP*GP*UP*CP*(CBV)P*G)-3', CALCIUM ION, ... | Authors: | Deng, J, Xiong, Y, Pan, B, Sundaralingam, M. | Deposit date: | 2002-05-03 | Release date: | 2003-06-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of an RNA dodecamer containing a fragment from SRP domain IV of Escherichia coli. Acta Crystallogr.,Sect.D, 59, 2003
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5B2M
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![BU of 5b2m by Molmil](/molmil-images/mine/5b2m) | A crucial role of Cys218 in the stabilization of an unprecedented auto-inhibition form of MAP2K7 | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 7 | Authors: | Sogabe, Y, Hashimoto, T, Matsumoto, T, Kirii, Y, Sawa, M, Kinoshita, T. | Deposit date: | 2016-01-19 | Release date: | 2016-04-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7 Biochem.Biophys.Res.Commun., 473, 2016
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4MPK
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![BU of 4mpk by Molmil](/molmil-images/mine/4mpk) | Crystal structure of the complex of buffalo signaling protein SPB-40 with N-acetylglucosamine at 2.65 A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase-3-like protein 1, GLYCEROL | Authors: | Yamini, S, Chaudhary, A, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2013-09-13 | Release date: | 2013-11-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal structure of the complex of buffalo signaling protein SPB-40 with N-acetylglucosamine at 2.65 A resolution To be Published
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3OJM
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4MQM
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![BU of 4mqm by Molmil](/molmil-images/mine/4mqm) | Crystal structure of Antigen 85C in presence of Ebselen | Descriptor: | Diacylglycerol acyltransferase/mycolyltransferase Ag85C | Authors: | Favrot, L, Grzegorzewicz, A.E, Lajiness, D.H, Marvin, R.K, Boucau, J, Isailovic, D, Jackson, M, Ronning, D.R. | Deposit date: | 2013-09-16 | Release date: | 2013-11-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.346 Å) | Cite: | Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen. Nat Commun, 4, 2013
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6K0N
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![BU of 6k0n by Molmil](/molmil-images/mine/6k0n) | Catalytic domain of GH87 alpha-1,3-glucanase in complex with nigerose | Descriptor: | ACETIC ACID, Alpha-1,3-glucanase, CALCIUM ION, ... | Authors: | Itoh, T, Intuy, R, Suyotha, W, Hayashi, J, Yano, S, Makabe, K, Wakayama, M, Hibi, T. | Deposit date: | 2019-05-07 | Release date: | 2019-12-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural insights into substrate recognition and catalysis by glycoside hydrolase family 87 alpha-1,3-glucanase from Paenibacillus glycanilyticus FH11. Febs J., 287, 2020
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8AXV
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![BU of 8axv by Molmil](/molmil-images/mine/8axv) | Structure of an open form of CHIKV nsP1 capping pores | Descriptor: | 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one, ZINC ION, mRNA-capping enzyme nsP1 | Authors: | Reguera, J, Jones, R, Hons, M. | Deposit date: | 2022-09-01 | Release date: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores. Proc.Natl.Acad.Sci.USA, 120, 2023
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4MPS
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![BU of 4mps by Molmil](/molmil-images/mine/4mps) | Crystal structure of rat Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1), Northeast Structural Genomics Consortium Target RnR367A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-galactoside alpha-2,6-sialyltransferase 1 | Authors: | Forouhar, F, Meng, L, Milaninia, S, Seetharaman, J, Su, M, Kornhaber, G, Montelione, G.T, Hunt, J.F, Moremen, K.W, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-09-13 | Release date: | 2013-09-25 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Enzymatic Basis for N-Glycan Sialylation: STRUCTURE OF RAT alpha 2,6-SIALYLTRANSFERASE (ST6GAL1) REVEALS CONSERVED AND UNIQUE FEATURES FOR GLYCAN SIALYLATION. J.Biol.Chem., 288, 2013
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6K0P
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![BU of 6k0p by Molmil](/molmil-images/mine/6k0p) | Catalytic domain of GH87 alpha-1,3-glucanase D1045A in complex with nigerose | Descriptor: | ACETIC ACID, Alpha-1,3-glucanase, CALCIUM ION, ... | Authors: | Itoh, T, Intuy, R, Suyotha, W, Hayashi, J, Yano, S, Makabe, K, Wakayama, M, Hibi, T. | Deposit date: | 2019-05-07 | Release date: | 2019-12-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.424 Å) | Cite: | Structural insights into substrate recognition and catalysis by glycoside hydrolase family 87 alpha-1,3-glucanase from Paenibacillus glycanilyticus FH11. Febs J., 287, 2020
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8AX4
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5B4V
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![BU of 5b4v by Molmil](/molmil-images/mine/5b4v) | Crystal structure of D-3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate | Descriptor: | 3-hydroxybutyrate dehydrogenase, CHLORIDE ION, METHYLMALONIC ACID, ... | Authors: | Kanazawa, H, Tsunoda, M, Hoque, M.M, Suzuki, K, Yamamoto, T, Takenaka, A. | Deposit date: | 2016-04-19 | Release date: | 2016-08-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural insights into the catalytic reaction trigger and inhibition of D-3-hydroxybutyrate dehydrogenase Acta Crystallogr.,Sect.F, 72, 2016
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6G6S
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![BU of 6g6s by Molmil](/molmil-images/mine/6g6s) | Crystal structure of human Acinus RNA recognition motif domain | Descriptor: | Apoptotic chromatin condensation inducer in the nucleus | Authors: | Fernandes, H, Czapinska, H, Grudziaz, K, Bujnicki, J.M, Nowacka, M. | Deposit date: | 2018-04-03 | Release date: | 2018-06-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure of human Acinus RNA recognition motif domain. PeerJ, 6, 2018
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8B07
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5B56
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![BU of 5b56 by Molmil](/molmil-images/mine/5b56) | Crystal structure of HIV-1 VPR C-Terminal domain and DIBB-M-Importin-Alpha2 complex | Descriptor: | Importin subunit alpha-1, Protein Vpr | Authors: | Miyatake, H, Sanjoh, A, Matusda, G, Murakami, T, Murakami, H, Hagiwara, K, Yokoyama, M, Sato, H, Miyamoto, Y, Dohmae, N, Aida, Y. | Deposit date: | 2016-04-25 | Release date: | 2016-06-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular Mechanism of HIV-1 Vpr for Binding to Importin-alpha J.Mol.Biol., 428, 2016
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