5B4V

Crystal structure of D-3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate

Summary for 5B4V

• Entry DOI: 10.2210/pdb5b4v/pdb
• Related: 5B4T 5B4U
• Descriptor: 3-hydroxybutyrate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, METHYLMALONIC ACID, ... (6 entities in total)
• Functional Keywords: short-chain dehydrogenases/reductases, inhibitor, complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Alcaligenes faecalis
• Total number of polymer chains: 1
• Total formula weight: 28004.88

Authors

Kanazawa, H.,Tsunoda, M.,Hoque, M.M.,Suzuki, K.,Yamamoto, T.,Takenaka, A. (deposition date: 2016-04-19, release date: 2016-08-17, Last modification date: 2024-03-20)

• Primary citation: Kanazawa, H.,Hoque, M.M.,Tsunoda, M.,Suzuki, K.,Yamamoto, T.,Kawai, G.,Kondo, J.,Takenaka, A.; Structural insights into the catalytic reaction trigger and inhibition of D-3-hydroxybutyrate dehydrogenase; Acta Crystallogr.,Sect.F, 72:507-515, 2016; PubMed: 27380367; DOI: 10.1107/S2053230X16007767

Experimental method

X-RAY DIFFRACTION (1.5 Å)