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PDB: 51630 件

7KF1
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Crystal structure of bH1 Fab variant (CDR H3 loop design 14_0130) in complex with VEGF
分子名称: CHLORIDE ION, Isoform L-VEGF206 of Vascular endothelial growth factor A, anti-VEGF-A Fab bH1 heavy chain, ...
著者Shi, R, Picard, M.-E, Manenda, M.S.
登録日2020-10-13
公開日2021-11-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal structure of bH1 Fab CDR H3 loop variants in apo form and in complex with VEGF
to be published
5YTE
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Large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with with natural dT:dATP base pair
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*AP*TP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ...
著者Zeng, H, Mondal, M, Song, R.Y, Zhang, J, Xia, B, Gao, Y.Q, Yi, C.Q.
登録日2017-11-17
公開日2018-11-21
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.
Angew. Chem. Int. Ed. Engl., 58, 2019
6V4T
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BU of 6v4t by Molmil
MPER-TMD of HIV-1 Env bound with the entry inhibitor S2C3
分子名称: 4,4'-(decane-1,10-diyl)bis(9-amino-2,3-dihydro-1H-cyclopenta[b]quinolin-4-ium), Envelope glycoprotein gp160
著者Xiao, T, Frey, G, Fu, Q, Lavine, C.L, Scott, D.A, Seaman, M.S, Chou, J.J, Chen, B.
登録日2019-11-30
公開日2020-04-01
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes.
Nat.Chem.Biol., 16, 2020
8SV3
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7-Deazapurines and 5-Halogenpyrimidine DNA duplex
分子名称: GLYCEROL, MAGNESIUM ION, Modified DNA, ...
著者Pallan, P.S, Egli, M.
登録日2023-05-15
公開日2023-10-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.
Biochemistry, 62, 2023
8SV4
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7-Deazapurines and 5-Halogenpyrimidine DNA duplex
分子名称: 1,2-ETHANEDIOL, 2-[2-(2-ethoxyethoxy)ethoxy]ethanol, ACETATE ION, ...
著者Pallan, P.S, Egli, M.
登録日2023-05-15
公開日2023-10-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.
Biochemistry, 62, 2023
6VED
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BU of 6ved by Molmil
Solution structure of the TTD and linker region of UHRF1
分子名称: E3 ubiquitin-protein ligase UHRF1
著者Lemak, A, Houliston, S, Duan, S, Ong, M.S, Arrowsmith, C.H.
登録日2019-12-31
公開日2020-06-17
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1.
Nucleic Acids Res., 48, 2020
8SSC
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BU of 8ssc by Molmil
Full-Length Methionine synthase from Thermus thermophilus HB8
分子名称: Methionine synthase, POTASSIUM ION, SULFATE ION
著者Yamada, K, Mendoza, J, Koutmos, M.
登録日2023-05-08
公開日2023-10-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo.
Nat Commun, 14, 2023
5GWX
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BU of 5gwx by Molmil
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylmethionine and sarcosine
分子名称: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, S-ADENOSYLMETHIONINE, ...
著者Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
登録日2016-09-14
公開日2016-11-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.205 Å)
主引用文献Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.
Sci Rep, 6, 2016
8SSD
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Methionine synthase, C-terminal fragment, Cobalamin and Reactivation Domains from Thermus thermophilus HB8
分子名称: Methionine synthase
著者Yamada, K, Mendoza, J, Koutmos, M.
登録日2023-05-08
公開日2023-10-11
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo.
Nat Commun, 14, 2023
8SSE
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Methionine synthase, C-terminal fragment, Cobalamin and Reactivation Domains from Thermus thermophilus HB8
分子名称: COBALAMIN, Methionine synthase
著者Yamada, K, Mendoza, J, Koutmos, M.
登録日2023-05-08
公開日2023-10-11
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo.
Nat Commun, 14, 2023
5YPO
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BU of 5ypo by Molmil
Crystal structure of PSD-95 GK domain in complex with phospho-SAPAP peptide
分子名称: Disks large homolog 4, GLYCEROL, SAPAP
著者Zhu, J, Zhou, Q, Shang, Y, Weng, Z, Zhang, R, Zhang, M.
登録日2017-11-02
公開日2018-03-14
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.
Cell Rep, 21, 2017
3B7G
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BU of 3b7g by Molmil
Human DEAD-box RNA helicase DDX20, Conserved domain I (DEAD) in complex with AMPPNP (Adenosine-(Beta,gamma)-imidotriphosphate)
分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Probable ATP-dependent RNA helicase DDX20
著者Karlberg, T, Tresaugues, L, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Kotenyova, T, Lehtio, L, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Welin, M, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC)
登録日2007-10-30
公開日2007-11-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Comparative Structural Analysis of Human DEAD-Box RNA Helicases.
Plos One, 5, 2010
5Y6T
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BU of 5y6t by Molmil
Crystal structure of endo-1,4-beta-mannanase from Eisenia fetida
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ISOPROPYL ALCOHOL, endo-1,4-beta-mannanase
著者Hirano, Y, Ueda, M, Tamada, T.
登録日2017-08-15
公開日2018-06-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Gene cloning, expression, and X-ray crystallographic analysis of a beta-mannanase from Eisenia fetida.
Enzyme.Microb.Technol., 117, 2018
5YE4
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BU of 5ye4 by Molmil
Crystal structure of the complex of di-acetylated histone H4 and 1A9D7 Fab fragment
分子名称: 1A9D7 L chain, 1A9D7 VH CH1 chain, ZINC ION, ...
著者Matsuda, T, Ito, T, Wakamori, M, Umehara, T.
登録日2017-09-15
公開日2018-08-22
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.799 Å)
主引用文献JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states.
Epigenetics, 13, 2018
6Q7M
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BU of 6q7m by Molmil
Spiral structure of E. coli RavA in the RavA-LdcI cage-like complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase RavA, Inducible lysine decarboxylase, ...
著者Arragain, B, Felix, J, Malet, H, Gutsche, I, Jessop, M.
登録日2018-12-13
公開日2020-02-12
最終更新日2020-02-19
実験手法ELECTRON MICROSCOPY (7.8 Å)
主引用文献Structural insights into ATP hydrolysis by the MoxR ATPase RavA and the LdcI-RavA cage-like complex.
Commun Biol, 3, 2020
5FA1
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BU of 5fa1 by Molmil
The structure of the beta-3-deoxy-D-manno-oct-2-ulosonic acid transferase domain of WbbB
分子名称: CYTIDINE-5'-MONOPHOSPHATE, Putative N-acetyl glucosaminyl transferase
著者Mallette, E, Ovchinnikova, O.G, Whitfield, C, Kimber, M.S.
登録日2015-12-10
公開日2016-05-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Bacterial beta-Kdo glycosyltransferases represent a new glycosyltransferase family (GT99).
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
6Q2W
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BU of 6q2w by Molmil
Crystal structure of human ROR gamma LBD in complex with a quinoline sulfonamide inverse agonist
分子名称: (2~{S})-1-[2,4-bis(chloranyl)-3-[[4-imidazol-1-yl-2-(trifluoromethyl)quinolin-8-yl]oxymethyl]phenyl]sulfonyl-~{N}-methyl-pyrrolidine-2-carboxamide, Nuclear receptor ROR-gamma
著者Ciesielski, F, Amaudrut, J, Argiriadi, M.A, Barth, M, Breinlinger, E.C, Calderwood, D.J, Cusack, K.P, Kort, M.E, Montalbetti, C, Potin, D, Poupardin, O, Spitzer, L.
登録日2018-12-03
公開日2019-05-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active ROR gamma inverse agonists.
Bioorg.Med.Chem.Lett., 29, 2019
5Y97
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Crystal structure of snake gourd seed lectin in complex with lactose
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Seed lectin, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
著者Chandran, T, Vijayan, M, Sivaji, N, Surolia, A.
登録日2017-08-23
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Ligand binding and retention in snake gourd seed lectin (SGSL). A crystallographic, thermodynamic and molecular dynamics study
Glycobiology, 28, 2018
5YSD
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BU of 5ysd by Molmil
Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Lin1841 protein, MAGNESIUM ION, ...
著者Abe, K, Nakajima, M, Taguchi, H, Arakawa, T, Fushinobu, S.
登録日2017-11-14
公開日2018-05-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and thermodynamic insights into beta-1,2-glucooligosaccharide capture by a solute-binding protein inListeria innocua.
J. Biol. Chem., 293, 2018
5XXV
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GDP-microtubule complexed with KIF5C in AMPPNP state
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N.
登録日2017-07-05
公開日2018-10-10
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (6.46 Å)
主引用文献Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
8DWL
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BU of 8dwl by Molmil
Inhibitor-3:PP1 coexpressed complex
分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase PPP1R11, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, ...
著者Choy, M.S, Srivastava, G, Page, R, Peti, W.
登録日2022-08-01
公開日2023-02-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction.
Nat Commun, 14, 2023
8DWK
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Inhibitor-3:PP1 reconstituted complex
分子名称: E3 ubiquitin-protein ligase PPP1R11, MANGANESE (II) ION, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
著者Choy, M.S, Srivastava, G, Page, R, Peti, W.
登録日2022-08-01
公開日2023-02-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction.
Nat Commun, 14, 2023
5Y8Z
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Crystal Structure Analysis of the BRD4
分子名称: 1,2-ETHANEDIOL, 5-bromanyl-N-(3,6-dimethyl-1,2-benzoxazol-5-yl)-2-methoxy-benzenesulfonamide, Bromodomain-containing protein 4, ...
著者Xu, Y, Zhang, Y, Song, M, Wang, C.
登録日2017-08-22
公開日2018-06-13
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
J. Med. Chem., 61, 2018
8SH3
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BU of 8sh3 by Molmil
Pendrin in complex with iodide
分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, IODIDE ION, ...
著者Wang, L, Hoang, A, Zhou, M.
登録日2023-04-13
公開日2024-02-07
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Mechanism of anion exchange and small-molecule inhibition of pendrin.
Nat Commun, 15, 2024
6Y9C
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The structure of a quaternary ammonium Rieske monooxygenase reveals insights into carnitine oxidation by gut microbiota and inter-subunit electron transfer
分子名称: CARNITINE, Carnitine monooxygenase oxygenase subunit, FE (III) ION, ...
著者Quareshy, M, Shanmugam, M, Bugg, T.D, Cameron, A, Chen, Y.
登録日2020-03-06
公開日2021-03-31
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenase CntA catalytic site.
Febs J., 2023

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件を2024-08-28に公開中

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