6V4T

MPER-TMD of HIV-1 Env bound with the entry inhibitor S2C3

Summary for 6V4T

• Entry DOI: 10.2210/pdb6v4t/pdb
• Related: 6E8W
• NMR Information: BMRB: 30503
• Descriptor: Envelope glycoprotein gp160, 4,4'-(decane-1,10-diyl)bis(9-amino-2,3-dihydro-1H-cyclopenta[b]quinolin-4-ium) (2 entities in total)
• Functional Keywords: hiv-1 env, small-molecule, entry inhibitor, mper, viral protein
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 3
• Total formula weight: 20064.34

Authors

Xiao, T.,Frey, G.,Fu, Q.,Lavine, C.L.,Scott, D.A.,Seaman, M.S.,Chou, J.J.,Chen, B. (deposition date: 2019-11-30, release date: 2020-04-01, Last modification date: 2024-05-15)

• Primary citation: Xiao, T.,Frey, G.,Fu, Q.,Lavine, C.L.,Scott, D.A.,Seaman, M.S.,Chou, J.J.,Chen, B.; HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes.; Nat.Chem.Biol., 16:529-537, 2020; PubMed: 32152540; DOI: 10.1038/s41589-020-0496-y

Experimental method

SOLUTION NMR