7NNA
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7QI3
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![BU of 7qi3 by Molmil](/molmil-images/mine/7qi3) | Structure of Fusarium verticillioides NAT1 (FDB2) N-malonyltransferase | Descriptor: | 1,2-ETHANEDIOL, Arylamine N-acetyltransferase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Lowe, E.D, Kotomina, E, Karagianni, E, Boukouvala, S. | Deposit date: | 2021-12-14 | Release date: | 2022-11-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Fusarium verticillioides NAT1 (FDB2) N-malonyltransferase is structurally, functionally and phylogenetically distinct from its N-acetyltransferase (NAT) homologues. Febs J., 290, 2023
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2PHK
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![BU of 2phk by Molmil](/molmil-images/mine/2phk) | THE CRYSTAL STRUCTURE OF A PHOSPHORYLASE KINASE PEPTIDE SUBSTRATE COMPLEX: KINASE SUBSTRATE RECOGNITION | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Lowe, E.D, Noble, M.E.M, Skamnaki, V.T, Oikonomakos, N.G, Owen, D.J, Johnson, L.N. | Deposit date: | 1998-06-18 | Release date: | 1999-01-13 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition. EMBO J., 16, 1997
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1W98
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![BU of 1w98 by Molmil](/molmil-images/mine/1w98) | The structural basis of CDK2 activation by cyclin E | Descriptor: | CELL DIVISION PROTEIN KINASE 2, G1/S-SPECIFIC CYCLIN E1 | Authors: | Lowe, E.D, Honda, R, Dubinina, E, Skamnaki, V, Cook, A, Johnson, L.N. | Deposit date: | 2004-10-07 | Release date: | 2005-02-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The Structure of Cyclin E1/Cdk2: Implications for Cdk2 Activation and Cdk2-Independent Roles Embo J., 24, 2005
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2BWB
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![BU of 2bwb by Molmil](/molmil-images/mine/2bwb) | Crystal structure of the UBA domain of Dsk2 from S. cerevisiae | Descriptor: | UBIQUITIN-LIKE PROTEIN DSK2 | Authors: | Lowe, E.D, Hasan, N, Trempe, J.-F, Fonso, L, Noble, M.E.M, Endicott, J.A, Johnson, L.N, Brown, N.R. | Deposit date: | 2005-07-13 | Release date: | 2006-01-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of the Dsk2 Ubl and Uba Domains and Their Complex. Acta Crystallogr.,Sect.D, 62, 2006
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2BWF
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![BU of 2bwf by Molmil](/molmil-images/mine/2bwf) | Crystal structure of the UBL domain of Dsk2 from S. cerevisiae | Descriptor: | FORMIC ACID, UBIQUITIN-LIKE PROTEIN DSK2 | Authors: | Lowe, E.D, Hasan, N, Trempe, J.-F, Fonso, L, Noble, M.E.M, Endicott, J.A, Johnson, L.N, Brown, N.R. | Deposit date: | 2005-07-13 | Release date: | 2006-01-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Structures of the Dsk2 Ubl and Uba Domains and Their Complex. Acta Crystallogr.,Sect.D, 62, 2006
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2BWE
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![BU of 2bwe by Molmil](/molmil-images/mine/2bwe) | The crystal structure of the complex between the UBA and UBL domains of Dsk2 | Descriptor: | DSK2 | Authors: | Lowe, E.D, Hasan, N, Trempe, J.-F, Fonso, L, Noble, M.E.M, Endicott, J.A, Johnson, L.N, Brown, N.R. | Deposit date: | 2005-07-13 | Release date: | 2006-01-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of the Dsk2 Ubl and Uba Domains and Their Complex. Acta Crystallogr.,Sect.D, 62, 2006
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2VLE
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![BU of 2vle by Molmil](/molmil-images/mine/2vle) | The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase | Descriptor: | ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL, DAIDZIN | Authors: | Lowe, E.D, Gao, G.Y, Johnson, L.N, Keung, W.M. | Deposit date: | 2008-01-13 | Release date: | 2008-08-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of Daidzin, a Naturally Occurring Anti-Alcohol-Addiction Agent, in Complex with Human Mitochondrial Aldehyde Dehydrogenase. J.Med.Chem., 51, 2008
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4V3E
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![BU of 4v3e by Molmil](/molmil-images/mine/4v3e) | The CIDRa domain from IT4var07 PfEMP1 bound to endothelial protein C receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ... | Authors: | Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K. | Deposit date: | 2014-10-17 | Release date: | 2014-12-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria. Cell Host Microbe., 17, 2015
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7VCE
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![BU of 7vce by Molmil](/molmil-images/mine/7vce) | Structural studies of human inositol monophosphatase-1 inhibition by ebselen | Descriptor: | Inositol monophosphatase 1 | Authors: | Abuhammad, A, Laurieri, N, Rice, A, Lowe, E.D, McDonough, M.A, Singh, N, Churchill, G.C. | Deposit date: | 2021-09-02 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and biochemical analysis of human inositol monophosphatase-1 inhibition by ebselen. J.Biomol.Struct.Dyn., 2023
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4V3D
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![BU of 4v3d by Molmil](/molmil-images/mine/4v3d) | The CIDRa domain from HB3var03 PfEMP1 bound to endothelial protein C receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ... | Authors: | Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K. | Deposit date: | 2014-10-17 | Release date: | 2014-12-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria. Cell Host Microbe., 17, 2015
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6THK
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6NLR
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![BU of 6nlr by Molmil](/molmil-images/mine/6nlr) | Crystal structure of the putative histidinol phosphatase hisK from Listeria monocytogenes with trinuclear metals determined by PIXE revealing sulphate ion in active site. Based on PIXE analysis and original date from 3DCP | Descriptor: | CALCIUM ION, COBALT (II) ION, FE (III) ION, ... | Authors: | Snell, E.H, Garman, E.F, Lowe, E.D. | Deposit date: | 2019-01-09 | Release date: | 2019-12-25 | Last modified: | 2020-01-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application. J.Am.Chem.Soc., 142, 2020
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6XZ1
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![BU of 6xz1 by Molmil](/molmil-images/mine/6xz1) | Conjugate of the HECT domain of HUWE1 with ubiquitin | Descriptor: | HECT, UBA and WWE domain containing 1, isoform CRA_a, ... | Authors: | Liu, B, Seenivasan, A, Nair, R, Chen, D, Lowe, E.D, Lorenz, S. | Deposit date: | 2020-01-31 | Release date: | 2021-08-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe. Acs Chem.Biol., 16, 2021
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6OE2
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6OBY
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4X0J
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![BU of 4x0j by Molmil](/molmil-images/mine/4x0j) | Trypanosoma brucei haptoglobin-haemoglobin receptor | Descriptor: | Haptoglobin-hemoglobin receptor | Authors: | Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K. | Deposit date: | 2014-11-21 | Release date: | 2014-12-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor. Elife, 3, 2014
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4X0L
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![BU of 4x0l by Molmil](/molmil-images/mine/4x0l) | Human haptoglobin-haemoglobin complex | Descriptor: | CACODYLATE ION, GLYCEROL, Haptoglobin, ... | Authors: | Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K. | Deposit date: | 2014-11-21 | Release date: | 2014-12-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor. Elife, 3, 2014
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6FB3
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![BU of 6fb3 by Molmil](/molmil-images/mine/6fb3) | Teneurin 2 Partial Extracellular Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Teneurin-2, ... | Authors: | Jackson, V.A, Carrasquero, M, Lowe, E.D, Seiradake, E. | Deposit date: | 2017-12-18 | Release date: | 2018-03-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction. Nat Commun, 9, 2018
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6ZPK
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![BU of 6zpk by Molmil](/molmil-images/mine/6zpk) | Crystal structure of the unconventional kinetochore protein Trypanosoma brucei KKT4 BRCT domain | Descriptor: | GLYCEROL, SULFATE ION, Trypanosoma brucei KKT4 463-645 | Authors: | Ludzia, P, Lowe, E.D, Marciano, G, Mohammed, S, Redfield, C, Akiyoshi, B. | Deposit date: | 2020-07-08 | Release date: | 2020-10-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Structural characterization of KKT4, an unconventional microtubule-binding kinetochore protein. Structure, 29, 2021
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6ZPJ
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![BU of 6zpj by Molmil](/molmil-images/mine/6zpj) | Crystal structure of the unconventional kinetochore protein Leishmania mexicana KKT4 coiled coil domain | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, IMIDAZOLE, Leishmania mexicana KKT4 | Authors: | Ludzia, P, Lowe, E.D, Marciano, G, Mohammed, S, Redfield, C, Akiyoshi, B. | Deposit date: | 2020-07-08 | Release date: | 2020-10-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural characterization of KKT4, an unconventional microtubule-binding kinetochore protein. Structure, 29, 2021
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5JZS
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![BU of 5jzs by Molmil](/molmil-images/mine/5jzs) | HsaD bound to 3,5-dichloro-4-hydroxybenzoic acid | Descriptor: | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD, 3,5-dichloro-4-hydroxybenzoic acid | Authors: | Ryan, A, Polycarpou, E, Lack, N, Evangelopoulos, D, Sieg, C, Halman, A, Bhakta, S, Sinclair, A, Eleftheriadou, O, McHugh, T.D, Keany, S, Lowe, E.D, Ballet, R, Abuhammad, A, Ciulli, A, Sim, E. | Deposit date: | 2016-05-17 | Release date: | 2017-04-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach. Br. J. Pharmacol., 174, 2017
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2Y3E
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![BU of 2y3e by Molmil](/molmil-images/mine/2y3e) | Traptavidin, apo-form | Descriptor: | GLYCEROL, STREPTAVIDIN | Authors: | Chivers, C.E, Koner, A.L, Lowe, E.D, Howarth, M. | Deposit date: | 2010-12-20 | Release date: | 2011-02-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.449 Å) | Cite: | How the Biotin-Streptavidin Interaction Was Made Even Stronger: Investigation Via Crystallography and a Chimeric Tetramer. Biochem.J., 435, 2011
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2Y3F
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![BU of 2y3f by Molmil](/molmil-images/mine/2y3f) | Traptavidin, biotin bound form | Descriptor: | BIOTIN, GLYCEROL, STREPTAVIDIN | Authors: | Chivers, C.E, Koner, A.L, Lowe, E.D, Howarth, M. | Deposit date: | 2010-12-20 | Release date: | 2011-02-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.493 Å) | Cite: | How the Biotin-Streptavidin Interaction Was Made Even Stronger: Investigation Via Crystallography and a Chimeric Tetramer. Biochem.J., 435, 2011
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3BLQ
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![BU of 3blq by Molmil](/molmil-images/mine/3blq) | Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Cell division protein kinase 9, ... | Authors: | Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N. | Deposit date: | 2007-12-11 | Release date: | 2008-07-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation Embo J., 27, 2008
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