2VLE

The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase

Replaces:  1OF7

Summary for 2VLE

• Entry DOI: 10.2210/pdb2vle/pdb
• Related: 1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM
• Descriptor: ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL, DAIDZIN (3 entities in total)
• Functional Keywords: transit peptide, aldehyde dehydrogenase, nad, daidzin, acetylation, polymorphism, mitochondrion, alcohol abuse, oxidoreductase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Mitochondrion matrix: P05091
• Total number of polymer chains: 8
• Total formula weight: 435091.74

Authors

Lowe, E.D.,Gao, G.Y.,Johnson, L.N.,Keung, W.M. (deposition date: 2008-01-13, release date: 2008-08-19, Last modification date: 2023-12-13)

• Primary citation: Lowe, E.D.,Gao, G.Y.,Johnson, L.N.,Keung, W.M.; Structure of Daidzin, a Naturally Occurring Anti-Alcohol-Addiction Agent, in Complex with Human Mitochondrial Aldehyde Dehydrogenase.; J.Med.Chem., 51:4482-, 2008; PubMed: 18613661; DOI: 10.1021/JM800488J

Experimental method

X-RAY DIFFRACTION (2.4 Å)