3RF4
| Ancylostoma ceylanicum mif in complex with furosemide | 分子名称: | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, ACETATE ION, IMIDAZOLE, ... | 著者 | Cho, Y, Lolis, E. | 登録日 | 2011-04-05 | 公開日 | 2011-10-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors. Chem.Biol., 18, 2011
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3B6T
| Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686A Mutant in Complex with Quisqualate at 2.1 Resolution | 分子名称: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 2, SULFATE ION | 著者 | Cho, Y, Lolis, E, Howe, J.R. | 登録日 | 2007-10-29 | 公開日 | 2008-02-05 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J.Neurosci., 28, 2008
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5UZY
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3RF5
| Ancylostoma ceylanicum mif in complex with n-(2,3,4,5,6-pentafluoro-benzyl)-4-sulfamoyl-benzamide | 分子名称: | 2-[(furan-2-ylmethyl)amino]benzoic acid, ACETATE ION, IMIDAZOLE, ... | 著者 | Cho, Y, Lolis, E. | 登録日 | 2011-04-05 | 公開日 | 2011-10-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors. Chem.Biol., 18, 2011
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3B6Q
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3B6W
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1A15
| SDF-1ALPHA | 分子名称: | STROMAL DERIVED FACTOR-1ALPHA, SULFATE ION | 著者 | Dealwis, C.G, Fernandez, E.J, Lolis, E. | 登録日 | 1997-12-22 | 公開日 | 1998-08-12 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor. Proc.Natl.Acad.Sci.USA, 95, 1998
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1CA7
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1CGQ
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5BS9
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5BSC
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5BSI
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3B9S
| Macrophage Migration Inhibitory Factor (MIF) complexed with Inhibitor, 4-IPP. | 分子名称: | 4-phenylpyrimidine, GLYCEROL, Macrophage Migration Inhibitory Factor, ... | 著者 | Zierow, S, Crichlow, G, Lolis, E. | 登録日 | 2007-11-06 | 公開日 | 2008-09-23 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res., 68, 2008
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3B64
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2OOW
| MIF Bound to a Fluorinated OXIM Derivative | 分子名称: | 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME, GLYCEROL, ISOPROPYL ALCOHOL, ... | 著者 | Crichlow, G.V, Al-Abed, Y, Lolis, E. | 登録日 | 2007-01-26 | 公開日 | 2007-06-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J.Biol.Chem., 282, 2007
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2NWG
| Structure of CXCL12:heparin disaccharide complex | 分子名称: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Stromal cell-derived factor 1 | 著者 | Murphy, J.W, Cho, Y, Lolis, E. | 登録日 | 2006-11-14 | 公開日 | 2007-02-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structural and Functional Basis of CXCL12 (Stromal Cell-derived Factor-1{alpha}) Binding to Heparin J.Biol.Chem., 282, 2007
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2OOZ
| Macrophage Migration Inhibitory Factor (MIF) Complexed with OXIM6 (an OXIM Derivative Not Containing a Ring in its R-group) | 分子名称: | 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME, GLYCEROL, ISOPROPYL ALCOHOL, ... | 著者 | Crichlow, G.V, Al-Abed, Y, Lolis, E. | 登録日 | 2007-01-26 | 公開日 | 2007-06-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J.Biol.Chem., 282, 2007
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2OOH
| Crystal Structure of MIF bound to a Novel Inhibitor, OXIM-11 | 分子名称: | 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME, GLYCEROL, Macrophage migration inhibitory factor, ... | 著者 | Crichlow, G.V, Al-Abed, Y, Lolis, E. | 登録日 | 2007-01-25 | 公開日 | 2007-06-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J.Biol.Chem., 282, 2007
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2OS5
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2QFJ
| Crystal Structure of First Two RRM Domains of FIR Bound to ssDNA from a Portion of FUSE | 分子名称: | DNA (5'-D(*DTP*DCP*DGP*DGP*DGP*DAP*DTP*DTP*DTP*DTP*DTP*DTP*DAP*DTP*DTP*DTP*DTP*DGP*DTP*DGP*DTP*DTP*DAP*DTP*DT)-3'), FBP-interacting repressor | 著者 | Crichlow, G.V, Yang, Y, Fan, C, Lolis, E, Braddock, D. | 登録日 | 2007-06-27 | 公開日 | 2008-03-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition EMBO J., 27, 2007
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4PKK
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3GV3
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3KAN
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3HP3
| Crystal structure of CXCL12 | 分子名称: | CXCL12 protein, GOLD ION | 著者 | Murphy, J.W, Lolis, E, Xiong, Y, Yuan, H, Crichlow, G. | 登録日 | 2009-06-03 | 公開日 | 2010-01-26 | 最終更新日 | 2018-05-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family Proteins, 78, 2009
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3KER
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