4HRF
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![BU of 4hrf by Molmil](/molmil-images/mine/4hrf) | Atomic structure of DUSP26 | Descriptor: | Dual specificity protein phosphatase 26 | Authors: | Lokareddy, R.K, Bhardwaj, A, Cingolani, G. | Deposit date: | 2012-10-27 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase. Biochemistry, 52, 2013
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7UXE
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![BU of 7uxe by Molmil](/molmil-images/mine/7uxe) | Pseudomonas phage E217 small terminase (TerS) | Descriptor: | Small terminase | Authors: | Lokareddy, R.K, Hou, C.-F.D, Doll, S.G, Li, F, Gillilan, R, Forti, F, Briani, F, Cingolani, G. | Deposit date: | 2022-05-05 | Release date: | 2022-09-28 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Terminase Subunits from the Pseudomonas-Phage E217. J.Mol.Biol., 434, 2022
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4XZR
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4PVZ
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![BU of 4pvz by Molmil](/molmil-images/mine/4pvz) | Structure of yeast importin a bound to the membrane protein Nuclear Localization Signal sequence of INM protein Heh2 | Descriptor: | Importin subunit alpha, Inner nuclear membrane protein HEH2 | Authors: | Lokareddy, R.K, Hapsari, A.R, van Rheenen, M, Bhardwaj, A, Veenhoff, L.M, Cingolani, C. | Deposit date: | 2014-03-18 | Release date: | 2015-08-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Structure, 23, 2015
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5JJ3
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5JJ1
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4YI0
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![BU of 4yi0 by Molmil](/molmil-images/mine/4yi0) | Structure of mouse importin a1 bound to Pom121NLS | Descriptor: | Importin subunit alpha-1, Nuclear envelope pore membrane protein POM 121 | Authors: | Lokareddy, R.K, Cingolani, G. | Deposit date: | 2015-02-27 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.806 Å) | Cite: | Mammalian Pom121 and yeast Heh2 share IBB-like NLSs that support targeting to the inner nuclear membrane To Be Published
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3GZ2
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![BU of 3gz2 by Molmil](/molmil-images/mine/3gz2) | Crystal structure of IpgC in complex with an IpaB peptide | Descriptor: | Chaperone protein ipgC, GLYCEROL, IMIDAZOLE, ... | Authors: | Lokareddy, R.K, Lunelli, M, Kolbe, M. | Deposit date: | 2009-04-06 | Release date: | 2010-04-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Combination of two separate binding domains defines stoichiometry between type III secretion system chaperone IpgC and translocator protein IpaB J.Biol.Chem., 285, 2010
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8DKR
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![BU of 8dkr by Molmil](/molmil-images/mine/8dkr) | |
7N9H
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6XMI
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![BU of 6xmi by Molmil](/molmil-images/mine/6xmi) | Structure of Fab4 bound to P22 TerL(1-33) | Descriptor: | Fab Heavy chain, Fab Light chain, Terminase, ... | Authors: | Cingolani, G, Lokareddy, R, Ko, Y. | Deposit date: | 2020-06-30 | Release date: | 2020-08-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Recognition of an alpha-helical hairpin in P22 large terminase by a synthetic antibody fragment. Acta Crystallogr D Struct Biol, 76, 2020
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6RGV
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6E3B
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6VI1
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![BU of 6vi1 by Molmil](/molmil-images/mine/6vi1) | Structure of Fab4 bound to P22 TerL(1-33) | Descriptor: | Synthetic Fab4 heavy chain, Synthetic Fab4 light chain, Terminase, ... | Authors: | Cingolani, G, Lokareddy, R, Ko, Y. | Deposit date: | 2020-01-11 | Release date: | 2020-09-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Recognition of an alpha-helical hairpin in P22 large terminase by a synthetic antibody fragment. Acta Crystallogr D Struct Biol, 76, 2020
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6W7T
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![BU of 6w7t by Molmil](/molmil-images/mine/6w7t) | Structure of PaP3 small terminase | Descriptor: | small terminase subunit | Authors: | Cingolani, G, Lokareddy, R. | Deposit date: | 2020-03-19 | Release date: | 2020-11-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Biophysical analysis of Pseudomonas-phage PaP3 small terminase suggests a mechanism for sequence-specific DNA-binding by lateral interdigitation. Nucleic Acids Res., 48, 2020
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4NYH
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![BU of 4nyh by Molmil](/molmil-images/mine/4nyh) | Orthorhombic crystal form of pir1 dual specificity phosphatase core | Descriptor: | CHLORIDE ION, PHOSPHATE ION, RNA/RNP complex-1-interacting phosphatase | Authors: | Sankhala, R.S, Lokareddy, R.K, Cingolani, G. | Deposit date: | 2013-12-10 | Release date: | 2014-01-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structure of Human PIR1, an Atypical Dual-Specificity Phosphatase. Biochemistry, 53, 2014
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5HUY
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5HUW
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6VI2
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![BU of 6vi2 by Molmil](/molmil-images/mine/6vi2) | Structure of the unaligned Fab4 | Descriptor: | FAB4 heavy chain, FAB4 light chain | Authors: | Cingolani, G, Lokareddy, R, Ko, Y. | Deposit date: | 2020-01-11 | Release date: | 2020-09-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Recognition of an alpha-helical hairpin in P22 large terminase by a synthetic antibody fragment. Acta Crystallogr D Struct Biol, 76, 2020
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4MBB
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![BU of 4mbb by Molmil](/molmil-images/mine/4mbb) | Cubic crystal form of PIR1 dual specificity phosphatase core | Descriptor: | CHLORIDE ION, PHOSPHATE ION, RNA/RNP complex-1-interacting phosphatase | Authors: | Sankhala, R.S, Lokareddy, R.K, Cingolani, G. | Deposit date: | 2013-08-19 | Release date: | 2013-12-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | Structure of Human PIR1, an Atypical Dual-Specificity Phosphatase. Biochemistry, 53, 2014
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4QLP
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![BU of 4qlp by Molmil](/molmil-images/mine/4qlp) | Atomic structure of tuberculosis necrotizing toxin (TNT) complexed with its immunity factor IFT | Descriptor: | Alanine and proline rich protein, tuberculosis necrotizing toxin (TNT), immunity factor IFT | Authors: | Cingolani, G, Lokareddy, R.K, Sun, J, Siroy, A, Speer, A, Doornbos, K.S, Niederweis, M. | Deposit date: | 2014-06-12 | Release date: | 2015-07-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD. Nat.Struct.Mol.Biol., 22, 2015
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3GYZ
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![BU of 3gyz by Molmil](/molmil-images/mine/3gyz) | Crystal structure of IpgC from Shigella flexneri | Descriptor: | Chaperone protein ipgC, GLYCEROL, SODIUM ION, ... | Authors: | Lunelli, M, Lokareddy, R.K, Zychlinsky, A, Kolbe, M. | Deposit date: | 2009-04-06 | Release date: | 2009-06-16 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | IpaB-IpgC interaction defines binding motif for type III secretion translocator Proc.Natl.Acad.Sci.USA, 106, 2009
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3GZ1
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![BU of 3gz1 by Molmil](/molmil-images/mine/3gz1) | Crystal structure of IpgC in complex with the chaperone binding region of IpaB | Descriptor: | Chaperone protein ipgC, GLYCEROL, Invasin ipaB | Authors: | Lunelli, M, Lokareddy, R.K, Zychlinsky, A, Kolbe, M. | Deposit date: | 2009-04-06 | Release date: | 2009-06-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | IpaB-IpgC interaction defines binding motif for type III secretion translocator Proc.Natl.Acad.Sci.USA, 106, 2009
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5T94
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![BU of 5t94 by Molmil](/molmil-images/mine/5t94) | Crystal structure of Kap60 bound to yeast RCC1 (Prp20) | Descriptor: | Guanine nucleotide exchange factor SRM1, Importin subunit alpha | Authors: | Sankhala, R.S, Lokareddy, R.K, Pumroy, R.A, Cingolani, G. | Deposit date: | 2016-09-09 | Release date: | 2017-09-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.631 Å) | Cite: | Three-dimensional context rather than NLS amino acid sequence determines importin alpha subtype specificity for RCC1. Nat Commun, 8, 2017
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5TBK
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![BU of 5tbk by Molmil](/molmil-images/mine/5tbk) | Crystal structure of human importin a3 bound to RCC1 | Descriptor: | Importin subunit alpha-3, Regulator of chromosome condensation | Authors: | Sankhala, R.S, Lokareddy, R.K, Pumroy, R.A, Cingolani, G. | Deposit date: | 2016-09-12 | Release date: | 2017-09-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Three-dimensional context rather than NLS amino acid sequence determines importin alpha subtype specificity for RCC1. Nat Commun, 8, 2017
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