4MBB

Cubic crystal form of PIR1 dual specificity phosphatase core

Summary for 4MBB

Entry DOI	10.2210/pdb4mbb/pdb
Related	1I9S 1VHR 1YN9 3CM3
Descriptor	RNA/RNP complex-1-interacting phosphatase, CHLORIDE ION, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	atypical dual specificity phosphatase, pir1-core, rna splicing, helical hairpin, ptp-loop, deep catalytic cleft, phosphate-binding loop (p-loop), acidic loop (wpd-loop), rna phosphatase, dual specificity phosphatase, rna-rnp complex-1, dephosphorylation, nucleus, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O75319
Total number of polymer chains	1
Total formula weight	21607.92
Authors	Sankhala, R.S.,Lokareddy, R.K.,Cingolani, G. (deposition date: 2013-08-19, release date: 2013-12-18, Last modification date: 2023-09-20)
Primary citation	Sankhala, R.S.,Lokareddy, R.K.,Cingolani, G. Structure of Human PIR1, an Atypical Dual-Specificity Phosphatase. Biochemistry, 53:862-871, 2014 Cited by PubMed: 24447265 DOI: 10.1021/bi401240x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.849 Å)

Structure validation