8DMM
 
 | | Structure of the vanadate-trapped MsbA bound to KDL | | Descriptor: | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ADP ORTHOVANADATE, ATP-binding transport protein MsbA | | Authors: | Liu, C, Lyu, J, Laganowsky, A.D, Zhao, M. | | Deposit date: | 2022-07-08 | | Release date: | 2022-12-14 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Structural basis for lipid and copper regulation of the ABC transporter MsbA.
Nat Commun, 13, 2022
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5T1J
 | | Crystal Structure of the Tbox DNA binding domain of the transcription factor T-bet | | Descriptor: | DNA, T-box transcription factor TBX21 | | Authors: | Liu, C.F, Brandt, G.S, Hoang, Q, Hwang, E.S, Naumova, N, Lazarevic, V, Dekker, J, Glimcher, L.H, Ringe, D, Petsko, G.A. | | Deposit date: | 2016-08-19 | | Release date: | 2016-10-26 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.947 Å) | | Cite: | Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.
Proc.Natl.Acad.Sci.USA, 113, 2016
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4NDZ
 | | Structure of Maltose Binding Protein fusion to 2-O-Sulfotransferase with bound heptasaccharide and PAP | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Maltose-binding periplasmic protein, Heparan sulfate 2-O-sulfotransferase 1 fusion, ... | | Authors: | Liu, C, Sheng, J, Krahn, J.M, Perera, L, Xu, Y, Hsieh, P, Liu, J, Pedersen, L.C. | | Deposit date: | 2013-10-28 | | Release date: | 2014-03-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.45 Å) | | Cite: | Deciphering the role of 2-O-sulfotransferase in regulating heparan sulfate biosynthesis
To be Published
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8DMO
 | | Structure of open, inward-facing MsbA from E. coli | | Descriptor: | ATP-binding transport protein MsbA | | Authors: | Liu, C, Lyu, J, Laganowsky, A.D, Zhao, M. | | Deposit date: | 2022-07-08 | | Release date: | 2022-12-14 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis for lipid and copper regulation of the ABC transporter MsbA.
Nat Commun, 13, 2022
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4J5F
 | | Crystal Structure of B. thuringiensis AiiA mutant F107W | | Descriptor: | GLYCEROL, N-acyl homoserine lactonase, ZINC ION | | Authors: | Liu, C.F, Liu, D, Momb, J, Thomas, P.W, Lajoie, A, Petsko, G.A, Fast, W, Ringe, D. | | Deposit date: | 2013-02-08 | | Release date: | 2013-06-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-gamma-lactonase from Bacillus thuringiensis.
Biochemistry, 52, 2013
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4J5H
 | | Crystal Structure of B. thuringiensis AiiA mutant F107W with N-decanoyl-L-homoserine bound at the active site | | Descriptor: | GLYCEROL, N-acyl homoserine lactonase, N-decanoyl-L-homoserine, ... | | Authors: | Liu, C.F, Liu, D, Momb, J, Thomas, P.W, Lajoie, A, Petsko, G.A, Fast, W, Ringe, D. | | Deposit date: | 2013-02-08 | | Release date: | 2013-06-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-gamma-lactonase from Bacillus thuringiensis.
Biochemistry, 52, 2013
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8XXW
 | | Fab M2-7 complexed with SARS-Cov2 RBD and human ACE2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, M2-7-Heavy chain, M2-7-Light chain, ... | | Authors: | Liu, C, Xie, Y. | | Deposit date: | 2024-01-19 | | Release date: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Mosaic RBD nanoparticle elicits immunodominant antibody responses across sarbecoviruses.
Cell Rep, 43, 2024
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7F9W
 | | CD25 in complex with Fab | | Descriptor: | Heavy chain of Fab, Interleukin-2 receptor subunit alpha, Light chain of Fab | | Authors: | Liu, C. | | Deposit date: | 2021-07-05 | | Release date: | 2022-01-12 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity.
Sci Rep, 11, 2021
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8GSB
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7E23
 | | SARS-CoV-2 spike in complex with the CA521 neutralizing antibody Fab (focused refinement on Fab-RBD) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CA521 Heavy Chain, CA521 Light Chain, ... | | Authors: | Liu, C, Song, D, Dou, C. | | Deposit date: | 2021-02-04 | | Release date: | 2021-05-05 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure and function analysis of a potent human neutralizing antibody CA521 FALA against SARS-CoV-2.
Commun Biol, 4, 2021
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2WVW
 | | Cryo-EM structure of the RbcL-RbcX complex | | Descriptor: | RBCX PROTEIN, RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN | | Authors: | Liu, C, Young, A.L, Starling-Windhof, A, Bracher, A, Saschenbrecker, S, Rao, B.V, Rao, K.V, Berninghausen, O, Mielke, T, Hartl, F.U, Beckmann, R, Hayer-Hartl, M. | | Deposit date: | 2009-10-20 | | Release date: | 2010-01-19 | | Last modified: | 2019-10-23 | | Method: | ELECTRON MICROSCOPY (9 Å) | | Cite: | Coupled Chaperone Action in Folding and Assembly of Hexadecameric Rubisco
Nature, 463, 2010
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2RI1
 | | Crystal Structure of glucosamine 6-phosphate deaminase (NagB) with GlcN6P from S. mutans | | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-amino-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, Glucosamine-6-phosphate deaminase | | Authors: | Liu, C, Li, D, Su, X.D. | | Deposit date: | 2007-10-10 | | Release date: | 2008-03-25 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Ring-opening mechanism revealed by crystal structures of NagB and its ES intermediate complex
J.Mol.Biol., 379, 2008
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7KFZ
 | | Structure of a ternary KRas(G13D)-SOS complex | | Descriptor: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Liu, C, Moghadamchargari, Z, Laganowsky, A, Zhao, M. | | Deposit date: | 2020-10-15 | | Release date: | 2021-03-31 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants.
Proc.Natl.Acad.Sci.USA, 118, 2021
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5FJB
 | | Cyclophilin A Stabilize HIV-1 Capsid through a Novel Non- canonical Binding Site | | Descriptor: | GAG POLYPROTEIN, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A | | Authors: | Liu, C, Perilla, J.R, Ning, J, Lu, M, Hou, G, Ramalhu, R, Bedwell, G.J, Ahn, J, Shi, J, Gronenborn, A.M, Prevelige Jr, P.E, Rousso, I, Aiken, C, Polenova, T, Schulten, K, Zhang, P. | | Deposit date: | 2015-10-07 | | Release date: | 2016-03-16 | | Last modified: | 2017-08-23 | | Method: | ELECTRON MICROSCOPY (9 Å) | | Cite: | Cyclophilin a Stabilizes the HIV-1 Capsid Through a Novel Non-Canonical Binding Site.
Nat.Commun., 7, 2016
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3LOW
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3LOZ
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3VJC
 | | Crystal structure of the human squalene synthase in complex with zaragozic acid A | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, Squalene synthase, ... | | Authors: | Liu, C.I, Jeng, W.Y, Chang, W.J, Ko, T.P, Wang, A.H.J. | | Deposit date: | 2011-10-14 | | Release date: | 2012-04-11 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
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8SM6
 | | Aerobic, Diiron(III)-metalated SfbO | | Descriptor: | Amidohydrolase family protein, FE (III) ION, SULFATE ION | | Authors: | Liu, C, Powell, M.M, Rittle, J. | | Deposit date: | 2023-04-25 | | Release date: | 2024-01-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Bioinformatic Discovery of a Cambialistic Monooxygenase.
J.Am.Chem.Soc., 146, 2024
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8SM9
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8TXR
 | | E. coli ExoVII(H238A) | | Descriptor: | Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease 7 small subunit | | Authors: | Liu, C, Berger, J.M. | | Deposit date: | 2023-08-24 | | Release date: | 2024-01-31 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of Escherichia coli exonuclease VII.
Proc.Natl.Acad.Sci.USA, 121, 2024
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3VJA
 | | Crystal structure of the human squalene synthase | | Descriptor: | NICKEL (II) ION, Squalene synthase | | Authors: | Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J. | | Deposit date: | 2011-10-14 | | Release date: | 2012-04-11 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
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3VJB
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6ILX
 | | Crystal structure of PETase W159F mutant from Ideonella sakaiensis | | Descriptor: | CHLORIDE ION, Poly(ethylene terephthalate) hydrolase, SODIUM ION | | Authors: | Liu, C.C, Shi, C. | | Deposit date: | 2018-10-20 | | Release date: | 2019-03-27 | | Last modified: | 2020-09-09 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Structural and functional characterization of polyethylene terephthalate hydrolase from Ideonella sakaiensis.
Biochem. Biophys. Res. Commun., 508, 2019
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6ILW
 | | Crystal structure of PETase from Ideonella sakaiensis | | Descriptor: | CHLORIDE ION, Poly(ethylene terephthalate) hydrolase, SODIUM ION | | Authors: | Liu, C.C, Shi, C. | | Deposit date: | 2018-10-19 | | Release date: | 2019-03-27 | | Last modified: | 2020-09-09 | | Method: | X-RAY DIFFRACTION (1.575 Å) | | Cite: | Structural and functional characterization of polyethylene terephthalate hydrolase from Ideonella sakaiensis.
Biochem. Biophys. Res. Commun., 508, 2019
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7E39
 | | SARS-CoV-2 spike in complex with the Ab4 neutralizing antibody (State 3) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Ab4, Light Chain of Ab4, ... | | Authors: | Liu, C. | | Deposit date: | 2021-02-08 | | Release date: | 2021-09-01 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants.
Cell Discov, 7, 2021
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