6XKK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xkk by Molmil](/molmil-images/mine/6xkk) | Cryo-EM structure of the NLRP1-CARD filament | Descriptor: | NACHT, LRR and PYD domains-containing protein 1 | Authors: | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | Deposit date: | 2020-06-26 | Release date: | 2020-11-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12, 2021
|
|
6XKJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xkj by Molmil](/molmil-images/mine/6xkj) | Cryo-EM structure of CARD8-CARD filament | Descriptor: | Caspase recruitment domain-containing protein 8 | Authors: | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | Deposit date: | 2020-06-26 | Release date: | 2020-11-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12, 2021
|
|
7KEU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7keu by Molmil](/molmil-images/mine/7keu) | Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer | Descriptor: | Apoptosis-associated speck-like protein containing a CARD, Caspase-1 | Authors: | Hollingsworth, L.R, David, L, Li, Y, Ruan, J, Wu, H. | Deposit date: | 2020-10-12 | Release date: | 2020-11-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12, 2021
|
|
6X6C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6x6c by Molmil](/molmil-images/mine/6x6c) | Cryo-EM structure of NLRP1-DPP9-VbP complex | Descriptor: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ... | Authors: | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | Deposit date: | 2020-05-27 | Release date: | 2021-03-10 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature, 592, 2021
|
|
6X6A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6x6a by Molmil](/molmil-images/mine/6x6a) | Cryo-EM structure of NLRP1-DPP9 complex | Descriptor: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1 | Authors: | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | Deposit date: | 2020-05-27 | Release date: | 2021-03-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature, 592, 2021
|
|
4PX9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4px9 by Molmil](/molmil-images/mine/4px9) | DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X | Authors: | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | Deposit date: | 2014-03-22 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis. J.Mol.Biol., 427, 2015
|
|
4PXA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pxa by Molmil](/molmil-images/mine/4pxa) | DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X, PHOSPHATE ION | Authors: | Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J. | Deposit date: | 2014-03-22 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis. J.Mol.Biol., 427, 2015
|
|
8K8T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8k8t by Molmil](/molmil-images/mine/8k8t) | Structure of CUL3-RBX1-KLHL22 complex | Descriptor: | Cullin-3, Kelch-like protein 22 | Authors: | Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. | Deposit date: | 2023-07-31 | Release date: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22. Nat Commun, 15, 2024
|
|
8K9I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8k9i by Molmil](/molmil-images/mine/8k9i) | Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | Authors: | Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. | Deposit date: | 2023-08-01 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22. Nat Commun, 15, 2024
|
|
2MAI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mai by Molmil](/molmil-images/mine/2mai) | NMR structure of lassomycin | Descriptor: | Lassomycin | Authors: | Gavrish, E, Sit, C.S, Kandror, O, Spoering, A, Peoples, A, Ling, L, Fetterman, A, Hughes, D, Cao, S, Bissell, A, Torrey, H, Akopian, T, Mueller, A, Epstein, S, Goldberg, A, Clardy, J, Lewis, K. | Deposit date: | 2013-07-09 | Release date: | 2014-05-07 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2. Chem.Biol., 21, 2014
|
|
3KYB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3kyb by Molmil](/molmil-images/mine/3kyb) | |
2FVY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2fvy by Molmil](/molmil-images/mine/2fvy) | High Resolution Glucose Bound Crystal Structure of GGBP | Descriptor: | ACETATE ION, CALCIUM ION, CARBON DIOXIDE, ... | Authors: | Borrok, M.J, Kiessling, L.L, Forest, K.T. | Deposit date: | 2006-01-31 | Release date: | 2007-02-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (0.92 Å) | Cite: | Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures. Protein Sci., 16, 2007
|
|
4WMQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wmq by Molmil](/molmil-images/mine/4wmq) | |
4WN0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wn0 by Molmil](/molmil-images/mine/4wn0) | Xenopus laevis embryonic epidermal lectin in complex with glycerol phosphate | Descriptor: | CALCIUM ION, PENTAETHYLENE GLYCOL, PHOSPHATE ION, ... | Authors: | Wangkanont, K, Kiessling, L.L, Forest, K.T. | Deposit date: | 2014-10-10 | Release date: | 2016-01-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition. J.Biol.Chem., 291, 2016
|
|
6D9C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6d9c by Molmil](/molmil-images/mine/6d9c) | |
6D99
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6d99 by Molmil](/molmil-images/mine/6d99) | |
6D9A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6d9a by Molmil](/molmil-images/mine/6d9a) | |
4WMY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wmy by Molmil](/molmil-images/mine/4wmy) | |
4XGK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4xgk by Molmil](/molmil-images/mine/4xgk) | Crystal structure of UDP-galactopyranose mutase from Corynebacterium diphtheriae in complex with 2-[4-(4-chlorophenyl)-7-(2-thienyl)-2-thia-5,6,8,9-tetrazabicyclo[4.3.0]nona-4,7,9-trien-3-yl]acetic | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, SULFATE ION, UDP-galactopyranose mutase, ... | Authors: | Wangkanont, K, Heroux, A, Forest, K.T, Kiessling, L.L. | Deposit date: | 2014-12-31 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.652 Å) | Cite: | Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents. Acs Chem.Biol., 10, 2015
|
|
8UV0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8uv0 by Molmil](/molmil-images/mine/8uv0) | |
4WMO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wmo by Molmil](/molmil-images/mine/4wmo) | |
5EQD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5eqd by Molmil](/molmil-images/mine/5eqd) | |
5ER9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5er9 by Molmil](/molmil-images/mine/5er9) | |
5EQF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5eqf by Molmil](/molmil-images/mine/5eqf) | Crystal structure of oxidized UDP-galactopyranose mutase from Corynebacterium diphtheriae with UDP bound in closed form | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, UDP-galactopyranose mutase, ... | Authors: | Wangkanont, K, Kiessling, L.L, Forest, K.T. | Deposit date: | 2015-11-12 | Release date: | 2016-11-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.145 Å) | Cite: | Conformational Control of UDP-Galactopyranose Mutase Inhibition. Biochemistry, 56, 2017
|
|
8E1X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8e1x by Molmil](/molmil-images/mine/8e1x) | FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29) | Descriptor: | (5M)-N-methyl-5-{(6M,8S)-5-{[(3S)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide, Fibroblast growth factor receptor 2 | Authors: | Lei, H.-T, Epling, L.B, Deller, M.C. | Deposit date: | 2022-08-11 | Release date: | 2022-11-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3. J.Med.Chem., 65, 2022
|
|