4UFO
| Laboratory evolved variant R-C1B1D33E6 of potato epoxide hydrolase StEH1 | Descriptor: | EPOXIDE HYDROLASE | Authors: | Carlsson, A.J, Bauer, P, Nilsson, M, Dobritzsch, D, Kamerlin, S.C.L, Widersten, M. | Deposit date: | 2015-03-17 | Release date: | 2016-04-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Laboratory Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme-Catalyzed Epoxide Hydrolysis. Chembiochem, 17, 2016
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7XGL
| Quinolinate Phosphoribosyl Transferase (QAPRTase) from Streptomyces pyridomyceticus NRRL B-2517 in Apo form | Descriptor: | CHLORIDE ION, GLYCEROL, Quinolinate Phosphoribosyl Transferase, ... | Authors: | Zhou, Z, Yang, X, Huang, T, Wang, X, Liang, R, Zheng, J, Dai, S, Lin, S, Deng, Z. | Deposit date: | 2022-04-05 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Bifunctional NadC Homologue PyrZ Catalyzes Nicotinic Acid Formation in Pyridomycin Biosynthesis. Acs Chem.Biol., 18, 2023
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7XGM
| Quinolinate Phosphoribosyl Transferase (QAPRTase) from Streptomyces pyridomyceticus NRRL B-2517 in complex with Quinolinic Acid (QA) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, QUINOLINIC ACID, ... | Authors: | Zhou, Z, Yang, X, Huang, T, Wang, X, Liang, R, Zheng, J, Dai, S, Lin, S, Deng, Z. | Deposit date: | 2022-04-05 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Bifunctional NadC Homologue PyrZ Catalyzes Nicotinic Acid Formation in Pyridomycin Biosynthesis. Acs Chem.Biol., 18, 2023
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7XGN
| Quinolinate Phosphoribosyl Transferase (QAPRTase) from Streptomyces pyridomyceticus NRRL B-2517 in complex with Nicotinic Acid (NA) | Descriptor: | CHLORIDE ION, NICOTINIC ACID, Quinolinate Phosphoribosyl Transferase, ... | Authors: | Zhou, Z, Yang, X, Huang, T, Wang, X, Liang, R, Zheng, J, Dai, S, Lin, S, Deng, Z. | Deposit date: | 2022-04-05 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Bifunctional NadC Homologue PyrZ Catalyzes Nicotinic Acid Formation in Pyridomycin Biosynthesis. Acs Chem.Biol., 18, 2023
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7DYD
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7EPC
| Cryo-EM structure of inactive mGlu7 homodimer | Descriptor: | Isoform 3 of Metabotropic glutamate receptor 7 | Authors: | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | Deposit date: | 2021-04-26 | Release date: | 2021-06-23 | Last modified: | 2021-07-07 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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7EPB
| Cryo-EM structure of LY354740-bound mGlu2 homodimer | Descriptor: | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, Anti-RON nanobody, Metabotropic glutamate receptor 2 | Authors: | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | Deposit date: | 2021-04-26 | Release date: | 2021-06-23 | Last modified: | 2021-07-07 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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7EPA
| Cryo-EM structure of inactive mGlu2 homodimer | Descriptor: | Metabotropic glutamate receptor 2 | Authors: | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | Deposit date: | 2021-04-26 | Release date: | 2021-06-23 | Last modified: | 2021-07-07 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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7EPF
| Crystal structure of mGlu2 bound to NAM597 | Descriptor: | (8~{R})-4-[2,4-bis(fluoranyl)phenyl]-8-methyl-7-[(2-methylpyrazol-3-yl)methyl]-6,8-dihydro-5~{H}-1,7-naphthyridine-2-carboxamide, FLAVIN MONONUCLEOTIDE, Metabotropic glutamate receptor 2 | Authors: | Du, J, Wang, D, Lin, S, Han, S, Wu, B, Zhao, Q. | Deposit date: | 2021-04-26 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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7EPD
| Cryo-EM structure of inactive mGlu2-7 heterodimer | Descriptor: | Isoform 3 of Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 2,Peptidylprolyl isomerase | Authors: | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | Deposit date: | 2021-04-26 | Release date: | 2021-06-23 | Last modified: | 2021-07-07 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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7EPE
| Crystal structure of mGlu2 bound to NAM563 | Descriptor: | 4-(1-methylpyrazol-4-yl)-7-[[(2~{S})-2-(trifluoromethyl)morpholin-4-yl]methyl]quinoline-2-carboxamide, FLAVIN MONONUCLEOTIDE, Metabotropic glutamate receptor 2 | Authors: | Du, J, Wang, D, Lin, S, Han, S, Wu, B, Zhao, Q. | Deposit date: | 2021-04-26 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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7X3Z
| Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NAD | Descriptor: | (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, 17-beta-hydroxysteroid dehydrogenase type 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Li, T, Lin, S.X, Yin, H. | Deposit date: | 2022-03-01 | Release date: | 2023-01-25 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | New insights into the substrate inhibition of human 17 beta-hydroxysteroid dehydrogenase type 1. J.Steroid Biochem.Mol.Biol., 228, 2023
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1OV4
| Crystal structure of human DHEA-ST complexed with androsterone | Descriptor: | (3Beta,5alpha)-3-Hydroxyandrostan-17-one, Alcohol sulfotransferase, SULFATE ION | Authors: | Chang, H.J, Shi, R, Rhese, P, Lin, S.X. | Deposit date: | 2003-03-25 | Release date: | 2004-02-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. J.Biol.Chem., 279, 2004
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4UFN
| Laboratory evolved variant R-C1B1 of potato epoxide hydrolase StEH1 | Descriptor: | 1,4-DIETHYLENE DIOXIDE, EPOXIDE HYDROLASE | Authors: | Carlsson, A.J, Bauer, P, Nilsson, M, Dobritzsch, D, Kamerlin, S.C.L, Widersten, M. | Deposit date: | 2015-03-17 | Release date: | 2016-04-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1. Org.Biomol.Chem., 14, 2016
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4W8J
| Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals | Descriptor: | CALCIUM ION, POTASSIUM ION, Pesticidal crystal protein cry1Ac | Authors: | Evdokimov, A.G, Moshiri, F, Sturman, E.J, Rydel, T.J, Zheng, M, Seale, J.W, Franklin, S. | Deposit date: | 2014-08-25 | Release date: | 2014-09-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals. Protein Sci., 23, 2014
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7EAL
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7EAO
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7EB9
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1DHT
| ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED DIHYDROTESTOSTERONE | Descriptor: | 5-ALPHA-DIHYDROTESTOSTERONE, ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE | Authors: | Han, Q, Campbell, R.L, Gangloff, A, Lin, S.X. | Deposit date: | 1998-03-25 | Release date: | 1999-09-25 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain. J.Biol.Chem., 275, 2000
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7ZQJ
| MHC class I from a wild bird in complex with a nonameric peptide P3 | Descriptor: | ACETATE ION, Beta-2-microglobulin, MHC class I antigen, ... | Authors: | Eltschkner, S, Mellinger, S, Buus, S, Nielsen, M, Paulsson, K.M, Lindkvist-Petersson, K, Westerdahl, H. | Deposit date: | 2022-04-29 | Release date: | 2023-05-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The structure of songbird MHC class I reveals antigen binding that is flexible at the N-terminus and static at the C-terminus. Front Immunol, 14, 2023
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2VLC
| Crystal structure of Natural Cinnamomin (Isoform III) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ribosome-inactivating protein, beta-D-mannopyranose, ... | Authors: | Azzi, A, Wang, T, Zhu, D.-W, Zou, Y.-S, Liu, W.-Y, Lin, S.-X. | Deposit date: | 2008-01-11 | Release date: | 2009-02-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Crystal Structure of Native Cinnamomin Isoform III and its Comparison with Other Ribosome Inactivating Proteins. Proteins: Struct., Funct., Bioinf., 74, 2009
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5JW4
| Structure of MEDI8852 Fab Fragment in Complex with H5 HA | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Neu, U, Collins, P.J, Walker, P.A, Vorlaender, M.K, Ogrodowicz, R.W, Martin, S.R, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2016-05-11 | Release date: | 2016-08-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes. Cell, 166, 2016
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7ZQI
| MHC class I from a wild bird in complex with a nonameric peptide P2 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-2-microglobulin, CHLORIDE ION, ... | Authors: | Eltschkner, S, Mellinger, S, Buus, S, Nielsen, M, Paulsson, K.M, Lindkvist-Petersson, K, Westerdahl, H. | Deposit date: | 2022-04-29 | Release date: | 2023-05-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The structure of songbird MHC class I reveals antigen binding that is flexible at the N-terminus and static at the C-terminus. Front Immunol, 14, 2023
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5JW5
| Structure of MEDI8852 Fab Fragment | Descriptor: | MEDI8852 Heavy chain, MEDI8852 Light chain, PHOSPHATE ION | Authors: | Neu, U, Collins, P.J, Walker, P.A, Vorlaender, M.K, Ogrodowicz, R.W, Martin, S.R, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2016-05-11 | Release date: | 2016-08-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes. Cell, 166, 2016
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5JW3
| Structure of MEDI8852 Fab Fragment in Complex with H7 HA | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Collins, P.J, Neu, U, Walker, P.A, Vorlaender, M.K, Ogrodowicz, R.W, Martin, S.R, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2016-05-11 | Release date: | 2016-08-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.75 Å) | Cite: | Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes. Cell, 166, 2016
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