7X3Z

Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NAD

Summary for 7X3Z

• Entry DOI: 10.2210/pdb7x3z/pdb
• Descriptor: 17-beta-hydroxysteroid dehydrogenase type 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, ... (4 entities in total)
• Functional Keywords: 17beta-hsd1, estrone, functional analyses, oxidoreductase, steroid, nad/nadh
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 71575.22

Authors

Li, T.,Lin, S.X.,Yin, H. (deposition date: 2022-03-01, release date: 2023-01-25, Last modification date: 2024-05-29)

• Primary citation: Li, T.,Song, X.,Stephen, P.,Yin, H.,Lin, S.X.; New insights into the substrate inhibition of human 17 beta-hydroxysteroid dehydrogenase type 1.; J.Steroid Biochem.Mol.Biol., 228:106246-106246, 2023; PubMed: 36634828; DOI: 10.1016/j.jsbmb.2023.106246

Experimental method

X-RAY DIFFRACTION (2.25 Å)