5JW4

Structure of MEDI8852 Fab Fragment in Complex with H5 HA

Summary for 5JW4

• Entry DOI: 10.2210/pdb5jw4/pdb
• Descriptor: Hemagglutinin, MEDI8852 heavy chain, MEDI8852 light chain, ... (8 entities in total)
• Functional Keywords: antibody influenza broadly neutralizing, immune system
• Biological source: Influenza A virus (A/Vietnam/1194/2004(H5N1)); More
• Total number of polymer chains: 24
• Total formula weight: 618414.55

Authors

Neu, U.,Collins, P.J.,Walker, P.A.,Vorlaender, M.K.,Ogrodowicz, R.W.,Martin, S.R.,Gamblin, S.J.,Skehel, J.J. (deposition date: 2016-05-11, release date: 2016-08-03, Last modification date: 2024-01-10)

• Primary citation: Kallewaard, N.L.,Corti, D.,Collins, P.J.,Neu, U.,McAuliffe, J.M.,Benjamin, E.,Wachter-Rosati, L.,Palmer-Hill, F.J.,Yuan, A.Q.,Walker, P.A.,Vorlaender, M.K.,Bianchi, S.,Guarino, B.,De Marco, A.,Vanzetta, F.,Agatic, G.,Foglierini, M.,Pinna, D.,Fernandez-Rodriguez, B.,Fruehwirth, A.,Silacci, C.,Ogrodowicz, R.W.,Martin, S.R.,Sallusto, F.,Suzich, J.A.,Lanzavecchia, A.,Zhu, Q.,Gamblin, S.J.,Skehel, J.J.; Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.; Cell, 166:596-608, 2016; PubMed: 27453466; DOI: 10.1016/j.cell.2016.05.073

Experimental method

X-RAY DIFFRACTION (3.7 Å)