5JW4
Structure of MEDI8852 Fab Fragment in Complex with H5 HA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... (A, C, E, G, I...) | Hemagglutinin | polymer | 321 | 36293.1 | 6 | UniProt (Q6DQ34) Pfam (PF00509) | Influenza A virus (A/Vietnam/1194/2004(H5N1)) | |
| 2 | B, D, F, H, J... (B, D, F, H, J...) | Hemagglutinin | polymer | 162 | 18681.6 | 6 | UniProt (Q6DQ34) UniProt (by SIFTS) (Q6DQ18) | Influenza A virus (A/Vietnam/1194/2004(H5N1)) | |
| 3 | M, O, S, U, W (M, O, S, U, W) | MEDI8852 heavy chain | polymer | 227 | 24413.2 | 5 | Homo sapiens (Human) | ||
| 4 | N, P, T, V, X (N, P, T, V, X) | MEDI8852 light chain | polymer | 206 | 22450.8 | 5 | Homo sapiens (Human) | ||
| 5 | Q (Q) | MEDI8852 heavy chain | polymer | 231 | 24789.6 | 1 | Homo sapiens (human) | ||
| 6 | R (R) | MEDI8852 light chain | polymer | 210 | 22910.3 | 1 | Homo sapiens (human) | ||
| 7 | AA, BA, CA, Y, Z (a, b, c, Y, Z) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 8 | DA, EA, FA, GA, HA... (A, C, D, E, G...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 20 | Chemie (NAG) |
Sequence modifications
A, C, E, G, I, K: 1 - 321 (UniProt: Q6DQ34)
| PDB | External Database | Details |
|---|---|---|
| Lys 182 | Asn 198 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 611868.4 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2122.0 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 4424.2 | |
| All* | Total formula weight | 618414.5 |
