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PDB: 351 件
5CL3
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BU of 5cl3 by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing a 3-methyladenine analog (100% substrate at 4 hours)
分子名称: AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(DZM)P*AP*GP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*CP*TP*TP*TP*CP*GP*GP*G)-3')
著者Mullins, E.A, Eichman, B.F.
登録日2015-07-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.971 Å)
主引用文献The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
5CL8
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BU of 5cl8 by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing an abasic site and a free nucleobase (100% product at 144 hours)
分子名称: 7-methyl-3H-imidazo[4,5-c]pyridin-4-amine, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(ORP)P*AP*GP*TP*CP*CP*G)-3'), ...
著者Mullins, E.A, Eichman, B.F.
登録日2015-07-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
5CLE
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BU of 5cle by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing an abasic-site analog and a free 3-methyladenine nucleobase
分子名称: 3-METHYL-3H-PURIN-6-YLAMINE, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(3DR)P*AP*GP*TP*CP*CP*G)-3'), ...
著者Mullins, E.A, Eichman, B.F.
登録日2015-07-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
5CL9
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BU of 5cl9 by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing an abasic site and a free nucleobase (100% product at 240 hours)
分子名称: 7-methyl-3H-imidazo[4,5-c]pyridin-4-amine, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(ORP)P*AP*GP*TP*CP*CP*G)-3'), ...
著者Mullins, E.A, Eichman, B.F.
登録日2015-07-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.538 Å)
主引用文献The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
5CL4
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BU of 5cl4 by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing a 3-methyladenine analog or DNA containing an abasic site and a free nucleobase (71% substrate/29% product at 24 hours)
分子名称: 7-methyl-3H-imidazo[4,5-c]pyridin-4-amine, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(DZM)P*AP*GP*TP*CP*CP*G)-3'), ...
著者Mullins, E.A, Eichman, B.F.
登録日2015-07-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.866 Å)
主引用文献The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
5CL7
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BU of 5cl7 by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing a 3-methyladenine analog or DNA containing an abasic site and a free nucleobase (18% substrate/82% product at 96 hours)
分子名称: 7-methyl-3H-imidazo[4,5-c]pyridin-4-amine, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(DZM)P*AP*GP*TP*CP*CP*G)-3'), ...
著者Mullins, E.A, Eichman, B.F.
登録日2015-07-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
5CLA
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BU of 5cla by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing an abasic site and a free nucleobase (100% product at 360 hours)
分子名称: 7-methyl-3H-imidazo[4,5-c]pyridin-4-amine, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(ORP)P*AP*GP*TP*CP*CP*G)-3'), ...
著者Mullins, E.A, Eichman, B.F.
登録日2015-07-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.541 Å)
主引用文献The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
5CLD
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BU of 5cld by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing an oxocarbenium-intermediate analog and a free 3-methyladenine nucleobase
分子名称: 3-METHYL-3H-PURIN-6-YLAMINE, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(NRI)P*AP*GP*TP*CP*CP*G)-3'), ...
著者Mullins, E.A, Eichman, B.F.
登録日2015-07-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.541 Å)
主引用文献The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
5CL5
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BU of 5cl5 by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing a 3-methyladenine analog or DNA containing an abasic site and a free nucleobase (51% substrate/49% product at 48 hours)
分子名称: 7-methyl-3H-imidazo[4,5-c]pyridin-4-amine, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(DZM)P*AP*GP*TP*CP*CP*G)-3'), ...
著者Mullins, E.A, Eichman, B.F.
登録日2015-07-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.569 Å)
主引用文献The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
5CLC
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BU of 5clc by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing a 3-methyladenine analog (9-mer B)
分子名称: AlkD, DNA (5'-D(*AP*AP*GP*CP*CP*(DZM)P*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*TP*GP*GP*CP*T)-3')
著者Mullins, E.A, Eichman, B.F.
登録日2015-07-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.729 Å)
主引用文献The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
5CL6
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BU of 5cl6 by Molmil
Alkylpurine DNA glycosylase AlkD bound to DNA containing a 3-methyladenine analog or DNA containing an abasic site and a free nucleobase (33% substrate/67% product at 72 hours)
分子名称: 7-methyl-3H-imidazo[4,5-c]pyridin-4-amine, AlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(DZM)P*AP*GP*TP*CP*CP*G)-3'), ...
著者Mullins, E.A, Eichman, B.F.
登録日2015-07-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.541 Å)
主引用文献The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527, 2015
7LXJ
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BU of 7lxj by Molmil
Bacillus cereus DNA glycosylase AlkD bound to a duocarmycin SA-adenine nucleobase adduct and DNA containing an abasic site
分子名称: CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*AP*(ORP)P*GP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*CP*TP*TP*TP*GP*C)-3'), ...
著者Mullins, E.A, Eichman, B.F.
登録日2021-03-03
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites.
Nat Commun, 12, 2021
6TNO
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BU of 6tno by Molmil
Crystal structure of the human Arc N-lobe bound to stargazin
分子名称: Arc_C domain-containing protein, Chains: B,D,F
著者Hallin, E.I, Bramham, C.R, Kursula, P.
登録日2019-12-09
公開日2020-12-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural properties and peptide ligand binding of the capsid homology domains of human Arc.
Biochem Biophys Rep, 26, 2021
6TNQ
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BU of 6tnq by Molmil
Crystal structure of the human Arc N-lobe bound to repeat 4 from GKAP
分子名称: ACETYL GROUP, Activity-regulated cytoskeleton-associated protein, Chains: B,D,F
著者Hallin, E.I, Bramham, C.R, Kursula, P.
登録日2019-12-10
公開日2021-01-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structural properties and peptide ligand binding of the capsid homology domains of human Arc.
Biochem Biophys Rep, 26, 2021
3KFY
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BU of 3kfy by Molmil
Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR
分子名称: 5-[(4-chlorophenyl)sulfanyl]quinazoline-2,4-diamine, CALCIUM ION, Dihydrofolate reductase, ...
著者Collins, E.J, Lee, A.L, Carroll, M.J, Gromova, A.V, Miller, K.R, Singleton, S.F.
登録日2009-10-28
公開日2010-12-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR
To be Published
7QFN
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BU of 7qfn by Molmil
Human Topoisomerase II Beta ATPase ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA topoisomerase 2-beta, MAGNESIUM ION, ...
著者Ling, E.M, Basle, A, Cowell, I.G, Blower, T.R, Austin, C.A.
登録日2021-12-06
公開日2022-05-25
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.621 Å)
主引用文献A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.
Structure, 30, 2022
7QFO
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BU of 7qfo by Molmil
Human Topoisomerase II Beta ATPase AMPPNP
分子名称: ALANINE, DNA topoisomerase 2-beta, MAGNESIUM ION, ...
著者Ling, E.M, Basle, A, Cowell, I.G, Blower, T.R, Austin, C.A.
登録日2021-12-06
公開日2022-05-25
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.
Structure, 30, 2022
1TMC
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BU of 1tmc by Molmil
THE THREE-DIMENSIONAL STRUCTURE OF A CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE MISSING THE ALPHA3 DOMAIN OF THE HEAVY CHAIN
分子名称: BETA 2-MICROGLOBULIN, CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-AW68), DECAMERIC PEPTIDE (EVAPPEYHRK)
著者Collins, E.J, Garboczi, D.N, Karpusas, M.N, Wiley, D.C.
登録日1994-12-19
公開日1995-03-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain.
Proc.Natl.Acad.Sci.USA, 92, 1995
7ZBG
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BU of 7zbg by Molmil
Human Topoisomerase II Beta ATPase ADP
分子名称: 4-[(2S,3R)-3-[3,5-bis(oxidanylidene)piperazin-1-ium-1-yl]butan-2-yl]piperazin-4-ium-2,6-dione, ADENOSINE-5'-DIPHOSPHATE, DNA topoisomerase 2-beta, ...
著者Ling, E.M, Basle, A, Cowell, I.G, Blower, T.R, Austin, C.A.
登録日2022-03-23
公開日2022-05-25
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.
Structure, 30, 2022
6TN7
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BU of 6tn7 by Molmil
Crystal structure of the human Arc C-lobe
分子名称: Activity-regulated cytoskeleton-associated protein, GLYCEROL
著者Hallin, E.I, Bramham, C.R, Kursula, P.
登録日2019-12-06
公開日2020-12-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Structural properties and peptide ligand binding of the capsid homology domains of human Arc.
Biochem Biophys Rep, 26, 2021
3V5D
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BU of 3v5d by Molmil
HLA-A2.1 KVAELVHFL
分子名称: Beta-2-microglobulin, HIV peptide KVAELVHFL, HLA class I histocompatibility antigen, ...
著者Collins, E.J, Lee, H.Y.
登録日2011-12-16
公開日2012-12-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Prediction of conformation and immunogenicity of peptides bound to MHC molecules
To be Published
3V5K
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BU of 3v5k by Molmil
HLA2.1 KVAELVWFL
分子名称: Beta-2-microglobulin, GLYCEROL, HIV-based altered-peptide ligand KVAELVWFL, ...
著者Collins, E.J, Lee, H.Y.
登録日2011-12-16
公開日2012-12-19
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Prediction of Immunogenicity of altered-peptide ligands to HIV bound to MHC
To be Published
3V5H
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BU of 3v5h by Molmil
HLA-A2.1 KVAEIVHFL
分子名称: Beta-2-microglobulin, GLYCEROL, HIV-based altered-peptide ligand KVAEIVHFL, ...
著者Collins, E.J, Lee, H.Y.
登録日2011-12-16
公開日2012-12-05
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Prediction of immunogenicity of altered-peptide ligands for HIV therapy
To be Published
3QYO
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BU of 3qyo by Molmil
Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate
分子名称: CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Collins, E.J, Lee, A.L, Carroll, M.J, Mauldin, R.V, Gromova, A.V, Singleton, S.F.
登録日2011-03-03
公開日2012-01-18
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Evidence for dynamics in proteins as a mechanism for ligand dissociation.
Nat.Chem.Biol., 8, 2012
3R33
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BU of 3r33 by Molmil
Evidence for dynamic motion in proteins as a mechanism for ligand dissociation
分子名称: (6S)-6-methyl-5,6,7,8-tetrahydroquinazoline-2,4-diamine, CALCIUM ION, CHLORIDE ION, ...
著者Collins, E.J, Lee, A.L, Carroll, M.J, Mauldin, R.V, Gromova, A.V, Singleton, S.F.
登録日2011-03-15
公開日2012-01-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Evidence for dynamics in proteins as a mechanism for ligand dissociation.
Nat.Chem.Biol., 8, 2012

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