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5CL3

Alkylpurine DNA glycosylase AlkD bound to DNA containing a 3-methyladenine analog (100% substrate at 4 hours)

Summary for 5CL3
Entry DOI10.2210/pdb5cl3/pdb
Related5CL4 5CL5 5CL6 5CL7 5CL8 5CL9 5CLA 5CLB 5CLC 5CLD 5CLE
DescriptorAlkD, DNA (5'-D(*CP*CP*CP*GP*AP*(DZM)P*AP*GP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*CP*TP*TP*TP*CP*GP*GP*G)-3'), ... (4 entities in total)
Functional Keywordsdna glycosylase, heat-like repeat, protein-dna complex, hydrolase-dna complex, hydrolase/dna
Biological sourceBacillus cereus
More
Total number of polymer chains3
Total formula weight35058.91
Authors
Mullins, E.A.,Eichman, B.F. (deposition date: 2015-07-16, release date: 2015-10-28, Last modification date: 2023-09-27)
Primary citationMullins, E.A.,Shi, R.,Parsons, Z.D.,Yuen, P.K.,David, S.S.,Igarashi, Y.,Eichman, B.F.
The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Nature, 527:254-258, 2015
Cited by
PubMed: 26524531
DOI: 10.1038/nature15728
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.971 Å)
Structure validation

217705

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