3R33

Evidence for dynamic motion in proteins as a mechanism for ligand dissociation

Summary for 3R33

Entry DOI	10.2210/pdb3r33/pdb
Descriptor	Dihydrofolate reductase, (6S)-6-methyl-5,6,7,8-tetrahydroquinazoline-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywords	rossmann fold, reductase, oxidoreductase
Biological source	Escherichia coli K-12
Total number of polymer chains	1
Total formula weight	19731.67
Authors	Collins, E.J.,Lee, A.L.,Carroll, M.J.,Mauldin, R.V.,Gromova, A.V.,Singleton, S.F. (deposition date: 2011-03-15, release date: 2012-01-25, Last modification date: 2024-02-21)
Primary citation	Carroll, M.J.,Mauldin, R.V.,Gromova, A.V.,Singleton, S.F.,Collins, E.J.,Lee, A.L. Evidence for dynamics in proteins as a mechanism for ligand dissociation. Nat.Chem.Biol., 8:246-252, 2012 Cited by PubMed: 22246400 DOI: 10.1038/nchembio.769 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation