7LXJ

Bacillus cereus DNA glycosylase AlkD bound to a duocarmycin SA-adenine nucleobase adduct and DNA containing an abasic site

Summary for 7LXJ

• Entry DOI: 10.2210/pdb7lxj/pdb
• Related: 5UUG 7LXH
• Descriptor: DNA-7-methylguanine glycosylase, DNA (5'-D(*AP*GP*CP*AP*AP*(ORP)P*GP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*CP*TP*TP*TP*GP*C)-3'), ... (6 entities in total)
• Functional Keywords: dna repair, base excision repair, antibiotic self-resistance, bulky dna adduct, secondary metabolite, dna binding protein, hydrolase-dna-antibiotic complex, hydrolase/dna/antibiotic
• Biological source: Bacillus cereus; More
• Total number of polymer chains: 3
• Total formula weight: 34625.30

Authors

Mullins, E.A.,Eichman, B.F. (deposition date: 2021-03-03, release date: 2021-11-17, Last modification date: 2023-10-18)

• Primary citation: Mullins, E.A.,Dorival, J.,Tang, G.L.,Boger, D.L.,Eichman, B.F.; Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites.; Nat Commun, 12:6942-6942, 2021; PubMed: 34836957; DOI: 10.1038/s41467-021-27284-7

Experimental method

X-RAY DIFFRACTION (1.93 Å)