4QKW
 
 | | Crystal structure of the zebrafish cavin4a HR1 domain | | Descriptor: | CHLORIDE ION, Muscle-related coiled-coil protein | | Authors: | Kovtun, O, Tillu, V, Parton, R.G, Collins, B.M. | | Deposit date: | 2014-06-10 | | Release date: | 2015-03-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural insights into the organization of the cavin membrane coat complex
Dev.Cell, 31, 2014
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3OGO
 | | Structure of the GFP:GFP-nanobody complex at 2.8 A resolution in spacegroup P21212 | | Descriptor: | GFP-nanobody, Green fluorescent protein, ISOPROPYL ALCOHOL | | Authors: | Kubala, M.H, Kovtun, O, Alexandrov, K, Collins, B.M. | | Deposit date: | 2010-08-17 | | Release date: | 2010-08-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural and thermodynamic analysis of the GFP:GFP-nanobody complex.
Protein Sci., 19, 2010
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4I8A
 | | Alanine-glyoxylate aminotransferase variant S187F | | Descriptor: | GLYCEROL, Serine-pyruvate aminotransferase | | Authors: | Fodor, K, Oppici, E, Williams, C, Cellini, B, Wilmanns, M. | | Deposit date: | 2012-12-03 | | Release date: | 2013-05-01 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implications.
Proteins, 81, 2013
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1QH5
 | | HUMAN GLYOXALASE II WITH S-(N-HYDROXY-N-BROMOPHENYLCARBAMOYL)GLUTATHIONE | | Descriptor: | GLUTATHIONE, PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE), S-(N-HYDROXY-N-BROMOPHENYLCARBAMOYL)GLUTATHIONE, ... | | Authors: | Cameron, A.D, Ridderstrom, M, Olin, B, Mannervik, B. | | Deposit date: | 1999-05-11 | | Release date: | 1999-09-24 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
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1QH3
 | | HUMAN GLYOXALASE II WITH CACODYLATE AND ACETATE IONS PRESENT IN THE ACTIVE SITE | | Descriptor: | ACETATE ION, CACODYLATE ION, CHLORIDE ION, ... | | Authors: | Cameron, A.D, Ridderstrom, M, Olin, B, Mannervik, B. | | Deposit date: | 1999-05-10 | | Release date: | 1999-09-24 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
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8AYF
 | | Crystal structure of human Sphingosine-1-phosphate lyase 1 | | Descriptor: | ACETATE ION, GLYCEROL, Sphingosine-1-phosphate lyase 1 | | Authors: | Giardina, G, Catalano, F, Pampalone, G, Cellini, B. | | Deposit date: | 2022-09-02 | | Release date: | 2023-09-13 | | Last modified: | 2024-01-03 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study.
Sci Rep, 13, 2023
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3HDS
 | | Crystal structure of 4-methylmuconolactone methylisomerase in complex with MES | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-methylmuconolactone methylisomerase, short peptide ASWSA | | Authors: | Marin, M, Heinz, D.W, Pieper, D.H, Klink, B.U. | | Deposit date: | 2009-05-07 | | Release date: | 2009-09-29 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Crystal structure and catalytic mechanism of 4-methylmuconolactone methylisomerase
J.Biol.Chem., 284, 2009
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6RV1
 | | human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) | | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase | | Authors: | Giardina, G, Cutruzzola, F, Cellini, B, Mirco, D. | | Deposit date: | 2019-05-30 | | Release date: | 2020-04-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 1.
Biochem.J., 476, 2019
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1XE8
 | | Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly roll fold. | | Descriptor: | ADENINE, CITRIC ACID, GLYCEROL, ... | | Authors: | Zhou, C.-Z, Meyer, P, Quevillon-Cheruel, S, Li de La Sierra-Gallay, I, Collinet, B, Graille, M, Leulliot, N, Sorel, I, Janin, J, Van Tilbeurgh, H. | | Deposit date: | 2004-09-09 | | Release date: | 2005-01-11 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly-roll fold
Protein Sci., 14, 2005
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2XTS
 | | Crystal Structure of the Sulfane Dehydrogenase SoxCD from Paracoccus pantotrophus | | Descriptor: | CALCIUM ION, COBALT (II) ION, CYTOCHROME, ... | | Authors: | Zander, U, Faust, A, Klink, B.U, de Sanctis, D, Panjikar, S, Quentmeier, A, Bardischewski, F, Friedrich, C.G, Scheidig, A.J. | | Deposit date: | 2010-10-12 | | Release date: | 2010-12-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Structural Basis for the Oxidation of Protein-Bound Sulfur by the Sulfur Cycle Molybdohemo-Enzyme Sulfane Dehydrogenase Soxcd.
J.Biol.Chem., 286, 2011
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5E7B
 | | Structure of a nanobody (vHH) from camel against phage Tuc2009 RBP (BppL, ORF53) | | Descriptor: | nanobody nano-L06 | | Authors: | Legrand, P, Collins, B, Blangy, S, Murphy, J, Spinelli, S, Gutierrez, C, Richet, N, Kellenberger, C, Desmyter, A, Mahony, J, van Sinderen, D, Cambillau, C. | | Deposit date: | 2015-10-12 | | Release date: | 2015-12-30 | | Last modified: | 2016-05-04 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules.
Mbio, 7, 2016
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2C3T
 | | Human glutathione-S-transferase T1-1, W234R mutant, apo form | | Descriptor: | GLUTATHIONE S-TRANSFERASE THETA 1 | | Authors: | Tars, K, Larsson, A.-K, Shokeer, A, Olin, B, Mannervik, B, Kleywegt, G.J. | | Deposit date: | 2005-10-12 | | Release date: | 2005-11-30 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis of the Suppressed Catalytic Activity of Wild-Type Human Glutathione Transferase T1-1 Compared to its W234R Mutant.
J.Mol.Biol., 355, 2006
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2C3N
 | | Human glutathione-S-transferase T1-1, apo form | | Descriptor: | GLUTATHIONE S-TRANSFERASE THETA 1, IODIDE ION | | Authors: | Tars, K, Larsson, A.-K, Shokeer, A, Olin, B, Mannervik, B, Kleywegt, G.J. | | Deposit date: | 2005-10-11 | | Release date: | 2005-11-30 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural Basis of the Suppressed Catalytic Activity of Wild-Type Human Glutathione Transferase T1-1 Compared to its W234R Mutant.
J.Mol.Biol., 355, 2006
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2C4J
 | | Human glutathione-S-transferase M2-2 T210S mutant in complex with glutathione-styrene oxide conjugate | | Descriptor: | GLUTATHIONE S-TRANSFERASE MU 2, L-GAMMA-GLUTAMYL-S-[(2S)-2-HYDROXY-2-PHENYLETHYL]-L-CYSTEINYLGLYCINE | | Authors: | Tars, K, Andersson, M, Ivarsson, Y, Olin, B, Mannervik, B. | | Deposit date: | 2005-10-20 | | Release date: | 2005-10-26 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Alternative Mutations of a Positively Selected Residue Elicit Gain or Loss of Functionalities in Enzyme Evolution.
Proc.Natl.Acad.Sci.USA, 103, 2006
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6BTZ
 | | Crystal structure of the PI3KC2alpha C2 domain in space group C121 | | Descriptor: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, GLYCEROL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ... | | Authors: | Chen, K.-E, Collins, B.M. | | Deposit date: | 2017-12-08 | | Release date: | 2018-10-17 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2 alpha.
Structure, 26, 2018
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6RV0
 | | human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma); with PMP in the active site | | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase | | Authors: | Giardina, G, Cutruzzola, F, Cellini, B, Mirco, D. | | Deposit date: | 2019-05-30 | | Release date: | 2020-04-08 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 1.
Biochem.J., 476, 2019
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6HX7
 | | Crystal structure of human R180T variant of ORNITHINE AMINOTRANSFERASE at 1.8 Angstrom | | Descriptor: | Ornithine aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Giardina, G, Montioli, R, Cellini, B, Cutruzzola, F, Borri Voltattorni, C. | | Deposit date: | 2018-10-16 | | Release date: | 2019-06-05 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | R180T variant of delta-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features.
Febs J., 286, 2019
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3QBR
 | | BakBH3 in complex with sjA | | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Bcl-2 homologous antagonist/killer, SJCHGC06286 protein | | Authors: | Lee, E.F, Clarke, O.B, Fairlie, W.D, Colman, P.M, Evangelista, M, Feng, Z, Speed, T.P, Tchoubrieva, E, Strasser, A, Kalinna, B. | | Deposit date: | 2011-01-13 | | Release date: | 2011-04-13 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proc.Natl.Acad.Sci.USA, 108, 2011
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4P2A
 | | Structure of mouse VPS26A bound to rat SNX27 PDZ domain | | Descriptor: | MERCURY (II) ION, Sorting nexin-27, Vacuolar protein sorting-associated protein 26A | | Authors: | Clairfeuille, T, Gallon, M, Mas, C, Ghai, R, Teasdale, R, Cullen, P, Collins, B. | | Deposit date: | 2014-03-03 | | Release date: | 2014-09-03 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer.
Proc.Natl.Acad.Sci.USA, 111, 2014
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8TXY
 | | X-ray crystal structure of JRD-SIK1/2i-3 bound to a MARK2-SIK2 chimera | | Descriptor: | DI(HYDROXYETHYL)ETHER, N-[(5P,8R)-5-(2-cyano-5-{[(3R)-1-methylpyrrolidin-3-yl]methoxy}pyridin-4-yl)pyrazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide, SULFATE ION, ... | | Authors: | Raymond, D.D, Lemke, C.T, Shaffer, P.L, Collins, B, Steele, R, Seierstad, M. | | Deposit date: | 2023-08-24 | | Release date: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Proc.Natl.Acad.Sci.USA, 121, 2024
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3RBF
 | | Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form | | Descriptor: | Aromatic-L-amino-acid decarboxylase, CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Giardina, G, Montioli, R, Gianni, S, Cellini, B, Paiardini, A, Borri Voltattorni, C, Cutruzzola, F. | | Deposit date: | 2011-03-29 | | Release date: | 2011-10-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3HF5
 | | Crystal structure of 4-methylmuconolactone methylisomerase in complex with 3-methylmuconolactone | | Descriptor: | 4-methylmuconolactone methylisomerase, [(2S)-3-methyl-5-oxo-2,5-dihydrofuran-2-yl]acetic acid | | Authors: | Marin, M, Heinz, D.W, Pieper, D.H, Klink, B.U. | | Deposit date: | 2009-05-11 | | Release date: | 2009-09-29 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal structure and catalytic mechanism of 4-methylmuconolactone methylisomerase
J.Biol.Chem., 284, 2009
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4PQP
 | | Crystal structure of human SNX14 PX domain in space group P43212 | | Descriptor: | GLYCEROL, Sorting nexin-14 | | Authors: | Mas, C, Norwood, S, Bugarcic, A, Kinna, G, Leneva, N, Kovtun, O, Teasdale, R, Collins, B. | | Deposit date: | 2014-03-03 | | Release date: | 2014-09-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Basis for Different Phosphoinositide Specificities of the PX Domains of Sorting Nexins Regulating G-protein Signaling.
J.Biol.Chem., 289, 2014
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1Q4G
 | | 2.0 Angstrom Crystal Structure of Ovine Prostaglandin H2 Synthase-1, in complex with alpha-methyl-4-biphenylacetic acid | | Descriptor: | 2-(1,1'-BIPHENYL-4-YL)PROPANOIC ACID, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | Authors: | Gupta, K, Selinksy, B.S, Kaub, C.J, Katz, A.K, Loll, P.J. | | Deposit date: | 2003-08-03 | | Release date: | 2004-01-06 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The 2.0A Resolution Crystal Structure of Prostaglandin H(2) Synthase-1: Structural Insights into an Unusual Peroxidase
J.Mol.Biol., 335, 2004
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1QIP
 | | HUMAN GLYOXALASE I COMPLEXED WITH S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE | | Descriptor: | BETA-MERCAPTOETHANOL, PROTEIN (LACTOYLGLUTATHIONE LYASE), S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE, ... | | Authors: | Cameron, A.D, Ridderstrom, M, Olin, B, Mannervik, B. | | Deposit date: | 1999-06-14 | | Release date: | 1999-11-24 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
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