4R94
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5GWN
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![BU of 5gwn by Molmil](/molmil-images/mine/5gwn) | Crystal structure of human RCC2 | Descriptor: | Protein RCC2, SULFATE ION | Authors: | Liang, L, Yun, C.H, Yin, Y.X. | Deposit date: | 2016-09-12 | Release date: | 2017-09-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.309 Å) | Cite: | RCC2 is a novel p53 target in suppressing metastasis. Oncogene, 37, 2018
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3F7O
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![BU of 3f7o by Molmil](/molmil-images/mine/3f7o) | Crystal structure of Cuticle-Degrading Protease from Paecilomyces lilacinus (PL646) | Descriptor: | (MSU)(ALA)(ALA)(PRO)(VAL), CALCIUM ION, Serine protease | Authors: | Liang, L, Lou, Z, Meng, Z, Rao, Z, Zhang, K. | Deposit date: | 2008-11-10 | Release date: | 2009-11-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structures of two cuticle-degrading proteases from nematophagous fungi and their contribution to infection against nematodes. Faseb J., 24, 2010
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3F7M
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![BU of 3f7m by Molmil](/molmil-images/mine/3f7m) | Crystal structure of apo Cuticle-Degrading Protease (ver112) from Verticillium psalliotae | Descriptor: | Alkaline serine protease ver112 | Authors: | Liang, L, Lou, Z, Ye, F, Meng, Z, Rao, Z, Zhang, K. | Deposit date: | 2008-11-09 | Release date: | 2009-11-17 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structures of two cuticle-degrading proteases from nematophagous fungi and their contribution to infection against nematodes. Faseb J., 24, 2010
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4RZK
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![BU of 4rzk by Molmil](/molmil-images/mine/4rzk) | Crystal structure of Sulfolobus solfataricus Hsp20.1 ACD | Descriptor: | Small heat shock protein hsp20 family | Authors: | Liang, L, Yun, C.H. | Deposit date: | 2014-12-22 | Release date: | 2015-12-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.677 Å) | Cite: | Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins. Biochem.Biophys.Res.Commun., 2015
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6JOJ
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5XDP
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6JOL
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6KTO
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![BU of 6kto by Molmil](/molmil-images/mine/6kto) | Crystal structure of human SHLD3-C-REV7-O-REV7-SHLD2 complex | Descriptor: | Mitotic spindle assembly checkpoint protein MAD2B, Shieldin complex subunit 2, Shieldin complex subunit 3 | Authors: | Liang, L, Yin, Y. | Deposit date: | 2019-08-28 | Release date: | 2020-04-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.4497633 Å) | Cite: | Molecular basis for assembly of the shieldin complex and its implications for NHEJ. Nat Commun, 11, 2020
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6JOI
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6JOK
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![BU of 6jok by Molmil](/molmil-images/mine/6jok) | Crystal structure of PDGFRA in complex with sunitinib by soaking | Descriptor: | CHLORIDE ION, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, Platelet-derived growth factor receptor alpha | Authors: | Liang, L, Yan, X.E, Yun, C.H. | Deposit date: | 2019-03-22 | Release date: | 2020-03-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Crystal structure of PDGFRA in complex with sunitinib by soaking To Be Published
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7WM2
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![BU of 7wm2 by Molmil](/molmil-images/mine/7wm2) | Cryo-EM structure of AKT1 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium channel AKT1 | Authors: | Dongliang, L, Zijie, Z, Yannan, Q, Yuyue, T, Huaizong, S. | Deposit date: | 2022-01-14 | Release date: | 2023-01-25 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | Structural basis for the regulation mechanism of a hyperpolarization-activated K+ channel AKT1 by AtKC1 To Be Published
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7WM1
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![BU of 7wm1 by Molmil](/molmil-images/mine/7wm1) | Cryo-EM structure of AKT1-AtKC1 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium channel AKT1, ... | Authors: | Dongliang, L, Zijie, Z, Yannan, Q, Yuyue, T, Huaizong, S. | Deposit date: | 2022-01-14 | Release date: | 2023-01-25 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for the regulation mechanism of a hyper polarization-activated K+ channel AKT1 by AtKC1 To Be Published
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2MI7
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![BU of 2mi7 by Molmil](/molmil-images/mine/2mi7) | Solution NMR structure of alpha3Y | Descriptor: | de novo protein a3Y | Authors: | Glover, S.D, Jorge, C, Liang, L, Valentine, K.G, Hammarstrom, L, Tommos, C. | Deposit date: | 2013-12-10 | Release date: | 2014-08-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Photochemical tyrosine oxidation in the structurally well-defined alpha 3Y protein: proton-coupled electron transfer and a long-lived tyrosine radical. J.Am.Chem.Soc., 136, 2014
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5VGT
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![BU of 5vgt by Molmil](/molmil-images/mine/5vgt) | X-ray structure of bacteriophage Sf6 tail adaptor protein gp7 | Descriptor: | CALCIUM ION, Gene 7 protein, MAGNESIUM ION | Authors: | Tang, L, Liang, L, Zhao, H. | Deposit date: | 2017-04-11 | Release date: | 2017-12-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.776 Å) | Cite: | High-resolution structure of podovirus tail adaptor suggests repositioning of an octad motif that mediates the sequential tail assembly. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2LXY
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![BU of 2lxy by Molmil](/molmil-images/mine/2lxy) | NMR structure of 2-MERCAPTOPHENOL-ALPHA3C | Descriptor: | 2-MERCAPTOPHENOL, 2-mercaptophenol-alpha3C | Authors: | Tommos, C, Valentine, K.G, Martinez-Rivera, M.C, Liang, L, Moorman, V.R. | Deposit date: | 2012-09-06 | Release date: | 2013-02-27 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Reversible phenol oxidation and reduction in the structurally well-defined 2-Mercaptophenol-alpha(3)C protein. Biochemistry, 52, 2013
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7MEY
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![BU of 7mey by Molmil](/molmil-images/mine/7mey) | Structure of yeast Ubr1 in complex with Ubc2 and monoubiquitinated N-degron | Descriptor: | 2-(ethylamino)ethane-1-thiol, E3 ubiquitin-protein ligase UBR1, Monoubiquitinated N-degron, ... | Authors: | Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-04-08 | Release date: | 2021-11-24 | Last modified: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 600, 2021
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5K5X
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![BU of 5k5x by Molmil](/molmil-images/mine/5k5x) | Crystal structure of human PDGFRA | Descriptor: | Platelet-derived growth factor receptor alpha, SULFATE ION | Authors: | Yan, X.E, Liang, L, Yun, C.H. | Deposit date: | 2016-05-24 | Release date: | 2016-08-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.168 Å) | Cite: | Structural and biochemical studies of the PDGFRA kinase domain Biochem.Biophys.Res.Commun., 477, 2016
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7MEX
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![BU of 7mex by Molmil](/molmil-images/mine/7mex) | Structure of yeast Ubr1 in complex with Ubc2 and N-degron | Descriptor: | E3 ubiquitin-protein ligase UBR1, N-degron, Ubiquitin, ... | Authors: | Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-04-08 | Release date: | 2021-11-24 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 600, 2021
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8IJ1
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![BU of 8ij1 by Molmil](/molmil-images/mine/8ij1) | Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | Authors: | Dai, Z, Liang, L, Yin, Y.X. | Deposit date: | 2023-02-24 | Release date: | 2024-02-28 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
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8JE2
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![BU of 8je2 by Molmil](/molmil-images/mine/8je2) | Cryo-EM structure of neddylated Cul2-Rbx1-EloBC-FEM1B complexed with FNIP1-FLCN | Descriptor: | Cullin-2, Elongin-B, Elongin-C, ... | Authors: | Dai, Z, Liang, L, Yin, Y.X. | Deposit date: | 2023-05-15 | Release date: | 2024-02-28 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.63 Å) | Cite: | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
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8JE1
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![BU of 8je1 by Molmil](/molmil-images/mine/8je1) | An asymmetry dimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complexed with BEX2 | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | Authors: | Dai, Z, Liang, L, Yin, Y.X. | Deposit date: | 2023-05-15 | Release date: | 2024-02-28 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
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6JBM
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![BU of 6jbm by Molmil](/molmil-images/mine/6jbm) | Crystal structure of the TRIM14 PRYSPRY domain | Descriptor: | SULFATE ION, Tripartite motif-containing protein 14 | Authors: | Yin, Y.X, Yu, Y, Liang, L. | Deposit date: | 2019-01-26 | Release date: | 2020-03-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The TRIM14 PRYSPRY domain mediates protein interaction via its basic interface. Febs Lett., 593, 2019
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6A32
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4MQ1
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![BU of 4mq1 by Molmil](/molmil-images/mine/4mq1) | The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor | Descriptor: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, N-(5-{[(1R)-3-amino-1-(3-chlorophenyl)propyl]carbamoyl}-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, PENTAETHYLENE GLYCOL, ... | Authors: | Lukacs, C.M, Janson, C.A, Garvie, C, Liang, L. | Deposit date: | 2013-09-15 | Release date: | 2013-12-11 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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