4E02
| Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(S)-2-chloro-3-phenylpropanoic acid complex with AMPPNP | 分子名称: | (S)-2-chloro-3-phenylpropanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Tso, S.C, Chuang, J.L, Gui, W.J, Wynn, R.M, Li, J, Chuang, D.T. | 登録日 | 2012-03-02 | 公開日 | 2013-03-13 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1547 Å) | 主引用文献 | Structures of branched-chain alpha-ketoacid dehydrogenase kinase-inhibitor complexes To be Published
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8JR9
| Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha-1, ... | 著者 | Zhao, L, He, Q, Yuan, Q, Gu, Y, He, X, Shan, H, Li, J, Wang, K, Li, Y, Hu, W, Wu, K, Shen, J, Xu, H.E. | 登録日 | 2023-06-16 | 公開日 | 2023-08-02 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | 主引用文献 | Conserved class B GPCR activation by a biased intracellular agonist. Nature, 621, 2023
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4QBO
| VRR_NUC domain | 分子名称: | MAGNESIUM ION, Nuclease | 著者 | Smerdon, S.J, Pennell, S, Li, J. | 登録日 | 2014-05-08 | 公開日 | 2014-09-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain. Cell Rep, 8, 2014
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4E00
| Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with ADP | 分子名称: | 3,6-dichloro-1-benzothiophene-2-carboxylic acid, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Tso, S.C, Chuang, J.L, Gui, W.J, Wynn, R.M, Li, J, Chuang, D.T. | 登録日 | 2012-03-01 | 公開日 | 2013-03-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with ADP To be Published
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4E01
| Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with AMPPNP | 分子名称: | 3,6-dichloro-1-benzothiophene-2-carboxylic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Tso, S.C, Chuang, J.L, Gui, W.J, Wynn, R.M, Li, J, Chuang, D.T. | 登録日 | 2012-03-02 | 公開日 | 2013-03-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structures of branched-chain alpha-ketoacid dehydrogenase kinase-inhibitor complexes To be Published
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2Q8I
| Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol | 分子名称: | DIHYDROLIPOIC ACID, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, GLYCEROL, ... | 著者 | Kato, M, Li, J, Chuang, J.L, Chuang, D.T. | 登録日 | 2007-06-10 | 公開日 | 2007-07-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol. Structure, 15, 2007
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2Q8H
| Structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (DCA) | 分子名称: | DICHLORO-ACETIC ACID, POTASSIUM ION, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1 | 著者 | Kato, M, Li, J, Chuang, J.L, Chuang, D.T. | 登録日 | 2007-06-10 | 公開日 | 2007-07-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol. Structure, 15, 2007
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2Q8G
| Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545 | 分子名称: | 4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE, POTASSIUM ION, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1 | 著者 | Kato, M, Li, J, Chuang, J.L, Chuang, D.T. | 登録日 | 2007-06-10 | 公開日 | 2007-07-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol. Structure, 15, 2007
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4GHQ
| Crystal structure of EV71 3C proteinase | 分子名称: | 3C proteinase | 著者 | Chen, C, Wu, C, Cai, Q, Li, N, Peng, X, Cai, Y, Yin, K, Chen, X, Wang, X, Zhang, R, Liu, L, Chen, S, Li, J, Lin, T. | 登録日 | 2012-08-08 | 公開日 | 2013-06-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir Acta Crystallogr.,Sect.D, 69, 2013
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4JVG
| B-Raf Kinase in Complex with Birb796 | 分子名称: | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, Serine/threonine-protein kinase B-raf | 著者 | Lavoie, H, Thevakumaran, N, Gavory, G, Li, J, Padeganeh, A, Guiral, S, Duchaine, J, Mao, D.Y.L, Bouvier, M, Sicheri, F, Therrien, M. | 登録日 | 2013-03-25 | 公開日 | 2013-05-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nat.Chem.Biol., 9, 2013
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4QBN
| VRR_NUC domain | 分子名称: | Nuclease, SULFATE ION | 著者 | Smerdon, S.J, Pennell, S, Li, J. | 登録日 | 2014-05-08 | 公開日 | 2014-09-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain. Cell Rep, 8, 2014
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4NX2
| Crystal structure of DCYRS complexed with DCY | 分子名称: | 3,5-dichloro-L-tyrosine, Tyrosine--tRNA ligase | 著者 | Wang, J, Gong, W, Li, J, Gao, F, Li, H. | 登録日 | 2013-12-08 | 公開日 | 2014-09-24 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Significant expansion of fluorescent protein sensing ability through the genetic incorporation of superior photo-induced electron-transfer quenchers. J.Am.Chem.Soc., 136, 2014
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2Q8F
| Structure of pyruvate dehydrogenase kinase isoform 1 | 分子名称: | POTASSIUM ION, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1 | 著者 | Kato, M, Li, J, Chuang, J.L, Chuang, D.T. | 登録日 | 2007-06-10 | 公開日 | 2007-07-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol. Structure, 15, 2007
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2QLR
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2QLD
| human Hsp40 Hdj1 | 分子名称: | DnaJ homolog subfamily B member 1 | 著者 | Hu, J, Wu, Y, Li, J, Fu, Z, Sha, B. | 登録日 | 2007-07-12 | 公開日 | 2008-07-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The crystal structure of the putative peptide-binding fragment from the human Hsp40 protein Hdj1. Bmc Struct.Biol., 8, 2008
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2R2N
| The crystal structure of human kynurenine aminotransferase II in complex with kynurenine | 分子名称: | (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ... | 著者 | Han, Q, Robinson, H, Li, J. | 登録日 | 2007-08-27 | 公開日 | 2007-12-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of human kynurenine aminotransferase II. J.Biol.Chem., 283, 2008
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3HLM
| Crystal Structure of Mouse Mitochondrial Aspartate Aminotransferase/Kynurenine Aminotransferase IV | 分子名称: | Aspartate aminotransferase, mitochondrial, GLYCEROL | 著者 | Han, Q, Robinson, H, Li, J. | 登録日 | 2009-05-27 | 公開日 | 2010-06-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. Cell.Mol.Life Sci., 67, 2010
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3E2Y
| Crystal structure of mouse kynurenine aminotransferase III in complex with glutamine | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLUTAMINE, GLYCEROL, ... | 著者 | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | 登録日 | 2008-08-06 | 公開日 | 2008-12-30 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III". Mol. Cell. Biol., 38, 2018
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3E2Z
| Crystal structure of mouse kynurenine aminotransferase III in complex with kynurenine | 分子名称: | (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ... | 著者 | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | 登録日 | 2008-08-06 | 公開日 | 2008-12-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III". Mol. Cell. Biol., 38, 2018
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3QML
| The structural analysis of Sil1-Bip complex reveals the mechanism for Sil1 to function as a novel nucleotide exchange factor | 分子名称: | 78 kDa glucose-regulated protein homolog, MAGNESIUM ION, Nucleotide exchange factor SIL1, ... | 著者 | Yan, M, Li, J.Z, Sha, B.D. | 登録日 | 2011-02-04 | 公開日 | 2011-06-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
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1WUG
| complex structure of PCAF bromodomain with small chemical ligand NP1 | 分子名称: | Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE | 著者 | Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M. | 登録日 | 2004-12-07 | 公開日 | 2005-08-16 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Selective small molecules blocking HIV-1 Tat and coactivator PCAF association J.Am.Chem.Soc., 127, 2005
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1WUM
| Complex structure of PCAF bromodomain with small chemical ligand NP2 | 分子名称: | Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE | 著者 | Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M. | 登録日 | 2004-12-08 | 公開日 | 2005-08-16 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Selective small molecules blocking HIV-1 Tat and coactivator PCAF association J.Am.Chem.Soc., 127, 2005
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5XF7
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3E2F
| Crystal structure of mouse kynurenine aminotransferase III, PLP-bound form | 分子名称: | GLYCEROL, Kynurenine-oxoglutarate transaminase 3 | 著者 | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | 登録日 | 2008-08-05 | 公開日 | 2008-12-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III". Mol. Cell. Biol., 38, 2018
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6A8G
| The crystal structure of muPAin-1-IG in complex with muPA-SPD at pH8.5 | 分子名称: | PHOSPHATE ION, Urokinase-type plasminogen activator chain B, muPAin-1-IG | 著者 | Wang, D, Yang, Y.S, Jiang, L.G, Huang, M.D, Li, J.Y, Andreasen, P.A, Xu, P, Chen, Z. | 登録日 | 2018-07-08 | 公開日 | 2019-02-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides. J.Med.Chem., 62, 2019
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