4E00

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with ADP

Summary for 4E00

• Entry DOI: 10.2210/pdb4e00/pdb
• Related: 3TZ0 3TZ2 3TZ4 3TZ5 4DZY 4E01
• Descriptor: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, 3,6-dichloro-1-benzothiophene-2-carboxylic acid, ... (6 entities in total)
• Functional Keywords: ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Rattus norvegicus (rat)
• Cellular location: Mitochondrion matrix: Q00972
• Total number of polymer chains: 1
• Total formula weight: 48111.95

Authors

Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T. (deposition date: 2012-03-01, release date: 2013-03-27, Last modification date: 2024-02-28)

• Primary citation: Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T.; Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with ADP; To be Published,

Experimental method

X-RAY DIFFRACTION (2.15 Å)