2Q8I

Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol

Summary for 2Q8I

Entry DOI	10.2210/pdb2q8i/pdb
Related	2Q8F 2Q8G 2Q8H
Descriptor	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, POTASSIUM ION, ... (7 entities in total)
Functional Keywords	ghkl atpase/kinase family, pyruvate dehydrogenase complex, mitochondrial kinase, radicicol, transferase
Biological source	Homo sapiens (human) More
Cellular location	Mitochondrion matrix: Q15120 P10515
Total number of polymer chains	2
Total formula weight	63187.39
Authors	Kato, M.,Li, J.,Chuang, J.L.,Chuang, D.T. (deposition date: 2007-06-10, release date: 2007-07-24, Last modification date: 2023-08-30)
Primary citation	Kato, M.,Li, J.,Chuang, J.L.,Chuang, D.T. Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol. Structure, 15:992-1004, 2007 Cited by PubMed: 17683942 DOI: 10.1016/j.str.2007.07.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation