2Q8I
Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3 | polymer | 419 | 48291.0 | 1 | UniProt (Q15120) Pfam (PF10436) Pfam (PF02518) | Homo sapiens (human) | Pyruvate dehydrogenase kinase isoform 3 |
| 2 | B (B) | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex | polymer | 128 | 14192.1 | 1 | UniProt (P10515) Pfam (PF00364) | Homo sapiens (human) | Pyruvate dehydrogenase complex E2 subunit, PDCE2, E2, Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex, PDC-E2, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, PBC, M2 antigen complex 70 kDa subunit |
| 3 | C (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) PubChem (813) | |||
| 4 | D (A) | RADICICOL | non-polymer | 364.8 | 1 | Chemie (RDC) PubChem (5033) PubChem (23304243) PubChem (23351218) PubChem (23375462) PubChem (24871113) PubChem (24883610) PubChem (44323216) PubChem (44634642) PubChem (51535441) PubChem (52224359) PubChem (52224360) PubChem (56846487) PubChem (57685060) PubChem (57729285) PubChem (59114079) PubChem (45933581) PubChem (60028429) PubChem (60043244) PubChem (60046279) PubChem (155901071) PubChem (71684643) PubChem (509980) PubChem (90798921) PubChem (89174685) PubChem (91150137) PubChem (91414470) PubChem (91421888) PubChem (91499444) PubChem (5289273) PubChem (5311380) PubChem (5353918) PubChem (5359013) PubChem (98043729) PubChem (92265824) PubChem (6323491) PubChem (92966529) PubChem (98043730) PubChem (9799192) PubChem (9863893) PubChem (123740891) PubChem (10915493) PubChem (11268547) PubChem (124918602) PubChem (134688667) PubChem (135121972) PubChem (137433107) PubChem (142109646) PubChem (152743492) PubChem (163001975) PubChem (163001976) PubChem (173786049) PubChem (16196977) | |||
| 5 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 6 | F (B) | DIHYDROLIPOIC ACID | non-polymer | 208.3 | 1 | Chemie (RED) PubChem (421) PubChem (449141) PubChem (9834298) | |||
| 7 | G, H (A, B) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A: 9 - 406 (UniProt: Q15120)
B: 126 - 233 (UniProt: P10515)
| PDB | External Database | Details |
|---|---|---|
| Gly -12 | - | cloning artifact |
| Gly -11 | - | cloning artifact |
| Ser -10 | - | cloning artifact |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Gly -3 | - | cloning artifact |
| Met -2 | - | cloning artifact |
| Ala -1 | - | cloning artifact |
| Arg 0 | - | cloning artifact |
| Leu 1 | - | cloning artifact |
| Glu 2 | - | cloning artifact |
| Asn 3 | - | cloning artifact |
| Leu 4 | - | cloning artifact |
| Tyr 5 | - | cloning artifact |
| Phe 6 | - | cloning artifact |
| Gln 7 | - | cloning artifact |
| Gly 8 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Gly 106 | - | cloning artifact |
| Gly 107 | - | cloning artifact |
| Ser 108 | - | cloning artifact |
| His 109 | - | expression tag |
| His 110 | - | expression tag |
| His 111 | - | expression tag |
| His 112 | - | expression tag |
| His 113 | - | expression tag |
| His 114 | - | expression tag |
| Gly 115 | - | cloning artifact |
| Met 116 | - | cloning artifact |
| Ala 117 | - | cloning artifact |
| Arg 118 | - | cloning artifact |
| Leu 119 | - | cloning artifact |
| Glu 120 | - | cloning artifact |
| Asn 121 | - | cloning artifact |
| Leu 122 | - | cloning artifact |
| Tyr 123 | - | cloning artifact |
| Phe 124 | - | cloning artifact |
| Gln 125 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62483.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 704.3 | |
| All* | Total formula weight | 63187.4 |
