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PDB: 666 件
8Z9E
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Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state II
分子名称: Protein structure, RNA (34-MER), RNA (39-MER), ...
著者Zhang, H, Deng, Z, Li, X.
登録日2024-04-23
公開日2024-08-21
最終更新日2024-09-25
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Structural basis for the activity of the type VII CRISPR-Cas system.
Nature, 633, 2024
8Z9C
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BU of 8z9c by Molmil
Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state I
分子名称: Protein structure, RNA (41-MER), RNA (48-MER), ...
著者Zhang, H, Deng, Z, Li, X.
登録日2024-04-23
公開日2024-08-21
最終更新日2024-09-25
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献Structural basis for the activity of the type VII CRISPR-Cas system.
Nature, 633, 2024
8Z99
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Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state +I
分子名称: RNA (49-MER), RNA (54-MER), ZINC ION, ...
著者Zhang, H, Deng, Z, Li, X.
登録日2024-04-22
公開日2024-08-21
最終更新日2024-09-25
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural basis for the activity of the type VII CRISPR-Cas system.
Nature, 633, 2024
8Z4J
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BU of 8z4j by Molmil
Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state II
分子名称: Protein structure, RNA (34-MER), RNA (38-MER), ...
著者Zhang, H, Deng, Z, Li, X.
登録日2024-04-17
公開日2024-08-21
最終更新日2024-09-25
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Structural basis for the activity of the type VII CRISPR-Cas system.
Nature, 633, 2024
6E7P
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cryo-EM structure of human TRPML1 with PI35P2
分子名称: (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], Mucolipin-1
著者Schmiege, P, Li, X.
登録日2018-07-27
公開日2018-11-28
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
6E7Y
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cryo-EM structure of human TRPML1 with PI45P2
分子名称: Mucolipin-1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Schmiege, P, Li, X.
登録日2018-07-27
公開日2018-11-28
実験手法ELECTRON MICROSCOPY (3.57 Å)
主引用文献Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
8IZB
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BU of 8izb by Molmil
Lysophosphatidylserine receptor GPR174-Gs complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Gong, W, Liu, G, Li, X, Zhang, X.
登録日2023-04-06
公開日2023-11-01
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (3.06 Å)
主引用文献Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
Plos Biol., 21, 2023
4I8B
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Crystal Structure of Thioredoxin from Schistosoma Japonicum
分子名称: Thioredoxin
著者Wu, Q, Peng, Y, Zhao, J, Li, X, Fan, X, Zhou, X, Chen, J, Luo, Z, Shi, D.
登録日2012-12-03
公開日2013-12-04
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Expression, characterization and crystal structure of thioredoxin from Schistosoma japonicum.
Parasitology, 142, 2015
6AYF
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TRPML3/ML-SA1 complex at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-3
著者Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J.
登録日2017-09-08
公開日2017-11-08
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
6AYG
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Human Apo-TRPML3 channel at pH 4.8
分子名称: Mucolipin-3
著者Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J.
登録日2017-09-08
公開日2017-11-08
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.65 Å)
主引用文献Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
6AYE
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Human apo-TRPML3 channel at pH 7.4
分子名称: Mucolipin-3
著者Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J.
登録日2017-09-08
公開日2017-11-08
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.06 Å)
主引用文献Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
2VVZ
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Structure of the catalytic domain of Streptococcus pneumoniae sialidase NanA
分子名称: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, CHLORIDE ION, SIALIDASE A
著者Xu, G, Li, X, Andrew, P.W, Taylor, G.L.
登録日2008-06-13
公開日2008-06-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the Catalytic Domain of Streptococcus Pneumoniae Sialidase Nana.
Acta Crystallogr.,Sect.F, 64, 2008
6GQJ
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Crystal structure of human c-KIT kinase domain in complex with AZD3229-analogue (compound 18)
分子名称: 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide, Mast/stem cell growth factor receptor Kit
著者Schimpl, M, Hardy, C.J, Ogg, D.J, Overman, R.C, Packer, M.J, Kettle, J.G, Anjum, R, Barry, E, Bhavsar, D, Brown, C, Campbell, A, Goldberg, K, Grondine, M, Guichard, S, Hunt, T, Jones, O, Li, X, Moleva, O, Pearson, S, Shao, W, Smith, A, Smith, J, Stead, D, Stokes, S, Tucker, M, Ye, Y.
登録日2018-06-07
公開日2018-09-19
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQO
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Crystal structure of human KDR (VEGFR2) kinase domain in complex with AZD3229-analogue (compound 18)
分子名称: 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide, Vascular endothelial growth factor receptor 2
著者Ogg, D.J, Schimpl, M, Hardy, C.J, Overman, R.C, Packer, M.J, Kettle, J.G, Anjum, R, Barry, E, Bhavsar, D, Brown, C, Campbell, A, Goldberg, K, Grondine, M, Guichard, S, Hunt, T, Jones, O, Li, X, Moleva, O, Pearson, S, Shao, W, Smith, A, Smith, J, Stead, D, Stokes, S, Tucker, M, Ye, Y.
登録日2018-06-07
公開日2018-09-19
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQK
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Crystal structure of human c-KIT kinase domain in complex with AZD3229-analogue (compound 23)
分子名称: Mast/stem cell growth factor receptor Kit, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide
著者Schimpl, M, Hardy, C.J, Ogg, D.J, Overman, R.C, Packer, M.J, Kettle, J.G, Anjum, R, Barry, E, Bhavsar, D, Brown, C, Campbell, A, Goldberg, K, Grondine, M, Guichard, S, Hunt, T, Jones, O, Li, X, Moleva, O, Pearson, S, Shao, W, Smith, A, Smith, J, Stead, D, Stokes, S, Tucker, M, Ye, Y.
登録日2018-06-07
公開日2018-09-19
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQM
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Crystal structure of human c-KIT kinase domain in complex with a small molecule inhibitor, AZD3229
分子名称: CHLORIDE ION, Mast/stem cell growth factor receptor Kit, ~{N}-[4-[[5-fluoranyl-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide
著者Schimpl, M, Hardy, C.J, Ogg, D.J, Overman, R.C, Packer, M.J, Kettle, J.G, Anjum, R, Barry, E, Bhavsar, D, Brown, C, Campbell, A, Goldberg, K, Grondine, M, Guichard, S, Hunt, T, Jones, O, Li, X, Moleva, O, Pearson, S, Shao, W, Smith, A, Smith, J, Stead, D, Stokes, S, Tucker, M, Ye, Y.
登録日2018-06-07
公開日2018-09-19
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6E7Z
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cryo-EM structure of human TRPML1 with ML-SA1 and PI35P2
分子名称: (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1
著者Schmiege, P, Li, X.
登録日2018-07-27
公開日2018-11-28
実験手法ELECTRON MICROSCOPY (3.73 Å)
主引用文献Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
6GQP
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Crystal structure of human KDR (VEGFR2) kinase domain in complex with AZD3229-analogue (compound 23)
分子名称: Vascular endothelial growth factor receptor 2, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide
著者Hardy, C.J, Schimpl, M, Ogg, D.J, Overman, R.C, Packer, M.J, Kettle, J.G, Anjum, R, Barry, E, Bhavsar, D, Brown, C, Campbell, A, Goldberg, K, Grondine, M, Guichard, S, Hunt, T, Jones, O, Li, X, Moleva, O, Pearson, S, Shao, W, Smith, A, Smith, J, Stead, D, Stokes, S, Tucker, M, Ye, Y.
登録日2018-06-07
公開日2018-09-19
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQL
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Crystal structure of human c-KIT kinase domain in complex with AZD3229-analogue (compound 35)
分子名称: Mast/stem cell growth factor receptor Kit, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide
著者Schimpl, M, Hardy, C.J, Ogg, D.J, Overman, R.C, Packer, M.J, Kettle, J.G, Anjum, R, Barry, E, Bhavsar, D, Brown, C, Campbell, A, Goldberg, K, Grondine, M, Guichard, S, Hunt, T, Jones, O, Li, X, Moleva, O, Pearson, S, Shao, W, Smith, A, Smith, J, Stead, D, Stokes, S, Tucker, M, Ye, Y.
登録日2018-06-07
公開日2018-09-19
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
2FCG
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Solution structure of the C-terminal fragment of human LL-37
分子名称: Antibacterial protein FALL-39, core peptide
著者Wang, G, Li, X.
登録日2005-12-12
公開日2006-05-23
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution Structures of Human LL-37 Fragments and NMR-Based Identification of a Minimal Membrane-Targeting Antimicrobial and Anticancer Region.
J.Am.Chem.Soc., 128, 2006
2F3A
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Solution structure of the LL-37-derived aurein 1.2 analog (LLAA) in membrane-mimetic micelles
分子名称: aurein 1.2 analog
著者Wang, G, Li, X, Peterkofsky, A.
登録日2005-11-19
公開日2006-10-17
最終更新日2020-06-24
実験手法SOLUTION NMR
主引用文献NMR studies of aurein 1.2 analogs
BIOCHIM.BIOPHYS.ACTA, 1758, 2006
3S5J
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BU of 3s5j by Molmil
2.0A Crystal structure of human phosphoribosyl pyrophosphate synthetase 1
分子名称: Ribose-phosphate pyrophosphokinase 1, SULFATE ION
著者Chen, P, Teng, M, Li, X.
登録日2011-05-23
公開日2012-05-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
2FBU
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Solution structure of the N-terminal fragment of human LL-37
分子名称: Antibacterial protein FALL-39, core peptide
著者Wang, G, Li, X.
登録日2005-12-10
公開日2006-05-23
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution Structures of Human LL-37 Fragments and NMR-Based Identification of a Minimal Membrane-Targeting Antimicrobial and Anticancer Region
J.Am.Chem.Soc., 128, 2006
2FBS
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Solution structure of the LL-37 core peptide bound to detergent micelles
分子名称: Antibacterial protein FALL-39, core peptide
著者Wang, G, Li, X.
登録日2005-12-10
公開日2006-05-23
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Solution Structures of Human LL-37 Fragments and NMR-Based Identification of a Minimal Membrane-Targeting Antimicrobial and Anticancer Region
J.Am.Chem.Soc., 128, 2006
8DKE
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Cryo-EM structure of cystinosin in a cytosol-open state
分子名称: Fab 3H5 Heavy chain, Fab 3H5 Kappa chain, Isoform 2 of Cystinosin
著者Schmiege, P, Li, X.
登録日2022-07-05
公開日2022-09-21
最終更新日2022-10-12
実験手法ELECTRON MICROSCOPY (3.18 Å)
主引用文献Structure and mechanism of human cystine exporter cystinosin.
Cell, 185, 2022

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