8TGN
| VMAT1 dimer with serotonin and reserpine | 分子名称: | Chromaffin granule amine transporter, SEROTONIN, reserpine | 著者 | Ye, J, Liu, B, Li, W. | 登録日 | 2023-07-12 | 公開日 | 2024-03-20 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into vesicular monoamine storage and drug interactions. Nature, 629, 2024
|
|
8TGK
| VMAT1 dimer with histamine and reserpine | 分子名称: | Chromaffin granule amine transporter, HISTAMINE, reserpine | 著者 | Ye, J, Liu, B, Li, W. | 登録日 | 2023-07-12 | 公開日 | 2024-03-20 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into vesicular monoamine storage and drug interactions. Nature, 629, 2024
|
|
2P3V
| Thermotoga maritima IMPase TM1415 | 分子名称: | Inositol-1-monophosphatase, S,R MESO-TARTARIC ACID | 著者 | Stieglitz, K.A, Roberts, M.F, Li, W, Stec, B. | 登録日 | 2007-03-09 | 公開日 | 2007-04-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima. Febs J., 274, 2007
|
|
6KTR
| Crystal structure of fibroblast growth factor 19 in complex with Fab | 分子名称: | Fibroblast growth factor 19, G1A8-Fab-HC, G1A8-Fab-LC, ... | 著者 | Liu, H, Zheng, S, Hou, X, Liu, X, Lv, X, Li, Y, Li, W, Sui, J. | 登録日 | 2019-08-28 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.59775758 Å) | 主引用文献 | Novel Abs targeting the N-terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile-acid-related side-effects. Cancer Sci., 111, 2020
|
|
5TIG
| |
3L9Y
| Crystal structures of holo and Cu-deficient Cu/ZnSOD from the silkworm Bombyx mori and the implications in Amyotrophic lateral sclerosis | 分子名称: | COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION | 著者 | Zhang, N.-N, He, Y.-X, Li, W.-F, Zhao, F, Yan, L.-F, Zhang, G.-Z, Teng, Y.-B, Yu, J, Chen, Y, Zhou, C.-Z. | 登録日 | 2010-01-06 | 公開日 | 2010-03-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structures of holo and Cu-deficient Cu/Zn-SOD from the silkworm Bombyx mori and the implications in amyotrophic lateral sclerosis. Proteins, 78, 2010
|
|
5H7O
| Crystal structure of DJ-101 in complex with tubulin protein | 分子名称: | 2-(1H-indol-4-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Arnst, K, Wang, Y, Hwang, D.-J, Xue, Y, Costello, T, Hamilton, D, Chen, Q, Yang, J, Park, F, Dalton, J.T, Miller, D.D, Li, W. | 登録日 | 2016-11-20 | 公開日 | 2017-12-13 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance. Cancer Res., 78, 2018
|
|
4LAK
| Crystal structure of Cordyceps militaris IDCase D323N mutant in apo form | 分子名称: | Uracil-5-carboxylate decarboxylase, ZINC ION | 著者 | Xu, S, Li, W, Zhu, J, Wang, R, Li, Z, Xu, G.L, Ding, J. | 登録日 | 2013-06-20 | 公開日 | 2013-10-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res., 23, 2013
|
|
6O9K
| 70S initiation complex | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Frank, J, Gonzalez Jr, R.L, kaledhonkar, S, Fu, Z, Caban, K, Li, W, Chen, B, Sun, M. | 登録日 | 2019-03-14 | 公開日 | 2019-05-29 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Late steps in bacterial translation initiation visualized using time-resolved cryo-EM. Nature, 570, 2019
|
|
6O9J
| 70S Elongation Competent Ribosome | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Frank, J, Gonzalez Jr, R.L, Kaledhonkar, S, Fu, Z, Caban, K, Li, W, Chen, B, Sun, M. | 登録日 | 2019-03-14 | 公開日 | 2019-05-29 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Late steps in bacterial translation initiation visualized using time-resolved cryo-EM. Nature, 570, 2019
|
|
8JHG
| Native SUV420H1 bound to 167-bp nucleosome | 分子名称: | DNA (160-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | 著者 | Lin, F, Li, W. | 登録日 | 2023-05-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase. Cell Discov, 9, 2023
|
|
8JHF
| Native SUV420H1 bound to 167-bp nucleosome | 分子名称: | DNA (160-MER), Histone H2A.Z, Histone H2B type 1-K, ... | 著者 | Lin, F, Li, W. | 登録日 | 2023-05-23 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase. Cell Discov, 9, 2023
|
|
1QZC
| Coordinates of S12, SH44, LH69 and SRL separately fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S12 | 著者 | Valle, M, Zavialov, A, Li, W, Stagg, S.M, Sengupta, J, Nielsen, R.C, Nissen, P, Harvey, S.C, Ehrenberg, M, Frank, J. | 登録日 | 2003-09-16 | 公開日 | 2003-11-04 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (9 Å) | 主引用文献 | Incorporation of Aminoacyl-tRNA into the Ribosome as seen by Cryo-electron Microscopy Nat.Struct.Biol., 10, 2003
|
|
1QZD
| EF-Tu.kirromycin coordinates fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome | 分子名称: | Elongation factor Tu | 著者 | Valle, M, Zavialov, A, Li, W, Stagg, S.M, Sengupta, J, Nielsen, R.C, Nissen, P, Harvey, S.C, Ehrenberg, M, Frank, J. | 登録日 | 2003-09-16 | 公開日 | 2003-11-04 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (10 Å) | 主引用文献 | Incorporation of Aminoacyl-tRNA into the Ribosome as seen by Cryo-electron Microscopy Nat.Struct.Biol., 10, 2003
|
|
1QZB
| Coordinates of the A-site tRNA model fitted into the cryo-EM map of 70S ribosome in the pre-translocational state | 分子名称: | Phe-tRNA | 著者 | Valle, M, Zavialov, A, Li, W, Stagg, S.M, Sengupta, J, Nielsen, R.C, Nissen, P, Harvey, S.C, Ehrenberg, M, Frank, J. | 登録日 | 2003-09-16 | 公開日 | 2003-11-04 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (9 Å) | 主引用文献 | Incorporation of Aminoacyl-tRNA into the Ribosome as seen by Cryo-electron Microscopy Nat.Struct.Biol., 10, 2003
|
|
1QZA
| Coordinates of the A/T site tRNA model fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome | 分子名称: | Phe-tRNA | 著者 | Valle, M, Zavialov, A, Li, W, Stagg, S.M, Sengupta, J, Nielsen, R.C, Nissen, P, Harvey, S.C, Ehrenberg, M, Frank, J. | 登録日 | 2003-09-16 | 公開日 | 2003-11-04 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (10 Å) | 主引用文献 | Incorporation of Aminoacyl-tRNA into the Ribosome as seen by Cryo-electron Microscopy Nat.Struct.Biol., 10, 2003
|
|
1R2X
| Coordinates of L11 with 58nts of 23S rRNA fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome | 分子名称: | 50S ribosomal protein L11, 58nts of 23S rRNA | 著者 | Valle, M, Zavialov, A, Li, W, Stagg, S.M, Sengupta, J, Nielsen, R.C, Nissen, P, Harvey, S.C, Ehrenberg, M, Frank, J. | 登録日 | 2003-09-30 | 公開日 | 2003-11-04 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (9 Å) | 主引用文献 | Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron Microscopy Nat.Struct.Biol., 10, 2003
|
|
2GM4
| An activated, tetrameric gamma-delta resolvase: Hin chimaera bound to cleaved DNA | 分子名称: | 5'-D(*CP*AP*GP*TP*GP*TP*CP*CP*GP*AP*TP*AP*AP*TP*TP*TP*AP*TP*AP*AP*A)-3', 5'-D(*TP*TP*AP*TP*CP*GP*GP*AP*CP*AP*CP*TP*G)-3', Transposon gamma-delta resolvase | 著者 | Kamtekar, S, Ho, R.S, Li, W, Steitz, T.A. | 登録日 | 2006-04-05 | 公開日 | 2006-06-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination. Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
2GM5
| An activated, truncated gamma-delta resolvase tetramer | 分子名称: | Transposon gamma-delta resolvase | 著者 | Kamtekar, S, Ho, R.S, Li, W, Steitz, T.A. | 登録日 | 2006-04-05 | 公開日 | 2006-06-27 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination. Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
5Y2V
| Strcutrue of the full-length CcmR complexed with 2-OG from Synechocystis PCC6803 | 分子名称: | 2-OXOGLUTARIC ACID, PHOSPHATE ION, Rubisco operon transcriptional regulator | 著者 | Jiang, Y.L, Wang, X.P, Sun, H, Cheng, W, Han, S.J, Li, W.F, Chen, Y, Zhou, C.Z. | 登録日 | 2017-07-27 | 公開日 | 2017-12-27 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
5Y2W
| Structure of Synechocystis PCC6803 CcmR regulatory domain in complex with 2-PG | 分子名称: | 2-PHOSPHOGLYCOLIC ACID, Rubisco operon transcriptional regulator | 著者 | Jiang, Y.L, Wang, X.P, Sun, H, Cheng, W, Cao, D.D, Han, S.J, Li, W.F, Chen, Y, Zhou, C.Z. | 登録日 | 2017-07-27 | 公開日 | 2017-12-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
4LAO
| Crystal structure of Cordyceps militaris IDCase H195A mutant (Zn) | 分子名称: | Cordyceps militaris IDCase, DI(HYDROXYETHYL)ETHER, ZINC ION | 著者 | Xu, S, Li, W, Zhu, J, Ding, J. | 登録日 | 2013-06-20 | 公開日 | 2013-10-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res., 23, 2013
|
|
4LAN
| Crystal structure of Cordyceps militaris IDCase H195A mutant | 分子名称: | Uracil-5-carboxylate decarboxylase, ZINC ION | 著者 | Xu, S, Li, W, Zhu, J, Ding, J. | 登録日 | 2013-06-20 | 公開日 | 2013-10-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res., 23, 2013
|
|
5YL4
| CRYSTAL STRUCTURE OF T2R-TTL-8WR COMPLEX | 分子名称: | (3Z,6Z)-3-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]-6-[[3-(phenylcarbonyl)phenyl]methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Fu, Z.Y, Li, W.B, Chu, Y.Y, Hou, Y.W, Ji, C.P. | 登録日 | 2017-10-17 | 公開日 | 2017-11-15 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Design, synthesis and biological activity evaluation of plinabulin derivatives based on co-crystal structure To Be Published
|
|
4LAM
| Crystal structure of Cordyceps militaris IDCase D323N mutant in complex with 5-carboxyl-uracil | 分子名称: | 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, HEXAETHYLENE GLYCOL, Uracil-5-carboxylate decarboxylase, ... | 著者 | Xu, S, Li, W, Zhu, J, Ding, J. | 登録日 | 2013-06-20 | 公開日 | 2013-10-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res., 23, 2013
|
|