5YL4

CRYSTAL STRUCTURE OF T2R-TTL-8WR COMPLEX

Summary for 5YL4

• Entry DOI: 10.2210/pdb5yl4/pdb
• Related: 5XHC 5XI5 5XI7
• Descriptor: Tubulin alpha chain, (3Z,6Z)-3-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]-6-[[3-(phenylcarbonyl)phenyl]methylidene]piperazine-2,5-dione, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: tubulin, microtubule, colchicine, diketopiperazine, structural protein
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton : A0A0R4I993 A0A0R4I995; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 264871.35

Authors

Fu, Z.Y.,Li, W.B.,Chu, Y.Y.,Hou, Y.W.,Ji, C.P. (deposition date: 2017-10-17, release date: 2017-11-15, Last modification date: 2024-03-27)

• Primary citation: Fu, Z.Y.,Li, W.B.; Design, synthesis and biological activity evaluation of plinabulin derivatives based on co-crystal structure; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.64 Å)