5X1R
| PpkA-294 apo form | Descriptor: | PpkA-294 | Authors: | Li, P.P, Ran, T.T, Xu, D.Q, Wang, W.W. | Deposit date: | 2017-01-26 | Release date: | 2018-01-31 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism. Biochem.J., 475, 2018
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7JFL
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5WSO
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4LEZ
| Structure of mouse cGAS bound to an 18bp DNA and cGAS product | Descriptor: | 18bp dsDNA, Cyclic GMP-AMP synthase, ZINC ION, ... | Authors: | Li, P. | Deposit date: | 2013-06-26 | Release date: | 2013-12-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization. Immunity, 39, 2013
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4LEY
| Structure of mouse cGAS bound to 18 bp DNA | Descriptor: | 18 bp dsDNA, Cyclic GMP-AMP synthase, ZINC ION | Authors: | Li, P. | Deposit date: | 2013-06-26 | Release date: | 2013-12-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization. Immunity, 39, 2013
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1HYR
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3GA3
| Crystal structure of the C-terminal domain of human MDA5 | Descriptor: | Interferon-induced helicase C domain-containing protein 1, MDA5, ZINC ION | Authors: | Li, P. | Deposit date: | 2009-02-16 | Release date: | 2009-02-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal structure of the C-terminal domain of human MDA5 To be Published
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1N1A
| Crystal Structure of the N-terminal domain of human FKBP52 | Descriptor: | FKBP52 | Authors: | Li, P, Ding, Y, Wu, B, Shu, C, Shen, B, Rao, Z. | Deposit date: | 2002-10-16 | Release date: | 2002-12-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the N-terminal domain of human FKBP52. Acta Crystallogr.,Sect.D, 59, 2003
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2OTU
| Crystal structure of Fv polyglutamine complex | Descriptor: | Fv heavy chain variable domain, Fv light chain variable domain, peptide antigen | Authors: | Li, P. | Deposit date: | 2007-02-09 | Release date: | 2007-04-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Implications of the structure of a poly-Gln/anti-poly-Gln complex for disease progression and therapy To be Published
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6LKA
| Crystal Structure of EV71-3C protease with a Novel Macrocyclic Compounds | Descriptor: | 3C proteinase, ~{N}-[(2~{S})-1-[[(2~{S},3~{S},6~{S},7~{Z},12~{E})-4,9-bis(oxidanylidene)-6-[[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]methyl]-2-phenyl-1,10-dioxa-5-azacyclopentadeca-7,12-dien-3-yl]amino]-3-methyl-1-oxidanylidene-butan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide | Authors: | Li, P, Wu, S.Q, Xiao, T.Y.C, Li, Y.L, Su, Z.M, Hao, F, Hu, G.P, Hu, J, Lin, F.S, Chen, X.S, Gu, Z.X, He, H.Y, Li, J, Chen, S.H. | Deposit date: | 2019-12-18 | Release date: | 2020-06-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.033 Å) | Cite: | Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent. Bioorg.Med.Chem., 28, 2020
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5JEJ
| Phosphorylated STING in complex with IRF-3 CTD | Descriptor: | Interferon regulatory factor 3, Stimulator of interferon genes protein | Authors: | Li, P, Shu, C. | Deposit date: | 2016-04-18 | Release date: | 2016-06-15 | Last modified: | 2016-06-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc.Natl.Acad.Sci.USA, 113, 2016
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1JFM
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4LEW
| Structure of human cGAS | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | Authors: | Li, P. | Deposit date: | 2013-06-26 | Release date: | 2013-12-25 | Last modified: | 2014-01-08 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization. Immunity, 39, 2013
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2OTW
| Crystal structure of Fv polyglutamine complex | Descriptor: | Fv heavy chain variable domain VH, Fv light chain avriable domain VL, poly-Gln peptide antigen | Authors: | Li, P. | Deposit date: | 2007-02-09 | Release date: | 2007-04-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Implications of the structure of a poly-Gln/anti-poly-Gln complex for disease progression and therapy To be Published
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3LRR
| Crystal structure of human RIG-I CTD bound to a 12 bp AU rich 5' ppp dsRNA | Descriptor: | Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(*(ATP)P*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*U)-3'), ZINC ION | Authors: | Li, P. | Deposit date: | 2010-02-11 | Release date: | 2010-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The Structural Basis of 5' Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain. Structure, 18, 2010
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3OG8
| Crystal structure of human RIG-I CTD bound to a 14-bp blunt-ended dsRNA | Descriptor: | Antiviral innate immune response receptor RIG-I, RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3'), ZINC ION | Authors: | Li, P. | Deposit date: | 2010-08-16 | Release date: | 2010-11-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate. Nucleic Acids Res., 39, 2011
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7EOD
| MITF HLHLZ Delta AKE | Descriptor: | GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor | Authors: | Li, P, Liu, Z, Fang, P, Wang, J. | Deposit date: | 2021-04-22 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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4LEV
| Structure of human cGAS | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | Authors: | Li, P. | Deposit date: | 2013-06-26 | Release date: | 2013-12-25 | Last modified: | 2014-01-08 | Method: | X-RAY DIFFRACTION (1.952 Å) | Cite: | Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization. Immunity, 39, 2013
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3E3H
| Crystal structure of the OP hydrolase mutant from Brevundimonas diminuta | Descriptor: | COBALT (II) ION, DIETHYL 4-METHYLBENZYLPHOSPHONATE, Parathion hydrolase | Authors: | Li, P, Reeves, T.E, Grimsley, J.K, Wild, J.R. | Deposit date: | 2008-08-07 | Release date: | 2008-10-07 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities. Protein Eng.Des.Sel., 21, 2008
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1B3J
| STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MHC CLASS I HOMOLOG MIC-A | Authors: | Li, P, Willie, S, Bauer, S, Morris, D, Spies, T, Strong, R. | Deposit date: | 1998-12-11 | Release date: | 1999-07-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand. Immunity, 10, 1999
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4PP8
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3S2X
| Structure of acetyl-Coenzyme A synthase Alpha subunit C-terminal domain | Descriptor: | NICKEL (II) ION, acetyl-CoA synthase subunit alpha | Authors: | Li, P. | Deposit date: | 2011-05-17 | Release date: | 2011-07-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Insights into the Mechanistic Role of the [Fe(4) S(4) ] Cubane in the A-Cluster {[Fe(4) S(4) ]-(SR)-[Ni(p) Ni(d) ]} of Acetyl-Coenzyme A Synthase. Chembiochem, 12, 2011
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3U9M
| Structure of reduced human FBXL5 hemerythrin like domain | Descriptor: | F-box/LRR-repeat protein 5, FE (III) ION | Authors: | Li, P. | Deposit date: | 2011-10-19 | Release date: | 2012-02-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The Structural Basis of Iron Sensing by the Human F-box Protein FBXL5. Chembiochem, 13, 2012
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5V5F
| Crystal structure of RICE1 (PNT2) | Descriptor: | At3g11770 | Authors: | Li, P. | Deposit date: | 2017-03-14 | Release date: | 2017-09-13 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.945 Å) | Cite: | RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana. Elife, 6, 2017
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4JLC
| Crystal structure of mouse TBK1 bound to SU6668 | Descriptor: | 3-{2,4-dimethyl-5-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid, Serine/threonine-protein kinase TBK1 | Authors: | Li, P. | Deposit date: | 2013-03-12 | Release date: | 2013-06-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity. Structure, 21, 2013
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