5D9Y
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![BU of 5d9y by Molmil](/molmil-images/mine/5d9y) | Crystal structure of TET2-5fC complex | Descriptor: | DNA (5'-D(*AP*CP*TP*GP*TP*(5FC)P*GP*AP*AP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*TP*TP*CP*GP*AP*CP*AP*GP*T)-3'), FE (III) ION, ... | Authors: | Hu, L, Cheng, J, Rao, Q, Li, Z, Li, J, Xu, Y. | Deposit date: | 2015-08-19 | Release date: | 2015-11-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.971 Å) | Cite: | Structural insight into substrate preference for TET-mediated oxidation. Nature, 527, 2015
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5GZO
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![BU of 5gzo by Molmil](/molmil-images/mine/5gzo) | Structure of neutralizing antibody bound to Zika envelope protein | Descriptor: | Antibody heavy chain, Antibody light chain, Genome polyprotein | Authors: | Wang, Q, Yang, H, Liu, X, Dai, L, Ma, T, Qi, J, Wong, G, Peng, R, Liu, S, Li, J, Li, S, Song, J, Liu, J, He, J, Yuan, H, Xiong, Y, Liao, Y, Li, J, Yang, J, Tong, Z, Griffin, B, Bi, Y, Liang, M, Xu, X, Cheng, G, Wang, P, Qiu, X, Kobinger, G, Shi, Y, Yan, J, Gao, G.F. | Deposit date: | 2016-09-29 | Release date: | 2017-01-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.755 Å) | Cite: | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
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5DEU
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![BU of 5deu by Molmil](/molmil-images/mine/5deu) | Crystal structure of TET2-5hmC complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, DNA (5'-D(*AP*CP*CP*AP*CP*(5HC)P*GP*GP*TP*GP*GP*T)-3'), ... | Authors: | Hu, L, Cheng, J, Rao, Q, Li, Z, Li, J, Xu, Y. | Deposit date: | 2015-08-26 | Release date: | 2015-11-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Structural insight into substrate preference for TET-mediated oxidation. Nature, 527, 2015
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6LAR
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![BU of 6lar by Molmil](/molmil-images/mine/6lar) | Structure of ESX-3 complex | Descriptor: | ESX-3 secretion system ATPase EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... | Authors: | Wang, S.H, Zhou, K.X, Li, J, Rao, Z.H. | Deposit date: | 2019-11-13 | Release date: | 2020-11-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | cryo-em structure of esx-3 To Be Published
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5C1Y
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![BU of 5c1y by Molmil](/molmil-images/mine/5c1y) | Crystal structure of EV71 3C Proteinase in complex with Compound 1 | Descriptor: | 3C proteinase, propan-2-yl N-[(2S)-1-oxidanylidene-1-[[(2S)-1-oxidanyl-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-3-phenyl-propan-2-yl]carbamate | Authors: | Zhang, L, Huang, G, Cai, Q, Zhao, C, Ren, H, Li, P, Li, N, Chen, S, Li, J, Lin, T. | Deposit date: | 2015-06-15 | Release date: | 2016-06-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71 J.Mol.Recognit., 29, 2016
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5C20
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![BU of 5c20 by Molmil](/molmil-images/mine/5c20) | Crystal structure of EV71 3C Proteinase in complex with Compound 2 | Descriptor: | 2-methylpropyl N-[(2S)-1-oxidanylidene-1-[[(2S)-1-oxidanyl-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-3-phenyl-propan-2-yl]carbamate, 3C proteinase | Authors: | Zhang, L, Huang, G, Cai, Q, Zhao, C, Ren, H, Li, P, Li, N, Chen, S, Li, J, Lin, T. | Deposit date: | 2015-06-15 | Release date: | 2016-06-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71 J.Mol.Recognit., 29, 2016
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5C1U
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![BU of 5c1u by Molmil](/molmil-images/mine/5c1u) | Crystal structure of EV71 3C Proteinase in complex with Compound Xb | Descriptor: | (2S)-2-[[(E)-3-[4-(dimethylamino)phenyl]prop-2-enoyl]amino]-N-[(2S)-1-oxidanyl-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3-phenyl-propanamide, 3C proteinase | Authors: | Zhang, L, Huang, G, Cai, Q, Zhao, C, Ren, H, Li, P, Li, N, Chen, S, Li, J, Lin, T. | Deposit date: | 2015-06-15 | Release date: | 2016-06-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71 J.Mol.Recognit., 29, 2016
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5C1X
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![BU of 5c1x by Molmil](/molmil-images/mine/5c1x) | Crystal structure of EV71 3C Proteinase in complex with Compound VIII | Descriptor: | (phenylmethyl) N-[(2S)-1-oxidanylidene-1-[[(2S)-1-oxidanyl-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-3-phenyl-propan-2-yl]carbamate, 3C proteinase | Authors: | Zhang, L, Huang, G, Cai, Q, Zhao, C, Ren, H, Li, P, Li, N, Chen, S, Li, J, Lin, T. | Deposit date: | 2015-06-15 | Release date: | 2016-06-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71 J.Mol.Recognit., 29, 2016
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4Y07
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![BU of 4y07 by Molmil](/molmil-images/mine/4y07) | Crystal structure of the HECT domain of human WWP2 | Descriptor: | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Authors: | Gong, W, Li, J, Li, Z, Xu, Y. | Deposit date: | 2015-02-05 | Release date: | 2015-11-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.507 Å) | Cite: | Structure of the HECT domain of human WWP2 Acta Crystallogr.,Sect.F, 71, 2015
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1W7M
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![BU of 1w7m by Molmil](/molmil-images/mine/1w7m) | Crystal structure of human kynurenine aminotransferase I in complex with L-Phe | Descriptor: | KYNURENINE--OXOGLUTARATE TRANSAMINASE I, PHENYLALANINE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Rossi, F, Han, Q, Li, J, Li, J, Rizzi, M. | Deposit date: | 2004-09-06 | Release date: | 2004-09-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structure of Human Kynurenine Aminotransferase I J.Biol.Chem., 279, 2004
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5JI8
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![BU of 5ji8 by Molmil](/molmil-images/mine/5ji8) | Crystal structure of the BRD9 bromodomain and hit 1 | Descriptor: | 2-amino-1,3-benzothiazole-6-carboxamide, Bromodomain-containing protein 9 | Authors: | Wang, N, Li, F, Bao, H, Li, J, Wu, J, Ruan, K. | Deposit date: | 2016-04-22 | Release date: | 2016-06-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | NMR Fragment Screening Hit Induces Plasticity of BRD7/9 Bromodomains Chembiochem, 17, 2016
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8Y37
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![BU of 8y37 by Molmil](/molmil-images/mine/8y37) | Cryo-EM structure of Staphylococcus aureus (15B196) 50S ribosome in complex with MCX-190. | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, 7-[4-[3-[[(1~{S},2~{R},5~{R},6~{S},7~{S},8~{R},9~{R},11~{R},13~{R},14~{R})-8-[(2~{S},3~{R},4~{S},6~{R})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid, ... | Authors: | Li, Y, Lu, G, Li, J, Pei, X, Lin, J. | Deposit date: | 2024-01-28 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | Synthetic macrolides overcoming MLS B K-resistant pathogens. Cell Discov, 10, 2024
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9J23
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![BU of 9j23 by Molmil](/molmil-images/mine/9j23) | Structure of a triple-helix region of human Collagen type II from Trautec | Descriptor: | Triple-helix region of human collagen type II | Authors: | Fan, X, Zhai, Y, Chu, Y, Fu, S, Li, D, Feng, P, Cao, K, Li, J, Si, Y, Ma, L, Qian, S. | Deposit date: | 2024-08-06 | Release date: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of a triple-helix region of human Collagen type II from Trautec To Be Published
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8Y39
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![BU of 8y39 by Molmil](/molmil-images/mine/8y39) | cryo-EM structure of Staphylococcus aureus(ATCC 29213) 70S ribosome in complex with MCX-190. | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Li, Y, Lu, G, Li, J, Pei, X, Lin, J. | Deposit date: | 2024-01-28 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Synthetic macrolides overcoming MLS B K-resistant pathogens. Cell Discov, 10, 2024
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8Y36
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![BU of 8y36 by Molmil](/molmil-images/mine/8y36) | cryo-EM structure of Staphylococcus aureus(ATCC 29213) 50S ribosome in complex with MCX-190. | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, 7-[4-[3-[[(1~{S},2~{R},5~{R},6~{S},7~{S},8~{R},9~{R},11~{R},13~{R},14~{R})-8-[(2~{S},3~{R},4~{S},6~{R})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid, ... | Authors: | Li, Y, Lu, G, Li, J, Pei, X, Lin, J. | Deposit date: | 2024-01-28 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Synthetic macrolides overcoming MLS B K-resistant pathogens. Cell Discov, 10, 2024
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8Y38
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![BU of 8y38 by Molmil](/molmil-images/mine/8y38) | Cryo-EM structure of Staphylococcus aureus 70S ribosome (strain 15B196) in complex with MCX-190. | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Li, Y, Lu, G, Li, J, Pei, X, Lin, J. | Deposit date: | 2024-01-28 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Synthetic macrolides overcoming MLS B K-resistant pathogens. Cell Discov, 10, 2024
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7CBY
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![BU of 7cby by Molmil](/molmil-images/mine/7cby) | Structure of FOXG1 DNA binding domain bound to DBE2 DNA site | Descriptor: | DI(HYDROXYETHYL)ETHER, DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), ... | Authors: | Dai, S.Y, Li, J, Chen, Y.H. | Deposit date: | 2020-06-15 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.646 Å) | Cite: | Structural Basis for DNA Recognition by FOXG1 and the Characterization of Disease-causing FOXG1 Mutations. J.Mol.Biol., 432, 2020
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4HJR
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![BU of 4hjr by Molmil](/molmil-images/mine/4hjr) | Crystal structure of F2YRS | Descriptor: | Tyrosine-tRNA ligase | Authors: | Wang, J, Tian, C, Gong, W, Li, F, Shi, P, Li, J, Ding, W. | Deposit date: | 2012-10-13 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A genetically encoded 19F NMR probe for tyrosine phosphorylation. Angew.Chem.Int.Ed.Engl., 52, 2013
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4HJX
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![BU of 4hjx by Molmil](/molmil-images/mine/4hjx) | Crystal structure of F2YRS complexed with F2Y | Descriptor: | 3,5-difluoro-L-tyrosine, Tyrosine-tRNA ligase | Authors: | Wang, J, Tian, C, Gong, W, Li, F, Shi, P, Li, J, Ding, W. | Deposit date: | 2012-10-14 | Release date: | 2013-03-13 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | A genetically encoded 19F NMR probe for tyrosine phosphorylation. Angew.Chem.Int.Ed.Engl., 52, 2013
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1BWQ
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![BU of 1bwq by Molmil](/molmil-images/mine/1bwq) | PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | Descriptor: | PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | Authors: | Ho, Y.S, Sheffield, P.J, Masuyama, J, Arai, H, Li, J, Aoki, J, Inoue, K, Derewenda, U, Derewenda, Z. | Deposit date: | 1998-09-27 | Release date: | 1999-05-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Probing the Substrate Specificity of the Intracellular Brain Platelet-Activating Factor Acetylhydrolase Protein Eng., 12, 1999
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1BWR
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![BU of 1bwr by Molmil](/molmil-images/mine/1bwr) | PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | Descriptor: | PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | Authors: | Ho, Y.S, Sheffield, P.J, Masuyama, J, Arai, H, Li, J, Aoki, J, Inoue, K, Derewenda, U, Derewenda, Z. | Deposit date: | 1998-09-27 | Release date: | 1999-05-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Probing the Substrate Specificity of the Intracellular Brain Platelet-Activating Factor Acetylhydrolase Protein Eng., 12, 1999
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1BWP
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![BU of 1bwp by Molmil](/molmil-images/mine/1bwp) | PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | Descriptor: | PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE | Authors: | Ho, Y.S, Sheffield, P.J, Masuyama, J, Arai, H, Li, J, Aoki, J, Inoue, K, Derewenda, U, Derewenda, Z. | Deposit date: | 1998-09-27 | Release date: | 1999-05-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Probing the Substrate Specificity of the Intracellular Brain Platelet-Activating Factor Acetylhydrolase Protein Eng., 12, 1999
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3DEJ
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![BU of 3dej by Molmil](/molmil-images/mine/3dej) | Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors | Descriptor: | (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3 | Authors: | Wu, J, Du, J, Li, J, Ding, J. | Deposit date: | 2008-06-10 | Release date: | 2008-09-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
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3DEH
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![BU of 3deh by Molmil](/molmil-images/mine/3deh) | Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors | Descriptor: | Caspase-3, isoquinoline-1,3,4(2H)-trione | Authors: | Wu, J, Du, J, Li, J, Ding, J. | Deposit date: | 2008-06-10 | Release date: | 2008-09-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
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3DEI
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![BU of 3dei by Molmil](/molmil-images/mine/3dei) | Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors | Descriptor: | (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3 | Authors: | Wu, J, Du, J, Li, J, Ding, J. | Deposit date: | 2008-06-10 | Release date: | 2008-09-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
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