6GCR
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![BU of 6gcr by Molmil](/molmil-images/mine/6gcr) | Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor | 分子名称: | 2-[[2-[[4-[[[3,4-bis(oxidanylidene)-2-[2-(propanoylamino)ethylamino]cyclobuten-1-yl]amino]methyl]phenyl]amino]-5-chloranyl-pyrimidin-4-yl]amino]-~{N}-methyl-benzamide, Focal adhesion kinase 1 | 著者 | Yen-Pon, E, Li, B, Acebron-Garcia de Eulate, M, Tomkiewicz-Raulet, C, Dawson, J, Lietha, D, Frame, M.C, Coumoul, X, Garbay, C, Etheve-Quelquejeu, M, Chen, H. | 登録日 | 2018-04-19 | 公開日 | 2019-05-01 | 最終更新日 | 2019-10-02 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase. Acs Chem.Biol., 13, 2018
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5VIF
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![BU of 5vif by Molmil](/molmil-images/mine/5vif) | Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase | 分子名称: | 2-{[(2E)-4-chlorobut-2-enoyl]amino}-2-deoxy-beta-D-glucopyranose, CKII, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, ... | 著者 | Jiang, J, Li, B, Hu, C.-W, Worth, M, Fan, D, Li, H. | 登録日 | 2017-04-15 | 公開日 | 2017-10-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase. Nat. Chem. Biol., 13, 2017
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3DL7
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![BU of 3dl7 by Molmil](/molmil-images/mine/3dl7) | Aged Form of Mouse Acetylcholinesterase Inhibited by Tabun- Update | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, CHLORIDE ION, ... | 著者 | Carletti, E, Li, H, Li, B, Ekstrom, F, Nicolet, Y, Loiodice, M, Gillon, E, Froment, M.T, Lockridge, O, Schopfer, L.M, Masson, P, Nachon, F. | 登録日 | 2008-06-26 | 公開日 | 2008-12-02 | 最終更新日 | 2021-03-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation. J.Am.Chem.Soc., 130, 2008
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3PFT
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![BU of 3pft by Molmil](/molmil-images/mine/3pft) | Crystal Structure of Untagged C54A Mutant Flavin Reductase (DszD) in Complex with FMN From Mycobacterium goodii | 分子名称: | FLAVIN MONONUCLEOTIDE, Flavin reductase | 著者 | Li, Q, Xu, P, Ma, C, Gu, L, Liu, X, Zhang, C, Li, N, Su, J, Li, B, Liu, S. | 登録日 | 2010-10-29 | 公開日 | 2011-11-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | The flavin reductase DSZD from a desulfurizing mycobacterium goodii strain: systemic manipulation and investigation based on the crystal structure To be Published
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3DL4
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![BU of 3dl4 by Molmil](/molmil-images/mine/3dl4) | Non-Aged Form of Mouse Acetylcholinesterase Inhibited by Tabun- Update | 分子名称: | Acetylcholinesterase, HEXAETHYLENE GLYCOL | 著者 | Carletti, E, Li, H, Li, B, Ekstrom, F, Nicolet, Y, Loiodice, M, Gillon, E, Froment, M.T, Lockridge, O, Schopfer, L.M, Masson, P, Nachon, F. | 登録日 | 2008-06-26 | 公開日 | 2008-12-02 | 最終更新日 | 2021-03-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation. J.Am.Chem.Soc., 130, 2008
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4BBQ
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![BU of 4bbq by Molmil](/molmil-images/mine/4bbq) | Crystal structure of the CXXC and PHD domain of Human Lysine-specific Demethylase 2A (KDM2A)(FBXL11) | 分子名称: | 1,2-ETHANEDIOL, LYSINE-SPECIFIC DEMETHYLASE 2A, ZINC ION | 著者 | Allerston, C.K, Watson, A.A, Edlich, C, Li, B, Chen, Y, Ball, L, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Laue, E.D, Gileadi, O. | 登録日 | 2012-09-27 | 公開日 | 2012-10-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Crystal Structure of the Cxxc and Phd Domain of Human Lysine-Specific Demethylase 2A (Kdm2A)(Fbxl11) To be Published
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1CZ8
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![BU of 1cz8 by Molmil](/molmil-images/mine/1cz8) | VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY | 分子名称: | HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ... | 著者 | Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B. | 登録日 | 1999-09-01 | 公開日 | 2000-03-20 | 最終更新日 | 2017-04-05 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J.Mol.Biol., 293, 1999
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6UFR
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![BU of 6ufr by Molmil](/molmil-images/mine/6ufr) | Structure of recombinantly assembled E46K alpha-synuclein fibrils | 分子名称: | Alpha-synuclein | 著者 | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Li, B, Jiang, L. | 登録日 | 2019-09-24 | 公開日 | 2020-02-19 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure. Proc.Natl.Acad.Sci.USA, 117, 2020
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6PES
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![BU of 6pes by Molmil](/molmil-images/mine/6pes) | Cryo-EM structure of alpha-synuclein H50Q Wide Fibril | 分子名称: | Alpha-synuclein | 著者 | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | 登録日 | 2019-06-20 | 公開日 | 2019-11-27 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
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2MUS
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![BU of 2mus by Molmil](/molmil-images/mine/2mus) | HADDOCK calculated model of LIN5001 bound to the HET-s amyloid | 分子名称: | 3''',4'-bis(carboxymethyl)-2,2':5',2'':5'',2''':5''',2''''-quinquethiophene-5,5''''-dicarboxylic acid, Heterokaryon incompatibility protein s | 著者 | Hermann, U.S, Schuetz, A.K, Shirani, H, Saban, D, Nuvolone, M, Huang, D.H, Li, B, Ballmer, B, Aslund, A.K.O, Mason, J.J, Rushing, E, Budka, H, Hammarstrom, P, Bockmann, A, Caflisch, A, Meier, B.H, Nilsson, P.K.R, Hornemann, S, Aguzzi, A. | 登録日 | 2014-09-16 | 公開日 | 2017-02-01 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure-based drug design identifies polythiophenes as antiprion compounds. Sci Transl Med, 7, 2015
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1RWE
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![BU of 1rwe by Molmil](/molmil-images/mine/1rwe) | Enhancing the activity of insulin at receptor edge: crystal structure and photo-cross-linking of A8 analogues | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | 著者 | Wan, Z, Xu, B, Chu, Y.C, Li, B, Nakagawa, S.H, Qu, Y, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A. | 登録日 | 2003-12-16 | 公開日 | 2005-02-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues. Biochemistry, 43, 2004
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1KAT
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![BU of 1kat by Molmil](/molmil-images/mine/1kat) | Solution Structure of a Phage-Derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor | 分子名称: | Phage-Derived Peptide Antagonist, Vascular Endothelial Growth Factor | 著者 | Pan, B, Li, B, Russell, S.J, Tom, J.Y.K, Cochran, A.G, Fairbrother, W.J. | 登録日 | 2001-11-02 | 公開日 | 2002-11-02 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of a Phage-derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor J.Mol.Biol., 316, 2002
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7F59
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![BU of 7f59 by Molmil](/molmil-images/mine/7f59) | DNQX-bound GluK2-1xNeto2 complex | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | 登録日 | 2021-06-21 | 公開日 | 2021-09-29 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F56
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![BU of 7f56 by Molmil](/molmil-images/mine/7f56) | DNQX-bound GluK2-1xNeto2 complex, with asymmetric LBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | 著者 | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | 登録日 | 2021-06-21 | 公開日 | 2021-09-29 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F57
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![BU of 7f57 by Molmil](/molmil-images/mine/7f57) | Kainate-bound GluK2-1xNeto2 complex, at the desensitized state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | 著者 | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | 登録日 | 2021-06-21 | 公開日 | 2021-09-29 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F5B
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![BU of 7f5b by Molmil](/molmil-images/mine/7f5b) | LBD-TMD focused reconstruction of DNQX-bound GluK2-1xNeto2 complex | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | 登録日 | 2021-06-21 | 公開日 | 2021-09-29 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F5A
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![BU of 7f5a by Molmil](/molmil-images/mine/7f5a) | DNQX-bound GluK2-2xNeto2 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | 著者 | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | 登録日 | 2021-06-21 | 公開日 | 2021-09-29 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Kainate receptor modulation by NETO2. Nature, 599, 2021
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6PEO
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![BU of 6peo by Molmil](/molmil-images/mine/6peo) | Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril | 分子名称: | Alpha-synuclein | 著者 | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | 登録日 | 2019-06-20 | 公開日 | 2019-11-27 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
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5HKP
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![BU of 5hkp by Molmil](/molmil-images/mine/5hkp) | Crystal structure of mouse Tankyrase/human TRF1 complex | 分子名称: | Tankyrase-1, Telomeric repeat-binding factor 1 | 著者 | Wang, Z, Li, B, Rao, Z, Xu, W. | 登録日 | 2016-01-14 | 公開日 | 2016-03-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of a tankyrase 1-telomere repeat factor 1 complex. Acta Crystallogr F Struct Biol Commun, 72, 2016
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1DNM
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![BU of 1dnm by Molmil](/molmil-images/mine/1dnm) | CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG) | 分子名称: | DNA (5'-D(*CP*GP*CP*AP*AP*GP*CP*TP*GP*GP*CP*G)-3') | 著者 | Webster, G.D, Sanderson, M.R, Skelly, J.V, Neidle, S, Swann, P.F, Li, B.F, Tickle, I.J. | 登録日 | 1990-06-22 | 公開日 | 1991-07-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG). Proc.Natl.Acad.Sci.USA, 87, 1990
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2C0T
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![BU of 2c0t by Molmil](/molmil-images/mine/2c0t) | Src family kinase Hck with bound inhibitor A-641359 | 分子名称: | CALCIUM ION, N-(4-{4-AMINO-1-[1-(TETRAHYDRO-2H-PYRAN-4-YL)PIPERIDIN-4-YL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE, TYROSINE-PROTEIN KINASE HCK | 著者 | Borhani, D.W, Burchat, A, Calderwood, D.J, Hirst, G.C, Li, B, Loew, A. | 登録日 | 2005-09-07 | 公開日 | 2006-09-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection. Bioorg.Med.Chem.Lett., 16, 2006
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2C0I
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![BU of 2c0i by Molmil](/molmil-images/mine/2c0i) | Src family kinase Hck with bound inhibitor A-420983 | 分子名称: | CALCIUM ION, N-(4-{4-AMINO-1-[4-(4-METHYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE, TYROSINE-PROTEIN KINASE HCK | 著者 | Borhani, D.W, Burchat, A, Calderwood, D.J, Hirst, G.C, Li, B, Loew, A. | 登録日 | 2005-09-03 | 公開日 | 2006-09-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection. Bioorg.Med.Chem.Lett., 16, 2006
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2C0O
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![BU of 2c0o by Molmil](/molmil-images/mine/2c0o) | Src family kinase Hck with bound inhibitor A-770041 | 分子名称: | CALCIUM ION, N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE, TYROSINE-PROTEIN KINASE HCK | 著者 | Borhani, D.W, Burchat, A, Calderwood, D.J, Hirst, G.C, Li, B, Loew, A. | 登録日 | 2005-09-06 | 公開日 | 2006-09-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection. Bioorg.Med.Chem.Lett., 16, 2006
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5I9J
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![BU of 5i9j by Molmil](/molmil-images/mine/5i9j) | Structure of the cholesterol and lutein-binding domain of human STARD3 at 1.74A | 分子名称: | 1,2-ETHANEDIOL, L(+)-TARTARIC ACID, SULFATE ION, ... | 著者 | Horvath, M.P, Bernstein, P.S, Li, B, George, E.W, Tran, Q.T. | 登録日 | 2016-02-20 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Structure of the lutein-binding domain of human StARD3 at 1.74 angstrom resolution and model of a complex with lutein. Acta Crystallogr.,Sect.F, 72, 2016
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5H5P
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![BU of 5h5p by Molmil](/molmil-images/mine/5h5p) | |