2C0I

Src family kinase Hck with bound inhibitor A-420983

Summary for 2C0I

• Entry DOI: 10.2210/pdb2c0i/pdb
• Related: 1AD5 1BU1 1QCF 2C0O 2C0T 2HCK 3HCK 4HCK 5HCK
• Descriptor: TYROSINE-PROTEIN KINASE HCK, N-(4-{4-AMINO-1-[4-(4-METHYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: tyrosine-protein kinase, transferase, atp-binding, kinase, lipoprotein, myristate, nucleotide-binding, palmitate, phosphorylation, sh2 domain, sh3 domain
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 105268.05

Authors

Borhani, D.W.,Burchat, A.,Calderwood, D.J.,Hirst, G.C.,Li, B.,Loew, A. (deposition date: 2005-09-03, release date: 2006-09-20, Last modification date: 2023-12-13)

• Primary citation: Burchat, A.,Borhani, D.W.,Calderwood, D.J.,Hirst, G.C.,Li, B.,Stachlewitz, R.F.; Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection.; Bioorg.Med.Chem.Lett., 16:118-, 2006; PubMed: 16216497; DOI: 10.1016/J.BMCL.2005.09.039

Experimental method

X-RAY DIFFRACTION (2.3 Å)