1QCF

CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR

Summary for 1QCF

Entry DOI	10.2210/pdb1qcf/pdb
Related	1AD5
Descriptor	Tyrosine-protein kinase HCK, 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE (3 entities in total)
Functional Keywords	tyrosine kinase-inhibitor complex, down-regulated kinase, ordered activation loop, tyrosine kinase
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Lysosome. Isoform 2: Cell membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle: P08631
Total number of polymer chains	1
Total formula weight	52281.58
Authors	Schindler, T.,Sicheri, F.,Pico, A.,Gazit, A.,Levitzki, A.,Kuriyan, J. (deposition date: 1999-05-04, release date: 1999-06-08, Last modification date: 2022-12-21)
Primary citation	Schindler, T.,Sicheri, F.,Pico, A.,Gazit, A.,Levitzki, A.,Kuriyan, J. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol.Cell, 3:639-648, 1999 Cited by PubMed: 10360180 DOI: 10.1016/S1097-2765(00)80357-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation