6GCR
Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor
Summary for 6GCR
Entry DOI | 10.2210/pdb6gcr/pdb |
Related | 6GCW 6GCX |
Descriptor | Focal adhesion kinase 1, 2-[[2-[[4-[[[3,4-bis(oxidanylidene)-2-[2-(propanoylamino)ethylamino]cyclobuten-1-yl]amino]methyl]phenyl]amino]-5-chloranyl-pyrimidin-4-yl]amino]-~{N}-methyl-benzamide (3 entities in total) |
Functional Keywords | focal adhesion kinase cell adhesion signalling irreversible inhibitor 2, 4-pyrimidine derivatives, cell adhesion |
Biological source | Gallus gallus (Chicken) |
Total number of polymer chains | 1 |
Total formula weight | 32308.84 |
Authors | Yen-Pon, E.,Li, B.,Acebron-Garcia de Eulate, M.,Tomkiewicz-Raulet, C.,Dawson, J.,Lietha, D.,Frame, M.C.,Coumoul, X.,Garbay, C.,Etheve-Quelquejeu, M.,Chen, H. (deposition date: 2018-04-19, release date: 2019-05-01, Last modification date: 2019-10-02) |
Primary citation | Yen-Pon, E.,Li, B.,Acebron-Garcia-de-Eulate, M.,Tomkiewicz-Raulet, C.,Dawson, J.,Lietha, D.,Frame, M.C.,Coumoul, X.,Garbay, C.,Etheve-Quelquejeu, M.,Chen, H. Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase. Acs Chem.Biol., 13:2067-2073, 2018 Cited by PubMed: 29897729DOI: 10.1021/acschembio.8b00250 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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