4GM8
 
 | | Crystal structure of human WD repeat domain 5 with compound MM-102 | | Descriptor: | MM-102, WD repeat-containing protein 5 | | Authors: | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | | Deposit date: | 2012-08-15 | | Release date: | 2013-07-31 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
|
|
2I46
 | | Crystal structure of human TPP1 | | Descriptor: | Adrenocortical dysplasia protein homolog | | Authors: | Wang, F, Podell, E.R, Zaug, A.J, Yang, Y.T, Baciu, P, Else, T, Hammer, G.D, Cech, T.R, Lei, M. | | Deposit date: | 2006-08-21 | | Release date: | 2006-11-28 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature, 445, 2007
|
|
4DNC
 | | Crystal structure of human MOF in complex with MSL1 | | Descriptor: | Histone acetyltransferase KAT8, Male-specific lethal 1 homolog, ZINC ION | | Authors: | Huang, J, Lei, M. | | Deposit date: | 2012-02-08 | | Release date: | 2012-07-25 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex.
Cell Res., 22, 2012
|
|
4GM9
 | | Crystal structure of human WD repeat domain 5 with compound MM-401 | | Descriptor: | MM-401, WD repeat-containing protein 5 | | Authors: | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Liu, L, Dou, Y, Lei, M, Wang, S. | | Deposit date: | 2012-08-15 | | Release date: | 2014-02-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of human WD repeat domain 5 with compound MM-401
To be Published
|
|
3BU8
 | | Crystal Structure of TRF2 TRFH domain and TIN2 peptide complex | | Descriptor: | TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 2 | | Authors: | Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. | | Deposit date: | 2008-01-02 | | Release date: | 2008-02-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
|
|
4ZMI
 | | Crystal structure of the Helical domain of S. pombe Taz1 | | Descriptor: | COBALT (II) ION, MAGNESIUM ION, Telomere length regulator taz1 | | Authors: | Deng, W, Wu, J, Wang, F, Lei, M. | | Deposit date: | 2015-05-04 | | Release date: | 2015-09-23 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Fission yeast telomere-binding protein Taz1 is a functional but not a structural counterpart of human TRF1 and TRF2.
Cell Res., 25, 2015
|
|
4ZMK
 | |
4GMB
 | | Crystal structure of human WD repeat domain 5 with compound MM-402 | | Descriptor: | MM-402, WD repeat-containing protein 5 | | Authors: | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | | Deposit date: | 2012-08-15 | | Release date: | 2014-02-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.781 Å) | | Cite: | Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J.Med.Chem., 60, 2017
|
|
4I80
 | |
7LH9
 | | Crystal structure of BRPF2 PWWP domain in complex with DNA | | Descriptor: | Bromodomain-containing protein 1, DNA | | Authors: | Zhang, M, Lei, M, Qin, S, Dong, A, Yang, A, Li, Y, Loppnau, P, Hughes, T.R, Arrowsmith, C.H, Edwards, A.M, Min, J, Liu, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2021-01-21 | | Release date: | 2021-02-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
Biochim Biophys Acta Gene Regul Mech, 1864, 2021
|
|
5F6K
 | | Crystal structure of the MLL3-Ash2L-RbBP5 complex | | Descriptor: | Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Li, Y, Lei, M, Chen, Y. | | Deposit date: | 2015-12-06 | | Release date: | 2016-02-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.411 Å) | | Cite: | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
|
|
2SRC
 | | CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP | | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TYROSINE-PROTEIN KINASE SRC | | Authors: | Xu, W, Doshi, A, Lei, M, Eck, M.J, Harrison, S.C. | | Deposit date: | 1998-12-29 | | Release date: | 1999-07-22 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
Mol.Cell, 3, 1999
|
|
2HKO
 | | Crystal structure of LSD1 | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1 | | Authors: | Chen, Y, Yang, Y.T, Wang, F, Yanane, K, Zhang, Y, Lei, M. | | Deposit date: | 2006-07-05 | | Release date: | 2006-08-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
4ZOU
 | |
5DOI
 | | Crystal structure of Tetrahymena p45N and p19 | | Descriptor: | Telomerase associated protein p45, Telomerase-associated protein 19 | | Authors: | Wan, B, Tang, T, Wu, J, Lei, M. | | Deposit date: | 2015-09-11 | | Release date: | 2015-11-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
Nat.Struct.Mol.Biol., 22, 2015
|
|
5DOK
 | | Crystal structure of Tetrahymena p45C | | Descriptor: | MAGNESIUM ION, Telomerase associated protein p45 | | Authors: | Wan, B, Tang, T, Wu, J, Lei, M. | | Deposit date: | 2015-09-11 | | Release date: | 2015-11-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
Nat.Struct.Mol.Biol., 22, 2015
|
|
5DOF
 | | Crystal structure of Tetrahymena p19 | | Descriptor: | Telomerase-associated protein 19 | | Authors: | Wan, B, Tang, T, Wu, J, Lei, M. | | Deposit date: | 2015-09-11 | | Release date: | 2015-11-25 | | Last modified: | 2015-12-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.
Nat.Struct.Mol.Biol., 22, 2015
|
|
3L82
 | | X-ray Crystal structure of TRF1 and Fbx4 complex | | Descriptor: | F-box only protein 4, Telomeric repeat-binding factor 1 | | Authors: | Zeng, Z.X, Wang, W, Yang, Y.T, Chen, Y, Yang, X.M, Diehl, J.A, Liu, X.D, Lei, M. | | Deposit date: | 2009-12-29 | | Release date: | 2010-03-09 | | Last modified: | 2013-09-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4)
Dev.Cell, 18, 2010
|
|
5F6L
 | | The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L | | Descriptor: | Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Li, Y, Lei, M, Chen, Y. | | Deposit date: | 2015-12-06 | | Release date: | 2016-02-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
|
|
5F5E
 | |
5F59
 | | The crystal structure of MLL3 SET domain | | Descriptor: | Histone-lysine N-methyltransferase 2C, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | | Authors: | Li, Y, Lei, M, Chen, Y. | | Deposit date: | 2015-12-04 | | Release date: | 2016-02-24 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.801 Å) | | Cite: | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
|
|
4O26
 | |
3NBH
 | | Crystal structure of human RMI1C-RMI2 complex | | Descriptor: | RecQ-mediated genome instability protein 1, RecQ-mediated genome instability protein 2 | | Authors: | Wang, F, Yang, Y, Singh, T.R, Busygina, V, Guo, R, Wan, K, Wang, W, Sung, P, Meetei, A.R, Lei, M. | | Deposit date: | 2010-06-03 | | Release date: | 2010-09-22 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of RMI1 and RMI2, Two OB-Fold Regulatory Subunits of the BLM Complex.
Structure, 18, 2010
|
|
6MLC
 | | PHD6 domain of MLL3 in complex with histone H4 | | Descriptor: | GLYCEROL, Histone H4, Histone-lysine N-methyltransferase 2C, ... | | Authors: | Dong, A, Liu, Y, Qin, S, Lei, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2018-09-27 | | Release date: | 2018-10-24 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019
|
|
3OIQ
 | | Crystal structure of yeast telomere protein Cdc13 OB1 and the catalytic subunit of DNA polymerase alpha Pol1 | | Descriptor: | Cell division control protein 13, DNA polymerase alpha catalytic subunit A | | Authors: | Sun, J, Yang, Y, Wan, K, Mao, N, Yu, T.Y, Lin, Y.C, DeZwaan, D.C, Freeman, B.C, Lin, J.J, Lue, N.F, Lei, M. | | Deposit date: | 2010-08-19 | | Release date: | 2010-11-03 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase alpha.
Cell Res., 21, 2011
|
|
