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PDB: 152 件
5K28
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BU of 5k28 by Molmil
Structure of the unbound SH3 domain of MLK3
分子名称: Mitogen-activated protein kinase kinase kinase 11
著者Kall, S.K, Lavie, A.
登録日2016-05-18
公開日2017-12-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3.
J. Biol. Chem., 293, 2018
5K26
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Structure of the SH3 domain of MLK3 bound to peptide generated from phage display
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mitogen-activated protein kinase kinase kinase 11,Chimera protein of MLK3-SH3 and MIP
著者Kall, S.K, Lavie, A.
登録日2016-05-18
公開日2017-12-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3.
J. Biol. Chem., 293, 2018
1XYM
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BU of 1xym by Molmil
THE ROLE OF THE DIVALENT METAL ION IN SUGAR BINDING, RING OPENING, AND ISOMERIZATION BY D-XYLOSE ISOMERASE: REPLACEMENT OF A CATALYTIC METAL BY AN AMINO-ACID
分子名称: D-glucose, HYDROXIDE ION, MAGNESIUM ION, ...
著者Allen, K.N, Lavie, A, Petsko, G.A, Ringe, D.
登録日1993-12-07
公開日1994-05-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid.
Biochemistry, 33, 1994
1XYL
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BU of 1xyl by Molmil
THE ROLE OF THE DIVALENT METAL ION IN SUGAR BINDING, RING OPENING, AND ISOMERIZATION BY D-XYLOSE ISOMERASE: REPLACEMENT OF A CATALYTIC METAL BY AN AMINO-ACID
分子名称: HYDROXIDE ION, MAGNESIUM ION, XYLOSE ISOMERASE
著者Allen, K.N, Lavie, A, Petsko, G.A, Ringe, D.
登録日1993-12-07
公開日1994-05-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid.
Biochemistry, 33, 1994
4ECD
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BU of 4ecd by Molmil
2.5 Angstrom Resolution Crystal Structure of Bifidobacterium longum Chorismate Synthase
分子名称: CHLORIDE ION, Chorismate synthase
著者Light, S.H, Minasov, G, Krishna, S.N, Shuvalova, L, Kwon, K, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2012-03-26
公開日2012-04-04
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献2.5 Angstrom Resolution Crystal Structure of Bifidobacterium longum Chorismate Synthase
TO BE PUBLISHED
4GFS
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BU of 4gfs by Molmil
1.8 Angstrom Crystal Structure of the 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium LT2 with Nickel Bound at Active Site
分子名称: 3-dehydroquinate dehydratase, NICKEL (II) ION, SUCCINIC ACID
著者Light, S.H, Minasov, G, Krishna, S.N, Shuvalova, L, Kwon, K, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2012-08-03
公開日2012-08-15
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献1.8 Angstrom Crystal Structure of the 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium LT2 with Nickel Bound at Active Site
TO BE PUBLISHED
6C4S
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BU of 6c4s by Molmil
Human cSrc SH3 Domain in complex with Choline Kinase fragment 60-69
分子名称: Proto-oncogene tyrosine-protein kinase Src,cSrc SH3 Domain, ZINC ION
著者Kall, S.L, Lavie, A.
登録日2018-01-12
公開日2019-01-23
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase.
Sci Rep, 9, 2019
1LVG
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BU of 1lvg by Molmil
Crystal structure of mouse guanylate kinase in complex with GMP and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, Guanylate kinase, ...
著者Sekulic, N, Shuvalova, L, Spangenberg, O, Konrad, M, Lavie, A.
登録日2002-05-28
公開日2002-12-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural characterization of the closed conformation of mouse guanylate kinase.
J.Biol.Chem., 277, 2002
1KGD
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BU of 1kgd by Molmil
Crystal Structure of the Guanylate Kinase-like Domain of Human CASK
分子名称: FORMIC ACID, PERIPHERAL PLASMA MEMBRANE CASK
著者Li, Y, Spangenberg, O, Paarmann, I, Konrad, M, Lavie, A.
登録日2001-11-26
公開日2001-12-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.314 Å)
主引用文献Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains.
J.Biol.Chem., 277, 2002
1NN0
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BU of 1nn0 by Molmil
Crystal structure of human thymidylate kinase with ddTMP and ADP
分子名称: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
登録日2003-01-12
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN5
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BU of 1nn5 by Molmil
Crystal structure of human thymidylate kinase with d4TMP + AppNHp
分子名称: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
登録日2003-01-12
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
6CQ7
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BU of 6cq7 by Molmil
The SH3 domain of MLK3 in complex with poly-proline peptide derived from Htt
分子名称: Mitogen-activated protein kinase kinase kinase 11, Huntingtin fusion protein
著者Kall, S.L, Lavie, A.
登録日2018-03-14
公開日2018-09-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The SH3 domain of MLK3 in complex with poly-proline peptide derived from Htt
To Be Published
5DNE
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BU of 5dne by Molmil
Crystal structure of the Asn-bound guinea pig L-asparaginase 1 catalytic domain active site mutant K188M
分子名称: 1,2-ETHANEDIOL, ASPARAGINE, L-asparaginase
著者Schalk, A.M, Lavie, A.
登録日2015-09-10
公開日2016-01-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Experimental Data in Support of a Direct Displacement Mechanism for Type I/II l-Asparaginases.
J.Biol.Chem., 291, 2016
2A2Z
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BU of 2a2z by Molmil
Crystal Structure of human deoxycytidine kinase in complex with deoxycytidine and uridine diphosphate
分子名称: 2'-DEOXYCYTIDINE, CALCIUM ION, Deoxycytidine kinase, ...
著者Godsey, M.H, Ort, S, Sabini, E, Konrad, M, Lavie, A.
登録日2005-06-23
公開日2006-01-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.
Biochemistry, 45, 2006
5DNC
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BU of 5dnc by Molmil
Crystal structure of the Asn-bound guinea pig L-asparaginase 1 catalytic domain active site mutant T19A
分子名称: 1,2-ETHANEDIOL, ASPARAGINE, L-asparaginase
著者Schalk, A.M, Lavie, A.
登録日2015-09-09
公開日2016-01-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Experimental Data in Support of a Direct Displacement Mechanism for Type I/II l-Asparaginases.
J.Biol.Chem., 291, 2016
1E9E
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BU of 1e9e by Molmil
Mutant human thymidylate kinase (F105Y) complexed with dTMP and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
著者Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
登録日2000-10-11
公開日2001-10-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9F
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BU of 1e9f by Molmil
Mutant human thymidylate kinase complexed with TMP and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
著者Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reinstein, J, Goody, R.S, Konrad, M, Schlichting, I.
登録日2000-10-11
公開日2001-10-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9C
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BU of 1e9c by Molmil
Mutant human thymidylate kinase complexed with TMP and APPNP
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
登録日2000-10-10
公開日2001-10-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9B
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BU of 1e9b by Molmil
Human thymidylate kinase complexed with AZTMP and APPNP
分子名称: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
登録日2000-10-10
公開日2001-10-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E98
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Wild type human thymidylate kinase complexed with AZTMP and ADP
分子名称: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
登録日2000-10-10
公開日2001-10-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
2A30
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BU of 2a30 by Molmil
Crystal structure of human deoxycytidine kinase in complex with deoxycytidine
分子名称: 2'-DEOXYCYTIDINE, CALCIUM ION, Deoxycytidine kinase
著者Godsey, M.H, Ort, S, Sabini, E, Konrad, M, Lavie, A.
登録日2005-06-23
公開日2006-01-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.
Biochemistry, 45, 2006
5DND
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BU of 5dnd by Molmil
Crystal structure of the Asn-bound guinea pig L-asparaginase 1 catalytic domain active site mutant T116A
分子名称: 1,2-ETHANEDIOL, ASPARAGINE, L-asparaginase
著者Schalk, A.M, Lavie, A.
登録日2015-09-09
公開日2016-01-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Experimental Data in Support of a Direct Displacement Mechanism for Type I/II l-Asparaginases.
J.Biol.Chem., 291, 2016
1E9A
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BU of 1e9a by Molmil
Human thymidylate kinase complexed with the bisubstrate inhibitor AZTP5A
分子名称: MAGNESIUM ION, P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE, THYMIDYLATE KINASE
著者Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
登録日2000-10-10
公開日2001-10-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9D
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BU of 1e9d by Molmil
Mutant human thymidylate kinase (F105Y) complexed with AZTMP and ADP
分子名称: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
登録日2000-10-10
公開日2001-10-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E99
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Human thymidylate kinase complexed with AZTMP and ADP
分子名称: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reinstein, J, Goody, R.S, Konrad, M, Schlichting, I.
登録日2000-10-10
公開日2001-10-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000

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