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PDB: 193 results

3Q0W
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ETHR From mycobacterium tuberculosis in complex with compound BDM33066
Descriptor: (2S)-2-amino-3-methyl-1-{4-[3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one, GLYCEROL, HTH-type transcriptional regulator EthR
Authors:Flipo, M, Desrose, M, Dirie, B, Carette, X, Leroux, F, Lens, Z, Rucktooa, P, Piveteau, C, Demirkaya, F, Locht, C, Villeret, V, Christophe, T, Jeon, H.K, Brodin, P, Deprez, B, Baulard, A, Willand, N.
Deposit date:2010-12-16
Release date:2011-12-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands.
Nucleic Acids Res., 40, 2012
3RE4
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Crystal Structure of Archaeoglobus Fulgidus Rio1 Kinase bound to Toyocamycin.
Descriptor: 4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, RIO-type serine/threonine-protein kinase Rio1
Authors:Kiburu, I.N, LaRonde-LeBlanc, N.
Deposit date:2011-04-02
Release date:2012-05-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Interaction of rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activity.
Plos One, 7, 2012
1Z0Q
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Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42)
Descriptor: Alzheimer's disease amyloid
Authors:Tomaselli, S, Esposito, V, Vangone, P, van Nuland, N.A, Bonvin, A.M, Guerrini, R, Tancredi, T, Temussi, P.A, Picone, D.
Deposit date:2005-03-02
Release date:2006-05-23
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:The alpha-to-beta Conformational Transition of Alzheimer's Abeta-(1-42) Peptide in Aqueous Media is Reversible: A Step by Step Conformational Analysis Suggests the Location of beta Conformation Seeding
Chembiochem, 7, 2006
3TP0
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Structural activation of the transcriptional repressor EthR from M. tuberculosis by single amino-acid change mimicking natural and synthetic ligands
Descriptor: 3-oxo-3-{4-[3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}propanenitrile, HTH-type transcriptional regulator EthR
Authors:Carette, X, Blondiaux, N, Willery, E, Hoos, S, Lecat-Guillet, N, Lens, Z, Wohlkonig, A, Wintjens, R, Soror, S, Fr nois, F, Diri, B, Villeret, V, England, P, Lippens, G, Deprez, B, Locht, C, Willand, N, Baulard, A.
Deposit date:2011-09-07
Release date:2011-12-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands.
Nucleic Acids Res., 40, 2011
2BS5
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LECTIN FROM RALSTONIA SOLANACEARUM COMPLEXED WITH 2-FUCOSYLLACTOSE
Descriptor: CHLORIDE ION, FUCOSE-BINDING LECTIN PROTEIN, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:Mitchell, E.P, Kostlanova, N, Wimmerova, M, Imberty, A.
Deposit date:2005-05-18
Release date:2005-05-19
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Fucose-Binding Lectin from Ralstonia Solanacearum: A New Type of {Beta}-Propeller Architecture Formed by Oligomerization and Interacting with Fucoside, Fucosyllactose, and Plant Xyloglucan.
J.Biol.Chem., 280, 2005
3Q0U
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EthR from Mycobacterium tuberculosis in complex with compound BDM31379
Descriptor: 2-phenyl-1-{4-[3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}ethanone, HTH-type transcriptional regulator EthR
Authors:Flipo, M, Desroses, M, Dirie, B, Carette, X, Lens, Z, Rucktooa, P, Leroux, F, Piveteau, C, Demirkaya, F, Locht, C, Villeret, V, Christophe, T, Jeon, H.K, Brodin, P, Deprez, B, Baulard, A, Willand, N.
Deposit date:2010-12-16
Release date:2012-01-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design, synthesis and optimization of new EthR inhibitors. A new alternative approach to fight tuberculosis by boosting ethionamide
To be Published
1ZOR
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Isocitrate dehydrogenase from the hyperthermophile Thermotoga maritima
Descriptor: SODIUM ION, isocitrate dehydrogenase
Authors:Karlstrom, M, Steen, I.H, Birkeland, N.-K, Ladenstein, R.
Deposit date:2005-05-13
Release date:2006-05-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:The crystal structure of a hyperthermostable subfamily II isocitrate dehydrogenase from Thermotoga maritima.
Febs J., 273, 2006
3Q3S
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EthR from Mycobacterium tuberculosis in complex with compound BDM5683
Descriptor: 2-(2-methylphenoxy)-N-[2-(4-methylphenyl)-2H-benzotriazol-5-yl]acetamide, HTH-type transcriptional regulator EthR
Authors:Lens, Z, Willand, N, Villeret, V.
Deposit date:2010-12-22
Release date:2012-01-18
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:EthR from Mycobacterium tuberculosis in complex with compound BDM5683
To be Published
2BT9
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Lectin from Ralstonia solanacearum complexed with Me-fucoside
Descriptor: LECTIN, methyl alpha-L-fucopyranoside
Authors:Mitchell, E.P, Kostlanova, N, Wimmerova, M, Imberty, A.
Deposit date:2005-05-27
Release date:2005-06-02
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (0.94 Å)
Cite:The fucose-binding lectin from Ralstonia solanacearum. A new type of beta-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan.
J. Biol. Chem., 280, 2005
2BS6
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LECTIN FROM RALSTONIA SOLANACEARUM COMPLEXED WITH XYLOGLUCAN FRAGMENT
Descriptor: GLYCEROL, LECTIN, alpha-L-fucopyranose, ...
Authors:Mitchell, E.P, Kostlanova, N, Wimmerova, M, Imberty, A.
Deposit date:2005-05-18
Release date:2005-05-19
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The fucose-binding lectin from Ralstonia solanacearum. A new type of beta-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan.
J. Biol. Chem., 280, 2005
4PKN
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Crystal structure of the football-shaped GroEL-GroES2-(ADPBeFx)14 complex containing substrate Rubisco
Descriptor: 10 kDa chaperonin, 60 kDa chaperonin, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Fei, X, Ye, X, Laronde-Leblanc, N, Lorimer, G.H.
Deposit date:2014-05-15
Release date:2014-08-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.66 Å)
Cite:Formation and structures of GroEL:GroES2 chaperonin footballs, the protein-folding functional form.
Proc.Natl.Acad.Sci.USA, 111, 2014
4PKO
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Crystal structure of the Football-shaped GroEL-GroES2-(ADPBeFx)14 complex
Descriptor: 10 kDa chaperonin, 60 kDa chaperonin, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Fei, X, Ye, X, Laronde-Leblanc, N, Lorimer, G.H.
Deposit date:2014-05-15
Release date:2014-08-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.84 Å)
Cite:Formation and structures of GroEL:GroES2 chaperonin footballs, the protein-folding functional form.
Proc.Natl.Acad.Sci.USA, 111, 2014
4GYG
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Crystal structure of the Rio2 kinase from Chaetomium thermophilum
Descriptor: Rio2 kinase
Authors:Ferreira-Cerca, S, Sagar, V, Schafer, T, Diop, M, Wesseling, A.M, Lu, H, Chai, E, Hurt, E, LaRonde-LeBlanc, N.
Deposit date:2012-09-05
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.482 Å)
Cite:ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit.
Nat.Struct.Mol.Biol., 19, 2012
7KTX
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BU of 7ktx by Molmil
Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to a Fab in DDM detergent
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ...
Authors:Miller-Vedam, L.E, Schirle Oakdale, N.S, Braeuning, B, Boydston, E.A, Sevillano, N, Popova, K.D, Bonnar, J.L, Shurtleff, M.J, Prabu, J.R, Stroud, R.M, Craik, C.S, Schulman, B.A, Weissman, J.S, Frost, A.
Deposit date:2020-11-24
Release date:2020-12-02
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.
Elife, 9, 2020
7KRA
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Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to Fab-DH4 in lipid nanodiscs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ...
Authors:Miller-Vedam, L.E, Schirle Oakdale, N.S, Braeuning, B, Boydston, E.A, Sevillano, N, Popova, K.D, Bonnar, J.L, Shurtleff, M.J, Prabu, J.R, Stroud, R.M, Craik, C.S, Schulman, B.A, Weissman, J.S, Frost, A.
Deposit date:2020-11-19
Release date:2020-12-02
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.
Elife, 9, 2020
2X0J
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2.8 A RESOLUTION STRUCTURE OF MALATE DEHYDROGENASE FROM ARCHAEOGLOBUS FULGIDUS IN COMPLEX WITH ETHENO-NAD
Descriptor: ETHENO-NAD, MALATE DEHYDROGENASE, SULFATE ION
Authors:Irimia, A, Madern, D, Zaccai, G, Vellieux, F.M, Karshikoff, A, Tibbelin, G, Ladenstein, R, Lien, T, Birkeland, N.K.
Deposit date:2009-12-14
Release date:2009-12-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.786 Å)
Cite:The 2.9A Resolution Crystal Structure of Malate Dehydrogenase from Archaeoglobus Fulgidus: Mechanisms of Oligomerisation and Thermal Stabilisation.
J.Mol.Biol., 335, 2004
4DVZ
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Crystal structure of the Helicobacter pylori CagA oncoprotein
Descriptor: Cytotoxicity-associated immunodominant antigen
Authors:Hayashi, T, Senda, M, Morohashi, H, Higashi, H, Horio, M, Kashiba, Y, Nagase, L, Sasaya, D, Shimizu, T, Venugopalan, N, Kumeta, H, Noda, N, Inagaki, F, Senda, T, Hatakeyama, M.
Deposit date:2012-02-23
Release date:2012-07-25
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA
Cell Host Microbe, 12, 2012
3SDG
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Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.
Descriptor: 4,4,4-trifluoro-1-{4-[3-(1,3-thiazol-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one, HTH-type transcriptional regulator EthR
Authors:Flipo, M, Desroses, M, Lecat-Guillet, N, Villemagne, B, Blondiaux, N, Leroux, F, Piveteau, C, Mathys, V, Flament, M.P, Siepmann, J, Villeret, V, Wohlkonig, A, Wintjens, R, Soror, S.H, Christophe, T, Jeon, H.K, Locht, C, Brodin, P, D prez, B, Baulard, A.R, Willand, N.
Deposit date:2011-06-09
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.
J.Med.Chem., 55, 2012
4D4U
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Crystal Structure of Fucose binding lectin from Aspergillus Fumigatus (AFL) in complex with LewisY tetrasaccharide.
Descriptor: FUCOSE-SPECIFIC LECTIN FLEA, GLYCEROL, alpha-L-fucopyranose, ...
Authors:Houser, J, Komarek, J, Kostlanova, N, Lahmann, M, Cioci, G, Varrot, A, Imberty, A, Wimmerova, M.
Deposit date:2014-10-31
Release date:2015-03-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Insights Into Aspergillus Fumigatus Lectin Specificity: Afl Binding Sites are Functionally Non-Equivalent.
Acta Crystallogr.,Sect.D, 71, 2015
4DVY
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Crystal structure of the Helicobacter pylori CagA oncoprotein
Descriptor: Cytotoxicity-associated immunodominant antigen
Authors:Hayashi, T, Senda, M, Morohashi, H, Higashi, H, Horio, M, Kashiba, Y, Nagase, L, Sasaya, D, Shimizu, T, Venugopalan, N, Kumeta, H, Noda, N, Inagaki, F, Senda, T, Hatakeyama, M.
Deposit date:2012-02-23
Release date:2012-07-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA
Cell Host Microbe, 12, 2012
3SFI
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Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.
Descriptor: 5,5,5-trifluoro-1-{4-[3-(1,3-thiazol-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}pentan-1-one, Transcriptional regulatory repressor protein (TETR-family)
Authors:Flipo, M, Desroses, M, Lecat-Guillet, N, Villemagne, B, Blondiaux, N, Leroux, F, Piveteau, C, Mathys, V, Flament, M.P, Siepmann, J, Villeret, V, Wohlkonig, A, Wintjens, R, Soror, S.H, Christophe, T, Jeon, H.K, Locht, C, Brodin, P, D prez, B, Baulard, A.R, Willand, N.
Deposit date:2011-06-13
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.
J.Med.Chem., 55, 2012
4DW6
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Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis.
Descriptor: AMMONIUM ION, GLYCEROL, HTH-type transcriptional regulator EthR, ...
Authors:Flipo, M, Willand, N, Lecat-Guillet, N, Hounsou, C, Desroses, M, Leroux, F, Lens, Z, Villeret, V, Wohlkonig, A, Wintjens, R, Christophe, T, Jeon, H.K, Locht, C, Brodin, P, Baulard, A.R, Deprez, B.
Deposit date:2012-02-24
Release date:2013-03-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.
J.Med.Chem., 55, 2012
2X0I
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2.9 A RESOLUTION STRUCTURE OF MALATE DEHYDROGENASE FROM ARCHAEOGLOBUS FULGIDUS IN COMPLEX WITH NADH
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MALATE DEHYDROGENASE, SODIUM ION, ...
Authors:Irimia, A, Madern, D, Zaccai, G, Vellieux, F.M.D, Karshikoff, A, Tibbelin, G, Ladenstein, R, Lien, T, Birkeland, N.-K.
Deposit date:2009-12-14
Release date:2009-12-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:The 2.9A Resolution Crystal Structure of Malate Dehydrogenase from Archaeoglobus Fulgidus: Mechanisms of Oligomerisation and Thermal Stabilisation.
J.Mol.Biol., 335, 2004
1PUF
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BU of 1puf by Molmil
Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA
Descriptor: 5'-D(*AP*CP*TP*CP*TP*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*AP*CP*GP*CP*T)-3', 5'-D(*TP*AP*GP*CP*GP*TP*CP*GP*TP*AP*AP*AP*TP*CP*AP*TP*AP*GP*AP*G)-3', Homeobox protein Hox-A9, ...
Authors:Laronde-Leblanc, N.A, Wolberger, C.
Deposit date:2003-06-24
Release date:2003-09-02
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:STRUCTURE OF HOXA9 AND PBX1 BOUND TO DNA: HOX HEXAPEPTIDE AND DNA RECOGNITION ANTERIOR TO POSTERIOR
Genes Dev., 17, 2003
2XE4
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Structure of Oligopeptidase B from Leishmania major
Descriptor: ANTIPAIN, CHLORIDE ION, GLYCEROL, ...
Authors:McLuskey, K, Paterson, N.G, Bland, N.D, Mottram, J.C, Isaacs, N.W.
Deposit date:2010-05-11
Release date:2010-10-06
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of Leishmania Major Oligopeptidase B Gives Insight Into the Enzymatic Properties of a Trypanosomatid Virulence Factor.
J.Biol.Chem., 285, 2010

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数据于2024-06-19公开中

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