3Q0U

EthR from Mycobacterium tuberculosis in complex with compound BDM31379

Summary for 3Q0U

• Entry DOI: 10.2210/pdb3q0u/pdb
• Related: 1U9N 3G1L 3G1M 3G1O 3O8G 3O8L 3Q0V 3Q0W
• Descriptor: HTH-type transcriptional regulator EthR, 2-phenyl-1-{4-[3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}ethanone (3 entities in total)
• Functional Keywords: tetr family, transcriptional repressor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 26306.51

Authors

Flipo, M.,Desroses, M.,Dirie, B.,Carette, X.,Lens, Z.,Rucktooa, P.,Leroux, F.,Piveteau, C.,Demirkaya, F.,Locht, C.,Villeret, V.,Christophe, T.,Jeon, H.K.,Brodin, P.,Deprez, B.,Baulard, A.,Willand, N. (deposition date: 2010-12-16, release date: 2012-01-11, Last modification date: 2024-02-21)

• Primary citation: Flipo, M.,Desroses, M.,Dirie, B.,Carette, X.,Lens, Z.,Rucktooa, P.,Leroux, F.,Piveteau, C.,Demirkaya, F.,Locht, C.,Villeret, V.,Christophe, T.,Jeon, H.K.,Brodin, P.,Deprez, B.,Baulard, A.,Willand, N.; Design, synthesis and optimization of new EthR inhibitors. A new alternative approach to fight tuberculosis by boosting ethionamide; To be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)