3Q0W

ETHR From mycobacterium tuberculosis in complex with compound BDM33066

Summary for 3Q0W

• Entry DOI: 10.2210/pdb3q0w/pdb
• Related: 1U9N 3G1L 3G1M 3G1O 3O8G 3O8L 3Q0U 3Q0V
• Descriptor: HTH-type transcriptional regulator EthR, (2S)-2-amino-3-methyl-1-{4-[3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}butan-1-one, GLYCEROL, ... (4 entities in total)
• Functional Keywords: tetr family, transcriptional repressor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 26379.61

Authors

Flipo, M.,Desrose, M.,Dirie, B.,Carette, X.,Leroux, F.,Lens, Z.,Rucktooa, P.,Piveteau, C.,Demirkaya, F.,Locht, C.,Villeret, V.,Christophe, T.,Jeon, H.K.,Brodin, P.,Deprez, B.,Baulard, A.,Willand, N. (deposition date: 2010-12-16, release date: 2011-12-21, Last modification date: 2024-02-21)

• Primary citation: Carette, X.,Blondiaux, N.,Willery, E.,Hoos, S.,Lecat-Guillet, N.,Lens, Z.,Wohlkonig, A.,Wintjens, R.,Soror, S.H.,Frenois, F.,Dirie, B.,Villeret, V.,England, P.,Lippens, G.,Deprez, B.,Locht, C.,Willand, N.,Baulard, A.R.; Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands.; Nucleic Acids Res., 40:3018-3030, 2012; PubMed: 22156370; DOI: 10.1093/nar/gkr1113

Experimental method

X-RAY DIFFRACTION (1.6 Å)