3O8G

EthR from Mycobacterium tuberculosis in complex with compound BDM14801

Summary for 3O8G

Entry DOI	10.2210/pdb3o8g/pdb
Related	1U9N 3O8H
Descriptor	TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHR, 1-(azidoacetyl)-4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)piperidine (3 entities in total)
Functional Keywords	tetr-family, transcritptional regulatory repressor, inhibitor, dna, dna binding protein, transcription repressor-inhibitor complex, transcription repressor/inhibitor
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	26271.43
Authors	Willand, N.,Desroses, M.,Toto, P.,Diri, B.,Lens, Z.,Villeret, V.,Rucktooa, P.,Locht, C.,Baulard, A.,Deprez, B. (deposition date: 2010-08-03, release date: 2010-09-01, Last modification date: 2024-02-21)
Primary citation	Willand, N.,Desroses, M.,Toto, P.,Dirie, B.,Lens, Z.,Villeret, V.,Rucktooa, P.,Locht, C.,Baulard, A.,Deprez, B. Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator. Acs Chem.Biol., 5:1007-1013, 2010 Cited by PubMed: 20704273 DOI: 10.1021/cb100177g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation