3O8H

EthR from Mycobacterium tuberculosis in complex with compound BDM14950

Summary for 3O8H

Entry DOI	10.2210/pdb3o8h/pdb
Related	1U9N 3O8G
Descriptor	Transcriptional Regulatory Repressor protein (TETR-Family) EthR, 4-iodo-N-[(1-{2-oxo-2-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]ethyl}-1H-1,2,3-triazol-4-yl)methyl]benzenesulfonamide (3 entities in total)
Functional Keywords	tetr-family, transcriptional regulatory repressor, dna, transcription
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	26592.57
Authors	Willand, N.,Desroses, M.,Toto, P.,Diri, B.,Lens, Z.,Villeret, V.,Rucktooa, P.,Locht, C.,Baulard, A.,Deprez, B. (deposition date: 2010-08-03, release date: 2010-09-01, Last modification date: 2024-02-21)
Primary citation	Willand, N.,Desroses, M.,Toto, P.,Dirie, B.,Lens, Z.,Villeret, V.,Rucktooa, P.,Locht, C.,Baulard, A.,Deprez, B. Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator. Acs Chem.Biol., 5:1007-1013, 2010 Cited by PubMed: 20704273 DOI: 10.1021/cb100177g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation